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Review Article
New therapies for chronic hepatitis B
Maya Bitton Alaluf1 andAmir Shlomai1,2,3,*
DOI: 10.1111/liv.13086
This article is protected by copyright. All rights reserved.
Issue
Cover image for Vol. 36 Issue 2
Liver International
1 Department of Medicine D, Beilinson hospital Rabin Medical Center
2 The Liver Institute, Beilinson hospital Rabin Medical Center
3 The Sackler Faculty of Medicine, Tel-Aviv University
* Corresponding author:
Amir Shlomai MD,PhD
Department of Medicine D
Beilinson hospital, Rabin Medical Center
Petah-Tikva, Israel
Tel: +972-3-9376751/3
Fax: +972-9220671
Email: [email protected]
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/liv.13086
Keywords:
Episomal DNA;Viral eradication;Integrative therapy
Abstract
Approximately 350 million people worldwide are chronically infected with hepatitis B virus (HBV), representing a significant public health challenge. Nucleos/tide analogues (NUCs) and interferon alpha (IFNα), the current standard of care for chronic infection, aim at preventing progression of the disease to cirrhosis, hepatocellular carcinoma (HCC) and death. However, in contrast to the case of hepatitis C virus infection, in which novel antiviral drugs cure the vast majority of treated patients, in regards to HBV, cure is rare due to the unusual persistence of viral DNA in the form of covalently closed circular DNA (cccDNA) within the nucleus of infected cells. Available therapies for HBV require lifelong treatment and surveillance, as reactivation frequently occurs following medication cessation and the occurrence of HCC is decreased but not eliminated, even after years of successful viral suppression. Progress has been made in the development of new therapeutics, and it is likely that only a combination of immune modulators, inhibitors of gene expression and replication and cccDNA-targeting drugs will eradicate chronic infection. This review aims to summarize the state of the art in HBV drug research highlighting those agents with the greatest potential for success based on in vitro as well as on data from clinical studies.
This article is protected by copyright. All rights reserved.
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发表于 2016-2-12 21:30
