共存HBsAg和抗-HBs携带者流行病学特征

StephenW

Epidemiological characteristics of the carriers with coexistence of HBsAg and anti-HBs based on a community cohort study

    Z. Pu1, D. Li1, A. Wang1, H. Su1, Z. Shao1, J. Zhang1, Z. Ji1, J. Gao1, B. C. K. Choi2,3 andY. Yan1,*

Article first published online: 14 DEC 2015

DOI: 10.1111/jvh.12492

© 2015 John Wiley & Sons Ltd

Issue
Cover image for Vol. 23 Issue 1
Journal of Viral Hepatitis

Early View (Online Version of Record published before inclusion in an issue)


    1    Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an, Shaanxi, China
    2    Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
    3    Shantou University Medical College, Shantou, China

* Correspondence: Yongping Yan, MD, PhD, Department of Epidemiology, School of Public Heath, The Fourth Military Medical University, No. 169, Changle West Road, Xi'an, Shaanxi 710032, China.
E-mail: [email protected]

Keywords:

    adaptive evolution;coexistence of HBsAg and anti-HBs;HBV S gene;mutation

Summary

The coexistence of HBsAg and anti-HBs is an atypical serological pattern in HBV infection. There is no epidemiological characteristics of this serological pattern in the community and there is controversy over the molecular mechanisms underlying this pattern. We investigated the epidemiological characteristics of the carriers with HBsAg and anti-HBs in a longitudinal community cohort study. The prevalence of this atypical serological pattern was 2.93% (122/4169) in HBsAg-positive populations. The prevalence progressively increased with age from 40 to 70 years old. The rate of HBeAg positive and detectable HBV DNA were both significantly higher in carriers with this pattern than in carriers who were HBsAg positive but anti-HBs negative (26/122 verse 598/4047, P = 0.046; 86/122 verse 275/529,P < 0.001). After 1 year of follow-up, 85.19% of the carriers still had coexistence HBsAg and anti-HBs, 14.81% of the carriers lost their anti-HBs. Viral sequencing showed that carriers with coexistence of HBsAg and anti-HBs had higher numbers of residue changes within the S gene than carriers who were HBsAg positive but anti-HBs negative (2.42 verse 1.33 changes per 100 residues, P < 0.05). Hence, the coexistence of HBsAg and anti-HBs is a unique serological pattern which may be associated with an increased risk of adverse clinical outcome and may be related to HBsAg immune variants which have genotypic heterogeneity.

StephenW

运营商与HBsAg和抗-HBs基于社区队列研究共存流行病学特征

    Z.璞，D为Li，A Wang1，H SU1，Z. Shao1，J. Zhang1，Z. JI1，J. Gao1，BCK Choi2,3安迪。燕1，*

文章首次在线发表：二零一五年十二月十四日

DOI：10.1111 / jvh.12492

©2015年约翰·威利父子有限公司

问题
封面图片卷。 23第1期
杂志病毒性肝炎

早期的浏览（包含之前录制的网上版本发表在一期）


    流行病学1系，公共卫生，第四军医大学，西安，陕西，中国的学校
    公共卫生，多伦多，多伦多大学，ON，加拿大2达拉拉娜学校
    3汕头大学医学院，汕头，中国

*通讯：闫永平博士，流行病学教研室，公共荒地，第四军医大学，第169号，长乐西路，陕西省西安市710032，中国的学校。
电子信箱：[email protected]

关键词：

    适应性进化; HBsAg和抗-HBs共存; HBV S基因突变

概要

HBsAg和抗-HBs的共存是HBV感染非典型血清学模式。有一个在社会上这种血清学模式没有流行病学特征并没有争议标的这种模式的分子机制。我们在纵向社区队列研究调查了HBsAg和抗-HBs运营商的流行病学特征。这种非典型的血清学模式的患病率为2.93％（四千一百六十九分之一百二十二）在HBsAg阳性的人群。患病率逐渐从40到70岁随年龄增长而增加。对HBeAg阳性和检测HBV DNA的比率均显著高于运营这种模式要比谁是HBsAg阳性，但抗HBs阴性（一百二十二分之二十六诗四千○四十七分之五百九十八载体，P = 0.046;一百二十二分之八十六诗句五百二十九分之二百七十五，P <0.001）。 1年的随访后，载流子的85.19％仍然有共存HBsAg和抗-HBs，载流子的14.81％失去抗-HBs。病毒序列分析表明载体用HBsAg和抗-HBs共存有较高数量的比谁是HBsAg阳性但抗-HBs阴性（2.42节每100个残基的改变1.33，P <0.05）载波的S基因内残基变化。因此，HBsAg和抗-HBs的共存是可能与不良临床结果的风险增加相关联，并且可能与具有基因型异质的HBsAg免疫的变体的唯一的血清学图样。

llau_lhf

病毒变异？

StephenW

llau_lhf 发表于 2015-12-30 07:51
病毒变异？

乙肝病毒在肝脏是一个准种(quasispecies)
Virologists now understand that virus populations are not made of a single member with a defined nucleic acid sequence. Rather, they are dynamic distributions of nonidentical but related members called a quasispecies. It was given this name because the classical definition of species – an interbreeding population of individuals – has little meaning for viruses.This variation, which is a consequence of the error prone nature of viral replication, has since been confirmed using other viral systems.
病毒学家现在知道病毒种群没有由单一构件的与定义的核酸序列。相反，它们是不完全相同的，但相关的成员的动态分布叫做准种。它被赋予这个名字，因为物种的经典定义 - 个人的杂交繁殖人口 - 就没有什么意义了viruses.This变化，这是病毒复制的容易出错的性质，后果，此后一直使用其他病毒系统的证实。

llau_lhf

回复 StephenW 的帖子

多谢啦！

王震宇

很好！

研究方向又跑偏了，我就喜欢看着这帮书呆子犯傻！

newchinabok

老王的粉丝，必须挺

newchinabok

老王，好久不整拉米了，天津单口也不说了，也不和sw掐了，该不会和大家玩深沉吧

newchinabok

老王，？