脉冲与热休克蛋白70和HBxAg树突状细胞诱导乙型肝炎病毒相关

StephenW

Mol Med Rep. 2015 Dec 7. doi: 10.3892/mmr.2015.4654. [Epub ahead of print]
Dendritic cells pulsed with Hsp70 and HBxAg induce specific antitumor immune responses in hepatitis B virus‑associated hepatocellular carcinoma.Wang H1, Feng F1, Wang XP1, Wang RS1, Wu Y1, Zhu MG1, Zhang H1, Zhuang ZX1.
Author information

• 1Department of Oncology, The Second Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215004, P.R. China.
  

AbstractPrevious studies have drawn attention to dendritic cell (DC) vaccines; particularly the application of the tumor‑associated antigen‑targeted DC vaccine. The present study analyzed DCs derived from a normal individual and pulsed the cells with heat shock protein 70 peptide (Hsp70) and/or hepatitis B virus x antigen (HBxAg), a hepatocellular carcinoma (HCC)‑associated antigen. It was then investigated whether this method of vaccination induced strong therapeutic antitumor immunity. The results revealed that the Hsp70/HBxAg complex‑activated phenotype improves the functional maturation of DCs compared with using Hsp70 or HBxAg alone. Compared with either Hsp70 or HBxAg alone, matured DCs pulsed with the Hsp70/HBxAg complex stimulated a high level of autologous T‑cell proliferation and induced HCC‑specific cytotoxic T lymphocytes, which specifically killed HCC cells through a major histocompatibility complex class I mechanism. These results indicated that a vaccination therapy using DCs co‑pulsed with the Hsp70/HBxAg complex is an effective strategy for immunotherapy and may offer a useful approach to protect against HCC.

StephenW

分子医学众议员2015年7月DOI：10.3892 / mmr.2015.4654。 [打印EPUB提前]
脉冲与热休克蛋白70和HBxAg树突状细胞诱导乙型肝炎病毒相关的肝细胞癌特异性的抗肿瘤免疫应答。
王H1，冯F1，王XP1，王RS1，吴Y1，朱MG1，张H1，庄ZX1。
作者信息

    肿瘤学教研室，第二附属医院，苏州大学，苏州，江苏215004，中国公关的。

抽象

以前的研究已经关注到树突状细胞（DC）疫苗;肿瘤相关抗原靶向DC疫苗的特别的应用。本研究中分析来自于正常个体和致敏的细胞热休克蛋白70肽（热休克蛋白70）和/或乙型肝炎病毒X抗原（HBxAg），肝细胞癌（HCC）相关抗原的DCs。然后将调查疫苗接种这种方法是否引起强烈的治疗抗肿瘤免疫。结果表明，所述的Hsp70 / HBxAg复杂活化表型提高DC的功能性成熟，使用的Hsp70或HBxAg单独进行比较。与任一的Hsp70或HBxAg单独相比，成熟的DC脉冲与热休克蛋白70 / HBxAg复杂刺激高水平的自体T细胞的增殖和诱导肝细胞癌特异性细胞毒性T淋巴细胞，通过主要组织相容性复合体I类机构，其特异性地杀死肝癌细胞。这些结果表明，采用DCS接种疗法共同脉冲与热休克蛋白70 / HBxAg复合物是一种有效的策略，免疫治疗，有可能带来以防止肝癌的一种有效手段。

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