HBV基因型与中国西部多民族地区的抗病毒药物的耐药性流行

StephenW

Sci Rep. 2015 Nov 27;5:17413. doi: 10.1038/srep17413.
Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China.Zhang Q1, Liao Y1, Chen J1, Cai B1, Su Z1, Ying B1, Lu X1, Tao C1, Wang L1.
Author information

• 1Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou district, Chengdu 610041, People's Republic of China.
  

AbstractHepatitis B virus (HBV) infection is a critical global health issue and moderately epidemic in Western China, but HBV molecular epidemiology characteristics are still limited. We conducted this study to investigate HBV genotypes and antiviral resistant mutations in this multi-ethnic area. A total of 1316 HBV patients were recruited from four ethnic groups from 2011 to 2013. Genotypes and resistant mutations were determined by Sanger sequencing. Four genotypes (B, C, D and C/D) were identified. Genotype B and C were common in Han population, while genotype D was predominant in Uygurs. Genotype C was the major genotype in both Tibetans and Yis, and recombinant C/D was found in Tibetans only. Lamivudine resistance was common in all populations, especially in Hans with prevalence of 42.8%. Entecavir resistance was barely observed regardless of ethnicity. Genotype C isolates had higher rates of rtA181T/V than genotype B (13.5% vs. 5.1%, P < 0.001), in accordance with higher prevalence of resistance to adefovir (20.0% vs. 9.5%, P < 0.001). While incidence of resistant mutations to other drugs and clinical factors showed no difference among different genotypes. HBV genotypes and resistance-conferring mutations had different geographic and demographic distributions in Western China, which provided molecular epidemiology data for clinical management.


PMID:26612031 [PubMed - as supplied by publisher]

StephenW

。科学众议员2015年11月27日; 5：17413。 DOI：10.1038 / srep17413。
HBV基因型与中国西部多民族地区的抗病毒药物的耐药性流行病学研究。
张一季度，辽Y1，陈J1，蔡B1，苏Z1，B1颖，陆X1，陶C1，L1王。
作者信息

    教研室医学杂志，中国西部医院，四川大学，排名第37位国学巷，成都市武侯区610041，中华人民共和国的。

抽象

乙型肝炎病毒（HBV）感染是一个重要的全球健康问题和中度流行在中国西部，但乙肝病毒分子流行病学特征仍然有限。我们进行这项研究，调查HBV基因型和抗病毒耐药突变在这个多民族地区。共有1316乙肝患者从四个族群被招募从2011年到2013年的基因型和耐药性突变是由Sanger测序确定。 4种基因型（B，C，D和C / D）被确定。 B，C基因型是汉族人群中很常见，而D型是主要的维族人。 C基因型在两个藏族和彝族的主要基因型，重组C / D中发现只有藏人。拉米夫定耐药是常见于所有人群，特别是在汉斯以42.8％患病。恩替卡韦耐药性几乎观察不到不分民族。 C基因型菌株有rtA181T / V比B型（13.5％对5.1％，P <0.001）率较高，按照耐药发病率较高阿德福韦（20.0％对9.5％，P <0.001）。虽然耐药突变其它药物和临床因素的发病率呈现出不同的基因型之间没有差异。 HBV基因型和抗性的突变有不同的地理和人口分布在中国西部地区，其提供的分子流行病学数据，为临床管理。