乙型肝炎病毒X蛋白的功能是肝癌的分子机制

StephenW

Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis.Geng M1, Xin X1, Bi LQ1, Zhou LT1, Liu XH1.
Author information

• 1Ming Geng, Xuan Xin, Li-Quan Bi, Lu-Ting Zhou, Xiao-Hong Liu, Department of Pathology, General Hospital of Jinan Military Command, Jinan 250031, Shandong Province, China.
  

AbstractMany factors are considered to contribute to hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), including products of HBV, HBV integration and mutation, and host susceptibility. HBV X protein (HBx) can interfere with several signaling pathways associated with cell proliferation and invasion, and HBx C-terminal truncation has been suggested to impact the development of HCC. This review focuses on the pathological functions of HBx in HBV-induced hepatocarcinogenesis. As a transactivator, HBx can affect regulatory non-coding RNAs (ncRNAs), including microRNAs and long ncRNAs. HBx is also involved in epigenetic modification and DNA repair. HBx interacts with various signal-transduction pathways, such as the p53, Wnt, and nuclear factor-κB pathways. We conclude that HBx hastens the development of hepatoma.


KEYWORDS: Hepatitis B virus; Hepatitis B virus X protein; Hepatocarcinogenesis; Hepatocellular carcinoma

StephenW

乙型肝炎病毒X蛋白的功能是肝癌的分子机制。
耿M1，X1鑫，毕LQ1，周LT1，刘XH1。
作者信息

    1Ming庚，宣鑫利泉碧，鲁汀洲，小柳红，病理科，济南军区，济南250031，中国山东省总医院。

抽象的

许多因素被认为有助于乙型肝炎病毒（HBV）相关的肝细胞癌（HCC），包括乙型肝炎病毒，乙肝病毒整合和突变，以及宿主易感性产品。 HBV X蛋白（HBx蛋白）可与细胞增殖和侵袭，和HBx的C-末端截短相关的多个信号通路干扰已经提出冲击HCC的发展。这次审查的重点HBx蛋白的乙肝病毒引起肝癌的病理功能。作为一个反式激活，HBx蛋白可影响调节非编码RNA（非编码RNA），包括微RNA和非编码RNA长。 HBx蛋白还参与表观遗传修饰和DNA修复。 HBx的相互作用与各种信号转导途径，如p53和Wnt信号，以及核因子κB途径。我们的结论是HBx的加快而肝癌的发展。
关键词：

乙型肝炎病毒;乙型肝炎病毒X蛋白;肝癌;肝癌