γ-干扰素协会诱导蛋白10基因多态性与HBeAg阳性慢性乙型肝炎

StephenW

Antivir Ther. 2015 Sep 17. doi: 10.3851/IMP2992. [Epub ahead of print]
Association of interferon-gamma inducible protein 10 polymorphism with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B.Limothai U1, Chuaypen N, Khlaiphuengsin A, Posuwan N, Wasitthankasem R, Poovorawan Y, Tangkijvanich P.
Author information

• 1Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  

AbstractBACKGROUND: Interferon-gamma inducible protein 10 (IP-10) plays an important role in clinical outcome of chronic hepatitis B (CHB). This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) G-201A of the IP-10 gene and treatment response to pegylated interferon (PEG-IFN) in patients with HBeAg-positive CHB.
METHODS: We retrospectively analyzed data of patients with HBeAg-positive CHB treated with PEG-IFN for 48 weeks. Virological response (VR) was defined as HBeAg clearance and HBV DNA < 2,000 IU/mL at 24 weeks post-treatment. The SNPs G-201A, IFNL3 (rs12979860) and HLA-DPA1 (rs3077) were assessed.
RESULTS: Among 107 patients, VR was achieved in 45 (42.1%) patients. HBsAg clearance and decline (< 100 IU/mL) were observed in 10 (9.3%) and 22 (20.6%) patients, respectively. The distribution of GG, GA and AA genotypes of G-201A was 76.6%, 19.6% and 3.7%, respectively. Patients with GG genotype, compared to those with non-GG genotype, achieved higher VR rate (48.8% vs. 19.2%; P=0.011), decreased HBsAg (25.6% vs. 4.0%, P=0.019), and demonstrated a trend in HBsAg clearance (11.0% vs. 4%, P=0.294). Patients with GG-genotype had more rapid HBsAg decline and higher baseline serum IP-10 levels than those with non-GG genotype (432.2±339.0 vs. 257.3±145.7 pg/mL, P=0.028). SNPs rs12979860 and rs3077 were not associated with VR. Logistic regression analysis suggested that SNP G-201A was an independent predictor of VR (odds ratio 3.81, 95% confidence interval: 1.31-11.12, P=0.014).
CONCLUSIONS: Data from this study demonstrated for the first time that IP-10 polymorphism is independently associated with treatment response to PEG-IFN in patients with HBeAg-positive CHB.

StephenW

ANTIVIR疗法。 2015年九月17 DOI：10.3851 / IMP2992。 [打印EPUB提前]
γ-干扰素协会诱导蛋白10基因多态性与HBeAg阳性慢性乙型肝炎治疗的反应，以聚乙二醇干扰素
Limothai U1，Chuaypen N，Khlaiphuengsin A，Posuwan N，Wasitthankasem R，Poovorawan Y，Tangkijvanich P.
作者信息

    卓越1Center在临床病毒学杂志，儿科，医学系，朱拉隆功大学，曼谷，泰国部。

抽象的
背景：

干扰素γ诱导蛋白10（IP-10）起着慢性乙型肝炎（CHB）的临床结果中起重要作用。本研究旨在探讨患者HBeAg阳性慢性乙型肝炎的单核苷酸多态性（SNP）G-201A的IP-10基因和治疗反应聚乙二醇干扰素（PEG-IFN）之间的关联。
方法：

回顾性分析患者的数据与PEG-IFN治疗48周HBeAg阳性慢性乙型肝炎。病毒学应答（VR）被定义为HBeAg清除和HBV DNA <2000 IU / mL的在24周治疗后。单核苷酸多态性G-201A，IFNL3（rs12979860）和HLA-DPA1（rs3077）进行了评估。
结果：

其中107例患者，VR在45（42.1％）的患者达到了。 HBsAg清除和下降（<100 IU /毫升），观察在10（9.3％）和22（20.6％）的患者，分别。 GG，GA和G-201A的AA基因型分布率为76.6％，分别为19.6％和3.7％。患者GG基因型，比起那些与非GG型，实现了较高的VR率（48.8％对19.2％，P = 0.011），降低的HBsAg（25.6％对4.0％，P = 0.019），并表现出一种趋势在HBsAg清除（11.0％比4％，P = 0.294）。患者以GG-基因型更快速的HBsAg下降和较高的基线血清的IP-10水平比用非GG基因型（432.2±339.0 257.3对比±145.7微克/毫升，P = 0.028）。单核苷酸多态性rs12979860和rs3077没有与虚拟现实相关联的。 Logistic回归分析表明，SNP G-201A是VR（比值比3.81，95％置信区间：1.31-11.12，P = 0.014）的独立预测因子。
结论：

从本研究的数据显示在第一次该IP-10多态性独立地与治疗响应于PEG-IFN在例HBeAg阳性CHB相关联。