管理及预后肝癌：什么20年来发生了变化？

StephenW

The management and prognosis of patients with hepatocellular carcinoma: What has changed in 20 years?

    Sun Young Yim1, Yeon Seok Seo1,*, Chang Ho Jung1, Tae Hyung Kim1, Jae Min Lee1, Eun Sun Kim1, Bora Keum1, Young Kul Jong1, Hyunggin An3, Ji Hoon Kim1, Hyung Joon Yim1, Dong Sik Kim2, Yoon Tae Jeen1, Jong Eun Yeon1, Hong Sik Lee1, Hoon Jai Chun1, Kwan Soo Byun1, Soon Ho Um1, Chang Duck Kim1 andHo Sang Ryu1

DOI: 10.1111/liv.12960

This article is protected by copyright. All rights reserved.

Issue
Cover image for Vol. 35 Issue 9
Liver International

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Additional Information(Show All)


    1    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
    2    Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea University College of Medicine, Seoul, Korea
    3    Department of Biostatistics, Korea University College of Medicine, Seoul, Korea

* Correspondence:
Yeon Seok Seo, MD, PhD
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea
Fax: +82-2-953-1943; Tel.: +82-2-920-6555; E-mail: [email protected]

    This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/liv.12960

Keywords:

    Hepatocellular carcinoma;hepatitis B virus;radiofrequency ablation

Abstract
Background and aims

There has been remarkable progress in the management of hepatocellular carcinoma (HCC) during the last several decades but its effect on the prognosis of HCC patient needs clarification. We analyzed the changes that affected prognosis of HCC patients diagnosed over two different eras.
Methods

A retrospective study of 1318 patients diagnosed with HCC from 1986 to 2012 was conducted. Analysis was done according to two cohorts, cohort 1 (patients diagnosed with HCC from 1986 to 1992) and cohort 2 (patients diagnosed from 2006 to 2012).
Results

Hepatitis B virus was the most common cause of liver disease for both cohorts (66.2% and 66.0%). The proportion of patients with Barcelona Clinic Liver Cancer stage 0/A was significantly lower in cohort 1 than in cohort 2 (14.4% vs. 39.5%, P<0.001). The proportions of patients diagnosed during surveillance and general health-check were significantly higher in cohort 2 than in cohort 1 (28.6% vs. 10.6% and 26.3% vs. 7.9%, respectively) while those diagnosed during symptomatic evaluation was significantly higher in cohort 1 than in cohort 2 (45.1 vs. 81.4%, P<0.001). Surgical resection rate was similar between the two cohorts (26.1% vs 26%) while the transcatheter arterial chemoembolization rate which was highest in cohort 1 (40.6%) was overtaken by radiofrequency ablation in cohort 2 (55%) at BCLC stage 0/A. Median survival duration in cohort 2 was significantly longer than cohort 1 (65.0 vs. 7.9 months, P<0.001).
Conclusions

Implementation of national cancer surveillance and the advancement of treatment modalities have likely led to the early detection of HCC and improvements in prognosis over the last 20 years.

This article is protected by copyright. All rights reserved.

StephenW

管理及预后肝癌：什么20年来发生了变化？

    孙杨Yim1，延锡SEO1，*，张豪Jung1，太亨Kim1，宰敏Lee1，朴恩善Kim1，宝来Keum1，扬库尔Jong1，Hyunggin AN3，稽勋Kim1，亨俊Yim1，董植Kim2，尹太Jeen1，金正恩Yeon1，香港啬Lee1，勋洁春1，关秀Byun1，不久何UM1，张鸭子Kim1 andHo桑Ryu1

DOI：10.1111 / liv.12960

这篇文章是受版权保护的。版权所有。

问题
封面图片卷。 35第9期
肝国际

接受第（接受，未编辑的文章在网上和可引用出版。最后编辑记录的排版本将出现在未来的。）

其他信息（显示所有）


    胃肠病学和肝病，内科，中医的韩国大学，韩国首尔的1处
    HBP外科2司和肝移植，外科，医学，韩国首尔，韩国大学
    生物统计学3系，医学院，首尔，韩国高丽大学学院

*通讯：
延锡徐博士
胃肠病学和肝病，内科，医学高丽大学学院，126-1，亚南洞5-GA，城北区厅，首尔136-705，韩国分部
传真：+ 82-2-953-1943;电话：+ 82-2-920-6555;电子信箱：[email protected]

    这篇文章已被接受发表，并经过充分的同行评审，但经过审稿，排版，分页和校对过程中，这可能会导致这个版本和记录的版本之间的差异还没有。请引用这篇文章的DOI：10.1111 / liv.12960

关键词：

    肝细胞癌;乙型肝炎病毒;射频消融术

抽象的
背景和目的

在过去的几十年里出现了肝细胞癌（HCC）的管理显着进展，但其对肝癌患者的预后效果有待澄清。我们分析了影响肝癌患者确诊了两个不同时代的预后的变化。
方法

1318例确诊为肝癌1986年至2012年回顾性研究进行。分析是根据两个组，第1组（例确诊为肝癌1986年至1992年）和队列2（例确诊2006至2012年）完成的。
结果

乙型肝炎病毒是肝病为两个队列（66.2％和66.0％）的最常见原因。患者巴塞罗那临床肝癌阶段0 / A的比例显著降低队列1比队列2（14.4％对39.5％，P <0.001）。患者监测和一般健康检查中诊断的比例分别为显著高于队列2比1组（28.6％对10.6％和26.3％和7.9％），而在有症状的评估诊断是显著高于队列1比队列2（45.1对比81.4％，P <0.001）。手术切除率分别为两个同伙（26.1％比26％）相似，而肝动脉化疗栓塞速率最高的是第1组（40.6％）在BCLC 0级/ A落后于射频消融在队列2（55％） 。中位生存期在队列2是显著高于第1组（65.0主场迎战7.9个月，P <0.001），更长的时间。
结论

国家癌症监测和治疗模式的进步的实施可能已经导致预后的早期检测肝癌和改进的在过去的20年。

这篇文章是受版权保护的。版权所有。

果农

管理及预后肝癌：什么20年来发生了变化？

果农

版权所有。

MPTP

回复 StephenW 的帖子

译者辛苦了，就是翻译得太生硬了，而且，错误太多，就连“摘要”，这样的基本词汇都没有正确，“结果”部份，更是没法读出原意来，你的外语水平有待提高啊。

StephenW

回复 MPTP 的帖子

你是对的, 翻译是非常差. 这个翻译是由谷歌机器翻译(Google Translate),应仅用来作为一个导引.
请修正.