怀孕和免疫系统：总体概述和胃肠病视角

StephenW

Date: 07 May 2015
Pregnancy and the Immune System: General Overview and the Gastroenterological Perspective

    Tomer Adar, Sorina Grisaru-Granovsky, Ami Ben Ya’acov, Eran Goldin, Ariella Bar-Gil Shitrit

Author Affiliations

        1. Digestive Disease Institute, Shaare Zedek Medical Center, Affiliated with the School of Medicine in the Hebrew University of Jerusalem, 12 Bayit St., 91031, Jerusalem, Israel
        2. Obstetrics and Gynecology Department, Shaare Zedek Medical Center, Affiliated with the School of Medicine in the Hebrew University of Jerusalem, Jerusalem, Israel


Abstract

Pregnancy represents a unique immune tolerant condition that cannot be attributed merely to generalized immunosuppression. A variety of mechanisms have been described, ranging from the non-self recognition, immunomodulation of specific inflammatory cell populations and a Th2-directed shift of the immune response, which are mediated by both localized and systemic mediators. Furthermore, an inflammatory response directed toward the conceptus is no longer considered an obligatory deleterious response; instead, it is considered an important factor that is necessary for normal growth and development. These immunomodulatory changes during pregnancy may also affect concurrent conditions and alter the course of inflammatory diseases. Herein, we review the main immunomodulatory changes that occur during pregnancy and their effect on coexisting inflammatory conditions, with a specific focus on gastrointestinal disorders.
Digestive Diseases and Sciences Digestive Diseases and Sciences Look

llau_lhf

没结论没细节？

StephenW

回复 llau_lhf 的帖子

这是一个回顾(review)，没有摘要.

llau_lhf

回复 StephenW 的帖子

哦，谢谢！