PD-L1对患者的CD4 + CD25 + Foxp3 +调节性T细胞与慢性HBV感染及其与

StephenW

Viral Immunol. 2015 Aug 12. [Epub ahead of print]
Expression of PD-L1 on CD4+CD25+Foxp3+ Regulatory T Cells of Patients with Chronic HBV Infection and Its Correlation with Clinical Parameters.Feng C1, Cao LJ1, Song HF1,2,3, Xu P2,3, Chen H2,3, Xu JC2,3, Zhu XY2,3, Zhang XG1,4, Wang XF1.
Author information

• 11 Department of Biochemistry and Molecular Biology, School of Biology and Basic Medical Sciences, Soochow University , Suzhou, China .
• 22 Central Laboratory, The Affiliated Infectious Hospital of Soochow University , Suzhou, China .
• 33 Key Laboratory of Infection and Immunity of Suzhou City , Suzhou, China .
• 44 The First Affiliated Hospital of Soochow University , Suzhou, China .
  

AbstractRegulatory T cells (Tregs) play a pivotal role in suppressing specific antiviral immune responses during the progression of chronic hepatitis B virus infection (CHB) as well as tumorigenesis. Programmed death-1 ligand-1 (PD-L1) expressed on Tregs can transduce an inhibitory signal into effector T cells through interacting with programmed death-1 (PD-1). However, in CHB patients, the clinical significance of PD-L1 expression on Tregs has not been clearly described. This study investigated the frequency of circulating Tregs and PD-L1 expression on Tregs and analyzed their correlations with clinical parameters. The data show that both the frequency of CD4+CD25+FoxP3+ Tregs and PD-L1 expression on Tregs in the peripheral blood increased significantly in CHB patients when compared with healthy controls. At the same time, it is shown that PD-L1 expression on Tregs was positively correlated with the percentage of Tregs in CHB patients. Moreover, the results demonstrated that both Treg frequency and PD-L1 expression on Tregs positively correlated with the levels of alanine aminotransaminase (ALT) and aspartate aminotransferase (AST), both of which are indicators of the extent of liver injury. Taken together, these findings suggest that PD-L1 on Tregs might contribute to progression of hepatitis B virus infection through mediating the inhibitory function of Tregs. Thereby, blockade of interaction between Treg-expressing PD-L1 and PD-1 on effector T cells may be adopted as a potential therapeutic approach in CHB.

StephenW

病毒免疫。 2015年12月[EPUB的提前打印]
PD-L1对患者的CD4 + CD25 + Foxp3 +调节性T细胞与慢性HBV感染及其与临床参数的表达。
丰C1，曹LJ1，宋HF1,2,3，徐P2,3，陈H2,3，徐JC2,3，朱XY2,3，张XG1,4，王XF1。
作者信息

    生物化学与分子生物学，生物学院和基础医学院，苏州大学，苏州，中国的11部。
    22中心实验室，苏州大学，苏州，中国的附属传染病医院。
    感染与苏州市，苏州市，中国免疫的33个重点实验室。
    44苏州大学，苏州，中国第一附属医院。

抽象

调节性T细胞（Treg细胞）发挥在慢性乙型肝炎病毒感染（CHB）以及肿瘤进展期间抑制特定的抗病毒免疫应答中具有关键作用。程序性死亡1配体1（PD-L1）上的Treg表达可以通过与程序性死亡-1（PD-1）的交互转导的抑制性信号转换成效应T细胞。然而，在慢性乙肝患者，PD-L1表达对调节性T细胞的临床意义尚未明确说明。这项研究调查了对循环Tregs的调节性T细胞和PD-L1表达的频率和分析了它们的相关性与临床参数。数据表明，CD4 + CD25 +的FoxP3 +调节和PD-L1的表达上的Treg既在外周血的频率当与健康对照相比显著慢性乙型肝炎患者增加。同时，它表明，在调节性T细胞PD-L1的表达与调节性T细胞的慢性乙型肝炎患者的百分比相关。此外，结果表明，二者的Treg频率和PD-L1的表达上的Treg正丙氨酸aminotransaminase（ALT）和天冬氨酸转氨酶（AST）的水平，这两者都是肝损伤的程度的指标相关。两者合计，这些研究结果表明，对调节性T细胞的PD-L1可能通过介导的Treg的抑制功能有助于乙型肝炎病毒感染的进展。从而，对效应T细胞的Treg表达的PD-L1和PD-1之间的相互作用的阻断可以被采用作为在CHB一个潜在的治疗方法。