瞬时弹性成像评估单乙肝病毒感染肝纤维化的表现。

StephenW

Hepatol Int. 2015 Jul 18. [Epub ahead of print]
Performance of transient elastography assessing fibrosis of single hepatitis B virus infection: a systematic review and meta-analysis of a diagnostic test.Xu X1, Su Y, Song R, Sheng Y, Ai W, Wu X, Liu H.
Author information

• 1Department of Epidemiology and Health Statistics, School of Public Health, China Medical University, Shenyang, 110001, People's Republic of China, [email protected].
  

AbstractINTRODUCTION: Transient elastography has good diagnostic accuracy for predicting fibrosis and cirrhosis related to hepatitis B virus. However, the enrolled subjects in some studies have also included chronic hepatitis B patients with chronic hepatitis C coinfection or other etiologies of liver diseases. This might under- or overestimate the role of transient elastography in chronic hepatitis B patients.
METHODS: A systematic review was conducted on records in PubMed, EMBASE and the Cochrane Library electronic databases until 31 December 2013. We systematically assessed the effectiveness and accuracy of transient elastography for predicting the fibrosis and cirrhosis of the single hepatitis B virus. The questionnaire for quality assessment of diagnostic accuracy studies was used.
RESULTS: In this meta-analysis, out of 257 articles evaluated for eligibility, 165 satisfied the predetermined inclusion criteria for meta-analysis. Eventually, our final data set for the meta-analysis contained 19 studies. The areas under the summary receiver-operating characteristic curve for transient elastography of significant fibrosis and cirrhosis were 0.8225 and 0.9108, respectively. The pooled diagnostic odds ratios for transient elastography of significant fibrosis and cirrhosis were 11.19 (95 % CI 6.63-18.89) and 26.87 (95 % CI 17.88-40.38), respectively. In Europe, the areas of significant fibrosis and cirrhosis were 0.803 and 0.905; those in Asia were 0.871 and 0.914, respectively.
CONCLUSIONS: Based on this meta-analysis we claim that liver stiffness measurement using transient elastography has good diagnostic accuracy for predicting single hepatitis B virus-related significant fibrosis and cirrhosis, especially in Asian populations.

StephenW

肝脏病诠释。 2015年18月[EPUB的提前打印]
一个系统的回顾和荟萃分析诊断测试：瞬时弹性成像评估单乙肝病毒感染肝纤维化的表现。
徐X1，苏Y，宋R，盛Y，艾W，吴X，刘H.
作者信息

    教研室流行病与卫生统计学，公共卫生，中国医科大学，沉阳，110001，中华人民共和国，[email protected]学院。

抽象
简介：

瞬时弹性有很好的诊断准确预测纤维化和肝硬化与乙肝病毒。然而，在一些研究中已登记受试者也包括慢性乙型肝炎患者的慢性丙型肝炎共感染或肝脏疾病的其他病因。这可能不足或高估瞬时弹性成像的慢性乙型肝炎患者的作用。
方法：

系统回顾了2013年12月进行的考研中，文摘和Cochrane图书馆电子数据库记录，直到31日，我们系统地评估预测单乙肝病毒的肝纤维化和肝硬化瞬时弹性成像的有效性和准确性。调查问卷，诊断性研究的质量评估使用。
结果：

在此荟萃分析，从257条评估资格，165满足预定的纳入标准进行Meta分析。最后，我们的荟萃分析最终数据集包含19项研究。为显著纤维化和肝硬化的瞬时弹性成像摘要受试者工作特征曲线下面积分别为0.8225和0.9108，分别为。为显著纤维化和肝硬化的瞬时弹性成像汇集诊断比值比分别为11.19（95％CI 6.63-18.89）和26.87（95％CI 17.88-40.38），分别。在欧洲，显著纤维化和肝硬化的面积分别为0.803和0.905;那些在亚洲为0.871和0.914，分别。
结论：

在此基础上汇总分析，我们主张用瞬时弹性成像肝脏硬度测量具有良好的诊断准确预测单乙肝病毒相关显著纤维化和肝硬化，尤其是在亚洲人群。