最佳的疫苗接种程序为健康的成年人在中国。

StephenW

Hum Vaccin Immunother. 2015 Jul 9:0. [Epub ahead of print]
Optimal vaccination program for healthy adults in China.
Yao J1, Qiu Y, Chen Y, Jiang Z, Shen L, Shan H, Dai X, Li Q, Liu Y, Ren W, Ren J.
Author information
    1a Zhejiang Provincial Center for Disease Control and prevention , 310051 , Hangzhou , Zhejiang , China.


Abstract
OBJECTIVE:

There is still no suitable routine hepatitis B immunization strategy for adults in China. To establish an optimal vaccination schedule for healthy adults, we investigated various schedules in healthy adults.
METHODS:

In this randomized 5143 healthy adults received 10 μg hepatitis B vaccine at 0, 1 and 3 months(group A), 0, 1 and 6 months(group B), or 0, 1 and 12 months(group C). Blood samples were collected after 1 month and 12 months after the third dose. The geometric mean titer (GMT), seroconversion rate (levels of anti-HBs ≥10 mIU/mL) and high response rate (levels of anti-HBs ≥100 mIU/mL) were assayed.
RESULTS:

In our study, 2438 healthy adults finished the full vaccination program and follow-up. The seroconversion/sero-protective rate of groups A-C at one and twelve month after administration of the third vaccine dose was 100%, 99.9% and 97.9% verse 64.9%, 75.7% and 79.0%, respectively. GMT for anti-HBs tested in group A to C within 1 or 12 month after the third vaccination was 213.16, 432.58 and 451.47 mIU/ml verse 22.07, 46.70 and 56.18 mIU/ml, respectively. There were significant differences of seroconversion/sero-protective rate and GMT among the three groups (p<0.01).
CONCLUSIONS:

Given the high anti-HBs seroconversion rate and GMT in all three groups, a flexible schedule for Hepatitis B vaccine should be recommended to adults, but 0-1-12 schedule is a better choice.
KEYWORDS:

Adult vaccination; anti-HBs titers; hepatitis B vaccine; immunogenicity

StephenW

呜呜免疫治疗疫苗免疫。 2015年07月09日：0。 [打印EPUB的提前]
最佳的疫苗接种程序为健康的成年人在中国。
姚J1，邱Y，陈Y，江Z，沉L，山H，戴X，李Q，刘毅，任W，仁J.
作者信息
    1A浙江省疾病预防控制中心和预防，310051，杭州，浙江，中国的。


抽象
目的：

目前还没有合适的常规乙肝疫苗接种策略的成年人在中国。要建立健康的成年人的最佳疫苗接种计划，我们调查的健康成人不同的时间表。
方法：

在这个随机5143名健康成人接受10微克的乙肝疫苗在0,1和3个月（A组），0,1和6个月（B组），或0,1和12个月（C组）。 1个月和12个月的第三次剂量后后收集血液样品。几何平均滴度（GMT），血清转换率（抗-HBs≥10MIU /毫升的水平），高响应率（抗-HBs≥100MIU /毫升水平）进行测定。
结果：

在我们的研究中，2438名健康成年人完成了完整的疫苗接种计划和随访。在同一和12个月第三疫苗剂量的施用后的血清转换/血清保护基的AC率为100％，99.9％和97.9％节64.9％，75.7％和79.0％之间。格林尼治标准​​时间的抗-HBs A组第三次接种后分别检测到C 1或12个月内为213.16，432.58和451.47 MIU / ml的诗句22.07，46.70和56.18 MIU /毫升。有三组间血清学转换/血清保护率和GMT（P <0.01）显著差异。
结论：

鉴于高抗-HBs阳转率和GMT三组，一个灵活的时间表，乙肝疫苗应该被推荐到成人，但0-1-12时间表是一个更好的选择。
关键词：

成人接种;抗-HBs效价;乙肝疫苗;免疫原性