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J Gastroenterol Hepatol. 2015 Jun 11. doi: 10.1111/jgh.13020. [Epub ahead of print]
Improvement of liver function and non-invasive fibrosis markers in hepatitis B virus-associated cirrhosis: 2 years of entecavir treatment.Shin SK1, Kim JH2, Park H1, Kwon OS1, Lee HJ3, Yeon JE3, Byun KS3, Suh SJ4, Yim HJ4, Kim YS1, Kim JH1.
Author information
- 1Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, South Korea.
- 2Department of Internal Medicine, Konkuk University School of Medicine, Seoul, South Korea.
- 3Department of Internal Medicine, Korea University Guro Hospital, Seoul, South Korea.
- 4Department of Internal Medicine, Korea University Ansan Hospital, Ansan, South Korea.
AbstractBACKGROUND AND AIM: Entecavir (ETV) induces biochemical and histologic improvement of the liver in patients with chronic hepatitis B. This study aimed to confirm that 2 years of ETV treatment improves liver function and non-invasive fibrosis markers in patients with hepatitis B virus (HBV)-associated cirrhosis.
METHODS: A total 472 naïve patients with HBV-associated cirrhosis was treated with ETV for at least 2 years, between March 2007 and December 2012. Model for end-stage liver disease (MELD) and Child-Pugh (CP) score were used to evaluate the improvement of liver function. Aspartate transaminase to platelet ratio index (APRI), FIB-4 index, and fibrosis index (FI) were used to evaluate the improvement of fibrosis.
RESULTS: The final 370 of 472 patients with HBV-associated cirrhosis were enrolled. Mean age was 51 ± 10 years and 240 patients (64.9%) were men. The distribution of CP class was 71.1% in A, 24.6% in B, and 4.3% in C. Mean MELD and CP score changed over the study period from 8.5 ± 4.6 to 6.2 ± 4.2 (P < 0.001) and from 6.2 ± 1.6 to 5.6 ± 0.9 (P < 0.001), respectively. APRI, FIB-4 index, and FI changed from 3.6 ± 4.5 to 1.5 ± 1.5 (P < 0.001), from 7.0 ± 6.2 to 3.9 ± 2.8 (P < 0.001), and from 3.3 ± 0.9 to 2.5 ± 1.1 (P < 0.001), respectively.
CONCLUSIONS: After 2 years of treatment, entecavir improves liver function and non-invasive fibrosis markers in patients with HBV- associated cirrhosis.
This article is protected by copyright. All rights reserved.
KEYWORDS: entecavir; hepatitis B virus; liver fibrosis; liver function
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