预防母亲传染给孩子的做法在中国南方三省有效性

StephenW

Hum Vaccin Immunother. 2015 Jun 19:0. [Epub ahead of print]
Effectiveness of prevention of mother-to-child transmission practice in three provinces of Southern China.Wang F1, Zheng H, Zhang G, Ding Z, Li F, Zhong G, Chen Y, Jia Y, Miao N, Wu Z, Sun X, Li L, Liang X, Cui F.
Author information

• 1a Chinese Center for Disease Control and Prevention , Beijing , China.
  

AbstractBACKGROUND: Vaccination in prevention mother-to-child transmission (PMTCT) of hepatitis B has been recommended since plasma-derived hepatitis B vaccines became available in China in 1986; however, less study evaluated practice effectiveness of PMTCT systematically.
OBJECTIVE: We conducted a prospective survey to evaluate the effectiveness of PMTCT practices in 3 provinces of southern China.
METHODS: We selected prefectures with low timely birth dose coverage in Yunnan, Guangxi, and Hunan provinces. Infants born to HBsAg positive mothers were evaluated at 7-12 months of age. We tested hepatitis B virus (HBV) surface antigen (HBsAg) and HBV e antigen (HBeAg) of mothers and tested HBsAg of infants born to HBsAg positive mothers using Enzyme-linked Immunosorbent Assay (ELISA) at provincial CDC laboratories. We used logistic regression analysis to analyze the risk factors for HBV infection.
RESULTS: Among 3,094 infants born to HBsAg positive mothers, 172 were positive for HBsAg (5.6%). HBeAg status of pregnant women, timely birth dose (TBD) of hepatitis B vaccine were major predictors for HBV infection of infants.
CONCLUSIONS: PMTCT practices greatly reduced the prevalence of HBsAg among infants born to HBsAg positive mothers China. However, the effectiveness of strategies used in PMTCT varied. HBsAg screening for pregnant women, monitoring of infants born to HBsAg positive mother should be enhanced to evaluate the effectiveness of program.


KEYWORDS: Effectiveness; Hepatitis B; Immunoprophylaxis; Mother-to-child Transmission; Prevention

StephenW

呜呜免疫治疗疫苗免疫。 2015年6月19日：0。 [打印EPUB的提前]
预防母亲传染给孩子的做法在中国南方三省有效性。
王F1，郑H，张G，丁Z，李楼忠G，陈Y，贾ÿ，苗N，吴Z，孙X，李升，梁X，崔F.
作者信息

    1A中国疾病预防控制中心和预防，北京，中国为。

抽象
背景：

接种乙肝预防母亲传染给孩子（母婴阻断）已建议，因为血浆源性乙肝疫苗，于1986年成为在中国上市;然而，少研究评价系统的预防艾滋病母婴传播的实践中的有效性。
目的：

我们进行了一项前瞻性调查，以评估在中国南部的3省预防艾滋病母婴传播措施的有效性。
方法：

我们选择的都道府县低出生及时剂量覆盖云南，广西，湖南等省。出生于HBsAg阳性母亲的婴儿在7-12个月的年龄进行了评价。我们测试乙型肝炎病毒（HBV）表面抗原（HBsAg）和母亲的乙肝病毒e抗原（HBeAg）和测试所生采用酶联免疫吸附试验（ELISA）在省疾控中心实验室HBsAg阳性母亲的新生儿乙肝表面抗原。我们使用logistic回归分析来分析危险因素的HBV感染。
结果：

在出生于HBsAg阳性母亲的新生儿3,094，172是HBsAg阳性（5.6％）。孕妇HBeAg状态，乙肝疫苗的及时诞生剂量（TBD）是主要的预测HBV感染的婴儿。
结论：

预防艾滋病母婴传播的做法大大降低了乙肝表面抗原流行率所生HBsAg阳性母亲的新生儿中国之间。然而，在母婴阻断使用策略的有效性变化。乙肝表面抗原筛查的孕妇，所生的监测对HBsAg阳性母亲的新生儿应加强评估计划的成效。
关键词：

有效性;乙型肝炎;免疫预防;母亲传染给孩子;预防