姜黄素瞄准多种途径暂停肝星状细胞活化：更新机制体外和

StephenW

Digestive Diseases and Sciences
June 2015, Volume 60, Issue 6, pp 1554-1564
Date: 23 Dec 2014
Curcumin Targets Multiple Pathways to Halt Hepatic Stellate Cell Activation: Updated Mechanisms In Vitro and In Vivo

    Youcai Tang


        1. Department of Pediatrics, The Second Affiliated Hospital, Zhengzhou University, 2 Jingba Road, Zhengzhou, 450014, Henan, China
        2. Department of Pediatrics, Saint Louis University School of Medicine, 1100 South Grand Boulevard, Saint Louis, MO, 63104, USA



Abstract

Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease, which is often accompanied by obese and/or type II diabetes mellitus. Approximately one-third of NASH patients develop hepatic fibrosis. Hepatic stellate cells are the major effector cells during liver fibrogenesis. Advanced liver fibrosis usually proceeds to cirrhosis and even hepatocellular carcinoma, leading to liver failure, portal hypertension and even death. Currently, there are no approved agents for treatment and prevention of liver fibrosis in human beings. Curcumin, the principal curcuminoid of turmeric, has been reported to show antitumor, antioxidant, and anti-inflammatory properties both in in vitro and in vivo systems. Accumulating data shows that curcumin plays a critical role in combating liver fibrogenesis. This review will discuss the inhibitory roles of curcumin and update the underlying mechanisms by which curcumin targets in inhibiting hepatic stellate cell activation.

StephenW

消化道疾病与科学
2015年6月，第60卷，第6期，第1554至1564年
日期：2014年12月23日
姜黄素瞄准多种途径暂停肝星状细胞活化：更新机制体外和体内

    唐王有才


        儿科，第二附属医院，郑州大学，Jingba路2号，郑州，450014，河南省，中国的1系
        儿科系，圣路易斯大学医学院，1100南非盛大大道，圣路易斯，密苏里州，63104，美国



抽象

非酒精性脂肪性肝炎（NASH）是非酒精性脂肪肝疾病，其通常伴随着肥胖和/或II型糖尿病的高级形式。大约有三分之一NASH患者的制定肝纤维化。肝星状细胞是在肝纤维化的主要效应细胞。晚期肝纤维化通常前进到肝硬化甚至肝癌，导致肝衰竭，门脉高压，甚至死亡。目前，有用于治疗和预防在人类肝纤维化没有批准代理。姜黄素，姜黄的主要类姜黄素，已经报道表明抗肿瘤，抗氧化，和抗炎性质都在体外和体内系统。累积的数据表明，姜黄素在打击肝纤维化的关键作用。本次审查将讨论姜黄素的抑制的作用和更新底层机制，其中姜黄素抑制肝星状细胞活化目标。

君看一叶舟

文章将谈论姜黄素能抑制肥胖症脂肪肝导致的肝纤维化机制。

君看一叶舟

本文似乎和HBV没多大关系。