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肝胆相照论坛 论坛 学术讨论& HBV English IL-10的生产在慢性乙型肝炎病毒感染的调节性B细胞的作用 ...
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IL-10的生产在慢性乙型肝炎病毒感染的调节性B细胞的作用 [复制链接]

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发表于 2015-5-17 12:49 |只看该作者 |倒序浏览 |打印
Role of IL-10-Producing Regulatory B Cells in Chronic Hepatitis B Virus Infection

    Yanping Gong, Chao Zhao, Peng Zhao, Meifang Wang, Guoqiang Zhou, Fu Han, Yanhong Cui, Jianping Qian, Hongxing Zhang, Huaimin Xiong, Jianhua Sheng, Tingwang Jiang


        1. Institution for Laboratory Medicine, Changshu, China
        2. Department of Infectious Diseases, No.2 People’s Hospital, Changshu, 215500, China
        3. Department of Infectious Diseases, Bejing 302 Hospital, Bejing, 100039, China

Abstract
Background

A subset of interleukin (IL)-10-producing regulatory B (Breg) cells that suppress T-cell-mediated immunity was recently identified; however, their role in chronic hepatitis B (CHB) remains elusive.
Aim

To explore the possible role of Breg in the interaction with Th cells and consequent pathogenesis of CHB.
Methods

The prevalence of Breg as well as 3 major effector T-cell subsets—CD4+CD25highFoxp3+ regulatory T (Treg) cells, T helper 1 cells (Th1), and T helper 2 cells (Th2)—was assessed in the peripheral blood of 31 patients with CHB, 28 patients with acute hepatitis B (AHB), and 25 healthy controls (HC).
Results

Compared to patients with AHB and HC, the prevalence of Breg and Treg cells and the concentration of IL-10 in the supernatant of cultured peripheral blood mononuclear cells (PBMCs) were greatly increased in patients with CHB. A significantly decreased proportion of Th1 cells was also observed in patients with CHB and was demonstrated to have a negative correlation with the prevalence of Breg. Furthermore, depletion of Treg cells in the PBMCs of patients with CHB did not alter the frequency of Breg cells or their ability to produce IL-10, indicating little, if any, impact of Treg cells on the generation and maintenance of Breg cells.
Conclusions

Our data indicate that increased Breg cells might be a major source of elevated IL-10 in CHB and represent a critical and independent regulatory force in the development of impaired anti-HBV immunity, consequently contributing to the pathogenesis of CHB.

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62111 元 
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30437 
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2022-12-28 

才高八斗

2
发表于 2015-5-17 12:50 |只看该作者

IL-10的生产在慢性乙型肝炎病毒感染的调节性B细胞的作用

    延平宫,抄着,碰着,张美芳王,周国强,赴韩,崔嫣红,钱建平,张红星,王怀民雄,建华生,Tingwang江


        1.机构对检验医学,常熟,中国
        传染病系,第二人民医院,常熟,215500,中国
        传染病系3,北京302医院,北京,100039中国

抽象
背景

白细胞介素(IL)的子集-10生产监管B(BREG)细胞抑制T细胞介导的​​免疫最近被确定;然而,它们在慢性乙型肝炎(CHB)的作用仍然遥遥无期。
目的

探索与Th细胞及慢性乙型肝炎的发病因之互动BREG可能发挥的作用。
方法

BREG的流行以及3个主要的效应T细胞亚群,CD4 + CD25highFoxp3 +调节性T(Tre​​g细胞)细胞,T辅助细胞1细胞(Th1细胞)和T辅助细胞2细胞(Th2细胞)-was在31外周血评估慢性乙型肝炎患者,28例急性乙型肝炎(AHB),和25名健康对照(HC)。
结果

相比患者AHB和HC,BREG和Treg细胞的患病率和IL-10在培养外周血单核细胞(PBMC)的上清液中的浓度在患者大大增加慢性乙型肝炎。 Th1细胞的显著下降比例也观察到CHB患者和被证明有与BREG的患病率呈负相关。此外,Treg细胞在患有慢性乙型肝炎的PBMC中的耗尽不改变BREG细胞或它们的产生IL-10的能力的频率,表示小,如果有的话,Treg细胞上BREG细胞的产生和维护的影响。
结论

我们的数据表明,增加BREG细胞可能是升高的IL-10的CHB的主要来源,并代表了关键和独立监管力受损的抗乙肝免疫的发展,从而促进CHB的发病机制。
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