生存利益与IMRT继窄缘切除术的肝癌患者靠近大血管

StephenW

Original Article
Survival Benefit with IMRT Following Narrow-Margin Hepatectomy in Patients with Hepatocellular Carcinoma Close to Major Vessels

    Wei-Hu Wang1,†, Zhi Wang1,†, Jian-Xiong Wu2,†, Tao Zhang1, Wei-Qi Rong2, Li-Ming Wang2, Jing Jin1, Shu-Lian Wang1, Yong-Wen Song1, Yue-Ping Liu1, Hua Ren1, Hui Fang1, Wen-Qing Wang1, Xin-Fan Liu1, Zi-Hao Yu1 andYe-Xiong Li1,*

DOI: 10.1111/liv.12857

This article is protected by copyright. All rights reserved.

Issue
Cover image for Vol. 35 Issue 5
Liver International

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

    1    Departments of Radiation Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences
    2    Abdominal Surgery, Cancer Hospital and Institute, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)

    †    Authors share co-first authorship

*Corresponding author: Ye-Xiong Li, MD, Department of Radiation Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021, P.R. China. Tel: (+86) 10-87788860; Fax: (+86) 10-67706153; E-mail:[email protected]

    This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/liv.12857
   

Abstract
Purpose

To investigate the role of postoperative intensity-modulated radiotherapy (IMRT) in patients receiving narrow-margin hepatectomy for hepatocellular carcinoma (HCC) located close to the major vessels.
Methods

This exploratory study involved 181 HCC patients. Of them, 116 were treated with narrow-margin (<1.0 cm) hepatectomy. Thirty-three of the 116 underwent postoperative IMRT (Group A), while 83 did not receive radiotherapy (Group B). The remaining 65 patients underwent wide-margin (≥1.0 cm) hepatectomy (Group C). Prognosis and patterns of recurrence were assessed in the 3 groups.
Results

The 3-year overall survival (OS) and disease-free survival (DFS) rates were 89.1% and 64.2% in Group A, 67.7% and 52.2% in Group B, and 86.0% and 60.1% in Group C, respectively. The OS and DFS of Group A and Group C patients surpassed those of Group B patients (Group A vs. B, P = 0.009 and P = 0.038; and Group C vs. B, P = 0.002 and P = 0.010). Patients in Groups A and C experienced significantly fewer early recurrences than did patients in Group B (P = 0.002). Furthermore, patients in Groups A and C experienced substantially fewer intrahepatic marginal (P = 0.048) and diffuse recurrences (P =0.018), and extrahepatic metastases (P=0.038) than did patients in Group B. No patient developed radiation-induced liver disease.
Conclusions

Postoperative IMRT following narrow-margin hepatectomy may be a favorable therapy for both its safety profile and clinical benefit in patients with HCC located close to the major vessels.

This article is protected by copyright. All rights reserved.

StephenW

原来的文章
生存利益与IMRT继窄缘切除术的肝癌患者靠近大血管

    威虎旺1，†，志旺1，†，建雄WU2，†，陶Zhang1，伟奇戎，李明Wang2，景进1，舒莲旺1，甬温松1，岳平Liu1，华REN1，辉芳1，文庆旺1，辛樊Liu1，子皓宇1 andYe熊丽1，*

DOI：10.1111 / liv.12857

这篇文章是受版权保护的。版权所有。

问题
封面图片卷。 35第5期
肝国际

接受第（接受，未编辑的文章，并在网上公布可引用的最终编辑和记录的排版本将出现在未来。）

    1部放射肿瘤学，肿瘤医院和研究所，中国医学科学院的
    2腹部外科，肿瘤医院和研究所，中国医学科学院（CAMS）和中国协和医科大学（北京协和医学院）

    †作者分享共同第一作者

*通讯作者：叶凶厉，MD，放疗科，肿瘤医院和研究所，中国医学科学院（CAMS）和中国协和医科大学（北京协和医学院），北京100021，中国公关系。联系电话：（+ 86）10-87788860;传真：（+ 86）10-67706153;电子信箱：[email protected]

    这篇文章已被接受发表，并经过充分的同行评审，但经过审稿，排版，分页和校对过程中，这可能会导致这个版本和记录的版本之间的差异一直没有。请引用这篇文章的DOI：10.1111 / liv.12857
   

抽象
目的

调查术后调强放疗（IMRT）在接受窄利润率为肝切除靠近大血管肝细胞癌（HCC）患者中的作用。
方法

这一探索性研究涉及181肝癌患者。其中，116均采用窄缘（<1.0厘米）切除。三十三的116例行术后调强放疗（A组），而83没有接受放疗（B组）。其余65例患者行宽缘（≥1.0厘米）切除（C组）。预后和复发的模式进行了评估，在3组。
结果

3年总生存期（OS）和无病生存率（DFS）分别为C组89.1％，而在A组64.2％，67.7％和B组52.2％，和86.0％和60.1％，分别为。操作系统DFS A组和C组患者和超过B组患者（A组对B，P = 0.009和P = 0.038; C组与B，P = 0.002，P = 0.010）。在A组和C患者出现显著减少复发的早期B组（P = 0.002），比没有病人​​。此外，患者A组和C经历了大幅减少肝内边际（P = 0.048）和复发弥漫（P = 0.018），与肝外转移（P = 0.038），B组比没有的患者无一例辐射引起的肝脏疾病。
结论

术后IMRT下窄缘切除可能是一个有利的治疗肝癌患者靠近大血管无论其安全性和临床获益。

这篇文章是受版权保护的。版权所有。

挚友888888

Thanks!!!

果农

楼主的韩语真好，
可惜看不懂