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肝胆相照论坛 论坛 学术讨论& HBV English Jensen用Ichor的DNA给药技术在乙肝疫苗
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Jensen用Ichor的DNA给药技术在乙肝疫苗 [复制链接]

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发表于 2015-4-14 09:54 |只看该作者 |倒序浏览 |打印
Janssen to use Ichor's DNA drug delivery technology in hep B vaccines
Apr 13 2015, 09:28 ET | By: Douglas W. House, SA News Editor [Contact this editor with comments or a news tip]

    Privately-held Ichor Medical Systems and Janssen Pharmaceuticals (NYSE:JNJ) enter into a product development collaboration and worldwide license agreement to develop and commercialize DNA-based vaccine products for the treatment of chronic hepatitis B infection utilizing Ichor's drug administration-boosting TriGrid electroporation technology.
    Electroporation is a molecular biology technique in which an electrical field is applied to cells in order to increase the permeability of the cell membranes thereby facilitating the introduction of drugs into the cells.
    Ichor's TriGrid Delivery System increases DNA drug delivery up to 1,000x compared to conventional injection.
    Under the terms of the agreement, Ichor will receive an upfront payment, R&D support and development and sales milestones of up to $85M in addition to royalties on commercial sales of licensed products. Janssen will assume responsibility for certain development costs and all commercial costs associated with the partnership, including manufacturing and distribution expenses for TriGrid.

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发表于 2015-4-14 09:57 |只看该作者
Jensen用Ichor的DNA给药技术在乙肝疫苗
2015年4月13日,09:28 ET |按:道格拉斯W.房子,SA新闻编辑[联系这个编辑器评论或新闻提示]

    私人持有的Ichor医疗系统和扬森制药公司(NYSE:JNJ)进入产品开发协作和全球许可协议,以开发和商业化DNA为基础的疫苗产品用于治疗慢性乙肝感染利用Ichor的药品监督管理,促进TriGrid电穿孔技术的处理。
    电穿孔是其中电场被施加到细胞,以增加细胞膜从而便于引入药物进入细胞的渗透性的分子生物学技术。
    Ichor的TriGrid交付系统增加了DNA的药物输送高达1,000倍相对于传统的注射。
    根据协议的条款,腐液将收到预付款,R&D的支持和发展,高达$ 8500,除了销售里程碑,特许权使用费的特许产品的商业销售。扬森将承担一定的开发成本,并与合作伙伴关系,其中包括制造及分销费用TriGrid相关的所有商业费用的责任

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发表于 2015-4-14 22:30 |只看该作者
谢谢分享。
病友交流,仅供参考.

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发表于 2015-4-15 07:19 |只看该作者
只有强大的利益驱使,才能加快药物研究的脚步。
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