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RS-3641
Viral hepatitis
Hepatitis B & D - Experimental
THE IMPACTS OF BASELINE CLINICAL CHARACTERISTICS AND HEPATITIS B VIRUS MUTATIONS ON CURATIVE EFFECTS OF CHRONIC HEPATITIS B TREATED WITH NOVAFERON
Wu Daxian1, Tan Deming* 1
1Department of Infectious Diseases, Xiangya Hospitalo of Central South University, Changsha, China
Corresponding author’s email: [email protected]
Background and Aims: Background and aims: Novaferon,which is a new type of IFN, had approved by State Food and Drug Administration (SFDA) for clinical trials of new drugs on CHB therapy in 2009.To assess the impacts of baseline clinical characteristics of patients with chronic hepatitis B (CHB) and baseline hepatitis B virus (HBV) gene mutations on curative effects of CHB treated with Novaferon.
Methods: Methods Enrolled patients accepted Novaferon monotherapy for 24 weeks and follow up for 12 weeks. Body mass index （BMI） of patients ，genotype ，basal core promoter (BCP) and precore (PC) , reverse transcriptase(RT), S region variants of HBV were determined prior to Novaferon treatment . Aminotransferase (ALT), Hepatitis B e antigen (HBeAg), HBV DNA, Hepatitis B surface antigen (HBsAg) were determined at the beginning of treatment and 12 weeks after treatment. Then the present study evaluated the influence of age , gender, genotype , BMI, baseline ALT, HBeAg, HBV-DNA, HBsAg titer as well as BCP，PC，RT and S region variants on curative effects of chronic hepatitis B treated with Novaferon。
Results: Results In total of 126 CHB patients who finished the treatedment and follow-up, 38.9% obtained virological response and 32.5%, 25.4%, 44.4%, 23.8% obtained HBeAg clearence, HBeAg seroconversion, biochemical response and combined response respectively. The baseline DNA level of virological response group was significantly lower than no-virological response group; the baseline ALT level were significantly higher in HBeAg clearence group and HBeAg seroconversion group; female and lower BMI level was prone to acquired biochemical response. Stepwise logistic regression analysis showed that PC-P159T(ntC2288A), BCP-N118T（ntA1726C）, BCP-L134L (ntA1775C/G/T） were independent influence factors for virological response. The frequencies of PC-G182C (ntG2357T) was significantly higher in groups with HBeAg clearance group and PC-S64A/T(ntT2003G/A), PC-W28STOP (ntG1896A) was significantly higher in HBeAg seroconversion groups , combined response respectively.
Conclusions: Conclusions Novaferon was an effective therapeutic drug for CHB patients, different response type was influenced by different clinical characteristics and mutations. Baseline mutations screening could predict curative effect of Novaferon efficiently and offered the optimal drugs for CHB patients.
Disclosure of Interest: None Declared
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发表于 2015-4-6 21:11
