15/10/02说明:此前论坛服务器频繁出错,现已更换服务器。今后论坛继续数据库备份,不备份上传附件。

肝胆相照论坛

 

 

肝胆相照论坛 论坛 学术讨论& HBV English TEKMIRA制药股份有限公司FILES(8-K)披露进入到材料 ...
查看: 1326|回复: 9
go

TEKMIRA制药股份有限公司FILES(8-K)披露进入到材料 [复制链接]

Rank: 10Rank: 10Rank: 10

现金
20420 元 
精华
帖子
12768 
注册时间
2013-12-29 
最后登录
2024-5-19 
1
发表于 2015-3-19 10:56 |只看该作者 |倒序浏览 |打印
TEKMIRA PHARMACEUTICALS CORP FILES (8-K) Disclosing Entry into a Material Definitive Agreement, Completion of Acquisition or Disposition of Assets, Unregistered Sale of Equity Securities, Material Modification to Rights of Security Holders, Change in Dire

By Edgar Glimpses         March 4, 2015 5:03PM        Share:
Item 1.01. Entry into a Material Definitive Agreement.
The information set forth in Item 2.01 below in this Current Report is incorporated by reference herein in response to this Item 1.01. At the Effective Time of the Merger, Tekmira Pharmaceuticals Corporation, a British Columbia corporation ("Tekmira"), through its wholly-owned subsidiary OnCore Biopharma, Inc., a Delaware corporation ("OnCore"), became a party to two material agreements: (i) an exclusive, worldwide, sublicensable (subject to certain restrictions with respect to licensed viral infections other than hepatitis) license with Cytos Biotechnology Ltd. ("Cytos") to six different series of compounds (the "Cytos License") and (ii) a license agreement with NeuroVive Pharmaceutical AB ("NeroVive") regarding oral dosage form sanglifehrin based cyclophilin inhibitors (the "NeuroVive License").
The licensed compounds from the Cytos License are Qbeta-derived virus-like particles that encapsulate TLR9, TLR7 or RIG-I agonists and may or may not be conjugated with antigens from hepatitis virus or other licensed viruses. We will have an option to expand this license to include additional viral infections other than influenza and Cytos will retain all rights for influenza, all non-viral infections, and all viral infections (other than hepatitis) for which we do not exercise our option. In partial consideration for this license, we, through OnCore, will be obligated to pay up to a total of $67 million for each of the six licensed compound series upon the achievement of specified development and regulatory milestones for hepatitis and each additional licensed viral infection, up to a total of $110 million upon the achievement of specified sales performance milestones, and tiered royalty payments in the high-single to low-double digits, based upon net sales of licensed products.
The NeuroVive License grants us, through OnCore, an exclusive, worldwide, sublicensable license to develop, manufacture and commercialize, for the treatment of HBV, oral dosage form sanglifehrin based cyclophilin inhibitors (including OCB-030). Under the NeuroVive License, we, through Oncore, will have a non-exclusive, royalty free right and license and right of reference to NeuroVive's relevant regulatory approvals and filings for the sole purpose of developing, manufacturing and commercializing licensed products for the treatment of HBV. Under the NeuroVive License, we have (1) an option to expand the exclusive license to include treatment of viral diseases other than HBV and (2) an option, exercisable upon specified conditions, to expand our exclusive license to include development, manufacture and commercialization of non-oral variations of licensed products for treatment of viral diseases other than HBV. NeuroVive retains all rights with respect to development, manufacture and commercialization of licensed products and non-oral variations of licensed products for all indications (other than HBV) for which we have not exercised the option.
Item 2.01. Completion of Acquisition or Disposition of Assets.
On March 3, 2015, the shareholders of Tekmira, approved and adopted an Agreement and Plan of Merger and Reorganization (the "Merger Agreement") by and among Tekmira, TKM Acquisition Corporation, a Delaware corporation and a wholly-owned subsidiary of Tekmira ("Merger Subsidiary"), and OnCore, pursuant to which Merger Subsidiary merged with and into OnCore, with OnCore surviving as a wholly-owned subsidiary of Tekmira (the "Merger"). The closing of the Merger occurred on March 4, 2015 and the Merger became effective with the filing of a Certificate of Merger with the Secretary of State of the State of Delaware on March 4, 2015 (the "Effective Time").
--------------------------------------------------------------------------------
At the Effective Time, each issued and outstanding share of OnCore common stock was converted into and represents the right to receive 23,973,315 common shares of Tekmira. At the Effective Time, each OnCore stock option, whether vested or unvested (the "Option Awards"), outstanding immediately prior to the Effective Time was assumed by Tekmira and converted automatically at the Effective Time into an option denominated in Tekmira common shares. The Option Awards shall continue to be subject to substantially the same terms and conditions as were applicable to the Option Awards in effect immediately prior to the Effect Time, other than for the adjustments described in the Merger Agreement. At the Effective Time, each OnCore restricted stock award (the "Stock Awards") that was outstanding immediately prior to the Effective Time was assumed by Tekmira and converted automatically at the Effective Time into a restricted stock award denominated in Tekmira common shares. The Stock Awards shall continue to be subject to substantially the same terms and conditions as were applicable to the Stock Awards in effect immediately prior to the Effective Time, other than for the adjustments described in the Merger Agreement.
Immediately following completion of the Merger, Tekmira security holders owned 50\% of the outstanding equity of the combined company, and OnCore security holders owned 50\% of the outstanding equity of the combined company, calculated immediately prior to the Effective Time on a fully-diluted and as-converted basis using the "treasury stock method". However, immediately following completion of the Merger, Tekmira and OnCore security holders owned approximately 48.5\% and 51.5\%, respectively, of the issued and outstanding common shares of Tekmira, calculated on a non-diluted basis.
Item 3.02. Unregistered Sales of Equity Securities
The information set forth in Item 2.01 above in this Current Report is incorporated by reference herein in response to this Item 3.02. In connection with the Merger, Tekmira issued an aggregate of 23,973,315 common shares to the former securityholders of OnCore, all of which were unregistered. The Tekmira common shares issued in connection with the Merger were issued pursuant to an exemption from the registration requirements under Section 5 of the Securities Act of 1933 provided by Section 4(a)(2) thereof and Rule 506(b) of Regulation D thereunder.
Item 3.03. Material Modification to Rights of Security Holders.
The information set forth in Item 2.01 above in this Current Report is incorporated by reference herein in response to this Item 3.03.
Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
Pursuant to the Merger Agreement, at the Effective Time, the number of authorized directors of Tekmira was amended to be seven directors, with the following individuals appointed to serve on the board of directors until their successors are elected: Vivek Ramaswamy, Mark Murray, Frank Karbe, Keith Manchester, William Symonds, Richard Henriques and Herbert Conrad. Mr. Ramaswamy will serve as Chairman of the Board
Item 5.03. Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year.
Pursuant to the Merger Agreement, at the Effective Time, the Articles of the Company, as in effect immediately prior to the Effective Time, were amended to provide for certain governance matters after the closing of the Merger. A copy of this Amendment to the Articles of the Company is attached hereto as Exhibit 3.1 and incorporated herein by reference in its entirety.
--------------------------------------------------------------------------------
Item 5.07. Submission of Matters to a Vote of Security Holders.
A special meeting of the Company's shareholders was held on March 3, 2015, at which the Company's shareholders:
1) Approved (a) an Agreement and Plan of Merger, dated January 11, 2015 (the "Merger Agreement"), by and among Tekmira, TKM Acquisition Corporation, a wholly-owned subsidiary of Tekmira, and OnCore Biopharma, Inc., and (b) the issuance of common shares of Tekmira pursuant to the terms of the Merger Agreement.
Votes For \% For Votes \% Against Abstentions Broker
Against Non-Votes
11,442,301 99.47\% 61,127 0.53\% 0 0
2) Approved an amendment to Tekmira's Articles to provide for certain governance matters after the closing of the merger.
Votes For \% For Votes \% Against Abstentions Broker
Against Non-Votes
11,427,064 99.34\% 76,364 0.66\% 0 0
Item 7.01. Regulation FD Disclosure
On March 3, 2015, Tekmira issued a press release announcing the results of the shareholder's vote. A copy of the press release is attached hereto as Exhibit 99.1 and incorporated herein by reference in its entirety.
The information in this Item 7.01, including Exhibit 99.1 and the information contained therein, is being furnished to the SEC but shall not be deemed to be "filed" for the purposes of Section 18 of the Exchange Act, or otherwise subject to the liabilities of that section, and shall not be incorporated by reference to any filings under the Exchange Act or the Securities Act, excerpt as specifically set forth in such statement or report.
Item 9.01. Financial Statements and Exhibits.
(a) Financial Statements of business acquired.
Not applicable (b) Pro forma financial information. Not applicable (c) Shell company transactions. Not applicable (d) Exhibits Exhibit No. Description 3.1 Amendment to the Articles of Tekmira Pharmaceuticals Corporation, dated March 4, 2014 99.1 Press Release, dated March 3, 2015
- See more at: http://www.equities.com/index.ph ... thash.gUKO2N6u.dpuf

Rank: 10Rank: 10Rank: 10

现金
20420 元 
精华
帖子
12768 
注册时间
2013-12-29 
最后登录
2024-5-19 
2
发表于 2015-3-19 10:57 |只看该作者
TEKMIRA制药股份有限公司FILES(8-K)披露进入到材料最终协议,收购或处置资产,权益性证券的未注册销售,材料改性,以完成证券持有人的权利,改变在Dire

埃德加一瞥2015年3月4日下午5时03分分享:
项目1.01。进入物料最终协议。
所列项目2.01以下在此当前报告中的信息通过引用并入本文以响应此项目1.01。在合并生效时,Tekmira制药公司,英国哥伦比亚公司(“Tekmira”),通过其全资子公司OnCore生物制药公司,美国特拉华州公司(“OnCore”),成为党的两个重大协议:(一​​)一个排他性的,全球性,转授权(需相对于一定的限制持牌病毒感染肝炎比其他)执照Cytos生物科技有限公司(“Cytos”),以六个不同系列化合物(以下简称“Cytos许可证”)和(ii)与NeuroVive药业AB(“NeroVive”)关于口服剂型sanglifehrin基于亲环蛋白抑制剂(以下简称“NeuroVive许可证”)的许可协议。
从Cytos许可证许可的化合物是Qbeta衍生的病毒样颗粒封装TLR9,TLR7或RIG-I激动剂,并且可以或可以不与来自肝炎病毒或其他授权的病毒抗原缀合。我们将有一个选项,以扩大该授权包括其他病毒感染比流感及其他Cytos将保留对流感的所有权利,所有的非病毒感染,所有病毒感染(肝炎相比除外),我们不行使我们的选择。在此许可证的部分考虑,我们通过OnCore,将有义务在实现特定的发展和监管的里程碑付出最多,共6700万美元为每6个持牌复合一系列的肝炎和每增加一个许可的病毒感染,最多,共1.1亿美元后,实现指定的销售业绩的里程碑,并分层版权费的高单低双位数,基于净销售额授权产品。
该NeuroVive许可证授予我们,通过OnCore,独家,全球,再授权许可,用以开发,生产和销售,为乙肝病毒的治疗,口服剂型sanglifehrin基于亲环蛋白抑制剂(包括OCB-030)。根据NeuroVive许可,我们通过Oncore,将有一个非排他性的,免版税的权利和许可,并参考权NeuroVive的相关监管部门的批准和备案的开发,生产和商业化许可产品乙肝治疗的唯一目的。根据NeuroVive许可证,我们有(1)选项以扩大独占许可,包括治疗乙肝相比,(2)选项病毒性疾病等的,在行使规定的条件,以扩大我们的独家授权,包括开发,制造和商业化用于治疗病毒性疾病比HBV等特许产品的非口服变化。 NeuroVive保留就开发,制造和授权的产品和所有的迹象表明(除HBV除外),我们还没有行使期权授权产品的非口服变化商品化的所有权利。
项目2.01。完成收购或资产处置。
于2015年3月3日,Tekmira的股东批准,并经与中Tekmira,TKM收购公司,一家特拉华州公司和Tekmira的全资子公司(通过兼并重组(下称“合并协议”)的协议,并计划“合并子公司”),并OnCore,据此,合并子公司合并进入OnCore,与OnCore生存为Tekmira(以下简称“合并”)的全资子公司。在合并完成发生在2015年3月4日及合并生效与合并的证书与特拉华州州务卿提交的2015年3月4日(“生效时间”)。
-------------------------------------------------- ------------------------------
在有效的时间中,OnCore普通股已发行及发行在外的股份被转换成,并表示接受Tekmira的23973315普通股的权利。在有效的时间,每个OnCore股票期权,无论是霸气还是未定(以下简称“方案奖”),优秀紧接的有效时间是承担Tekmira,并自动在有效的时间转化为计价Tekmira普通股的期权。该期权奖励将继续受到大致相同的条款和条件,都适用于该期权奖励的效​​果比合并协议中所述的调整前夕的影响时间,等。在有效的时间,每个OnCore限制性股票奖励(以下简称“股票奖励”),有效时间为承担Tekmira并自动转换为有效时间为一个限制性股票奖励计价Tekmira普通股前夕表现非常出色。股票奖励将继续受到大致相同的条款和条件,实际上是适用于股票奖前夕的有效时间,比其他的合并协议中所述的调整。
紧随合并完成后,Tekmira证券持有人所拥有合并后公司的发行在外的股份的50 \%,而OnCore证券持有人所拥有合并后公司的发行在外的股份的50 \%,计算前夕的有效时间上完全使用“库藏股法”-diluted并作为转换的基础。 Tekmira的已发行及发行在外的普通股,计算出在非稀释的基础上。然而,紧随合并完成之后,Tekmira和OnCore证券持有人持有约48.5 \%和51.5 \%,分别。
项目3.02。未注册的销售权益性证券
所列项目2.01以上在此当前报告中的信息通过引用并入本文以响应此项目3.02。与合并连接,Tekmira发行23973315股普通股,总要OnCore前证券持有人,所有这些都是未经注册的。与合并而发行的Tekmira普通股根据1933年证券法由第4条第5条根据发行从注册要求的豁免(一)(二)和其506条(二)D条例项下的。
项目3.03。重大修改证券持有人的权利。
所列项目2.01以上在此当前报告中的信息通过引用并入本文以响应此项目3.03。
项目5.02。董事或某些官员离境;选举董事;委任某些官员;某些官员的补偿安排。
根据合并协议,在有效的时间,Tekmira授权董事人数被修正为七名董事,与以下人员任命为董事会成员,直到选出继任者:维韦克拉马斯瓦米,马克·穆雷,弗兰克Karbe,基思·曼彻斯特,威廉·西蒙兹,理查德·恩里克斯和赫伯特·康拉德。拉马斯瓦米先生将担任董事会主席
项目5.03。修订公司章程或章程;更改会计年度。
根据合并协议,在有效的时间,公司章程的公司,如立即生效前的有效时间,进行了修正,规定在合并完成后,某些管理事务。连接该修订本公司章程的复印件附上作为证据3.1和其全文引用作为参考。
-------------------------------------------------- ------------------------------
项目5.07。事项提交给证券持有人的投票。
本公司股东特别会议举行了2015年3月3日,在该公司的股东:
1)批准(一)的协议和合并计划,日期为2015年1月11日(以下简称“合并协议”),通过与中Tekmira,TKM收购公司,Tekmira的全资子公司,并OnCore生物制药公司, (二)发行Tekmira的根据合并协议的条款的普通股。
票\%选票\%反对弃权经纪人
对非投票
11442301 99.47 \%61127 0.53 \%0 0
2)批准一项修正案,Tekmira的文章提供了合并完成后,某些管理事务。
票\%选票\%反对弃权经纪人
对非投票
11427064 99.34 \%76364 0.66 \%0 0
项目7.01。监管FD披露
于2015年3月3日,Tekmira发布新闻稿宣布的股东投票结果。新闻稿的副本兹附上图表99.1,并在其全部引入作为参考。
在这个项目7.01,其中包括展览99.1和其中包含的信息的信息,被提供给美国证券交易委员会,但不应被视为是“申请”为交易法第18条的目的,或以其他方式受到的法律责任那款,不得参照下交易法或证券法的任何申请被纳入,摘录特别阐明在这样的陈述或报告。
项目9.01。财务报表和展品。
(一)收购企业的财务报表。
不适用(二)备考财务资料。不适用(三)壳牌公司的交易。不适用(四)参展展品编号说明3.1修订Tekmira制药公司的有关规定,日期2014年3月4日99.1新闻稿,日期为2015年3月3日
- 查看更多在:http://www.equities.com/index.ph ... thash.gUKO2N6u.dpuf

Rank: 10Rank: 10Rank: 10

现金
20420 元 
精华
帖子
12768 
注册时间
2013-12-29 
最后登录
2024-5-19 
3
发表于 2015-3-19 10:57 |只看该作者
本帖最后由 newchinabok 于 2015-3-19 10:58 编辑

http://www.cytos.com/press-releases/        Cytos生物科技有限公司

Rank: 6Rank: 6

现金
1290 元 
精华
帖子
1070 
注册时间
2015-1-11 
最后登录
2015-8-9 
4
发表于 2015-3-19 12:28 |只看该作者
回复 newchinabok 的帖子

这公司有个治疗哮喘的药、拿来治乙肝了、你怎么看

Rank: 6Rank: 6

现金
1290 元 
精华
帖子
1070 
注册时间
2015-1-11 
最后登录
2015-8-9 
5
发表于 2015-3-19 19:40 |只看该作者
本帖最后由 战天斗hbv 于 2015-3-19 19:41 编辑

而且我印象中,这个公司就是被这个哮喘药,搞破产的,临床实验效果不好,前面的新药帖子我提到过

Rank: 7Rank: 7Rank: 7

现金
3378 元 
精华
帖子
2638 
注册时间
2007-4-5 
最后登录
2022-11-8 
6
发表于 2015-3-19 20:15 |只看该作者
回复 战天斗hbv 的帖子

有意思。
病友交流,仅供参考.

Rank: 6Rank: 6

现金
1290 元 
精华
帖子
1070 
注册时间
2015-1-11 
最后登录
2015-8-9 
7
发表于 2015-3-19 20:30 |只看该作者
本帖最后由 战天斗hbv 于 2015-3-19 20:33 编辑

我说的肯定没错、这个公司是把治哮喘失败了的药物拿来治hbv了、手机翻以前的帖子不方便、但是肯定有这么回事。召唤sw

Rank: 6Rank: 6

现金
1290 元 
精华
帖子
1070 
注册时间
2015-1-11 
最后登录
2015-8-9 
8
发表于 2015-3-19 20:39 |只看该作者
想起来了、这药叫cyt003、把公司搞破产的药物、汗

Rank: 8Rank: 8

现金
62111 元 
精华
26 
帖子
30441 
注册时间
2009-10-5 
最后登录
2022-12-28 

才高八斗

9
发表于 2015-3-19 20:41 |只看该作者
回复 战天斗hbv 的帖子

"这个公司是把治哮喘失败了的药物拿来治hbv了" - 是不正确的.

CYTOS授权他们的一个技术给Oncore. 该技术被称为VLP Virus Like Particle,(病毒样颗粒).最有可能这可以用于开发HBV的治疗性疫苗.

Rank: 6Rank: 6

现金
1290 元 
精华
帖子
1070 
注册时间
2015-1-11 
最后登录
2015-8-9 
10
发表于 2015-3-19 20:44 |只看该作者
本帖最后由 战天斗hbv 于 2015-3-19 20:53 编辑

回复 StephenW 的帖子

哦~~~谢谢!您怎么看这个VLP技术?这个技术靠谱的话,公司怎么会败在一个哮喘药物上。。。。
‹ 上一主题|下一主题
你需要登录后才可以回帖 登录 | 注册

肝胆相照论坛

GMT+8, 2024-5-19 18:37 , Processed in 0.015334 second(s), 11 queries , Gzip On.

Powered by Discuz! X1.5

© 2001-2010 Comsenz Inc.