瞬时弹性成像的评估慢性病毒性肝炎肝纤维化的准确度：采

StephenW

Accuracy of transient elastography in assessing liver fibrosis in chronic viral hepatitis: A multicenter, retrospective study

    Yeon Seok Seo1,†,
    Moon Young Kim2,†,
    Seung Up Kim3,*,
    Bae Si Hyun4,
    Jae Young Jang5,
    Jin Woo Lee6,
    Jung Il Lee3,
    Sang Jun Suh7,
    Soo Young Park8,
    Hana Park9,
    Eun Uk Jung10,
    Byung Seok Kim11,
    In Hee Kim12,
    Tae Hee Lee13,
    Soon Ho Um1,
    Kwang-Hyub Han3,
    Sang Gyune Kim14,
    Soon Koo Paik3,
    Jong Young Choi4,
    Soung Won Jeong5,
    Young Joo Jin6,
    Kwan Sik Lee3,
    Hyung Joon Yim7,
    Won Young Tak8,
    Seong Gyu Hwang9,
    Youn Jae Lee10,
    Chang Hyeong Lee11,
    Dae Chon Kim12,
    Young Woo Kang13,
    Young Seok Kim14,* and
    The Korean Transient Elastography Study Group

DOI: 10.1111/liv.12808

Abstract
Background/aims

Transient elastography (TE) has become an alternative to liver biopsy (LB). This study investigated the diagnostic performance of liver stiffness (LS) measurement using TE in Korean patients with chronic hepatitis B and C (CHB and CHC).
Methods

From April 2006 to June 2014, 916 patients (567 CHB and 349 CHC) who underwent LB and TE at 15 centers were analyzed. The Batts and Ludwig scoring system was used for histologic assessment. Aspartate aminotransferase (AST)–to–platelet ratio indexes (APRI) were calculated. Area under the receiver operating characteristic curve (AUROC) was used.
Results

The median age, LS value, and APRI score were 45 years, 8.8 kPa, and 0.61, respectively, in CHB patients versus 51 years, 6.8 kPa and 0.55, respectively in CHC patients. TE was significantly superior to APRI in CHB patients (AUROC 0.774 vs. 0.72 for ≥F2, 0.849 vs. 0.812 for ≥F3, and 0.902 vs. 0.707 for F4, respectively; all P<0.05). Furthermore, TE was significantly superior for predicting ≥ F3 stage (AUROC 0.865 vs. 0.840, P=0.009) whereas it was similar for predicting ≥ F2 and F4 stage (AUROC 0.822 vs. 0.796; 0.910 vs. 0.884; all P>0.05) in CHC patients. In CHB patients, optimal cutoff LS values were 7.8 kPa for ≥ F2, 8.2 kPa for ≥ F3, and 11.6 kPa for F4, versus 6.8 kPa, 8.6 kPa, and 14.5 kPa, respectively, in CHC patients.
Conclusions

TE can accurately assess the degree of liver fibrosis in Korean patients with CVH. TE was superior to APRI for predicting each fibrosis stage.

This article is protected by copyright. All rights reserved.

StephenW

瞬时弹性成像的评估慢性病毒性肝炎肝纤维化的准确度：采用多中心，回顾性研究

    妍锡SEO1，†，
    月亮年轻Kim2，†，
    升向上Kim3，*，
    裴思Hyun4，
    在荣Jang5，
    金佑Lee6，
    郑日Lee3，
    桑俊Suh7，
    洙年轻Park8，
    花PARK9，
    恩屋Jung10，
    炳锡Kim11，
    在熙Kim12，
    金泰熙Lee13，
    不久何UM1，
    刘广Hyub Han3，
    桑Gyune Kim14，
    不久辜Paik3，
    钟扬Choi4，
    Soung韩元Jeong5，
    杨裕Jin6，
    关锡Lee3，
    亨俊Yim7，
    韩元年轻Tak8，
    洪城揆Hwang9，
    妍宰Lee10，
    张馨Lee11，
    金大中川川Kim12，
    杨禹Kang13，
    年轻锡Kim14，*和
    韩国瞬时弹性成像研究组

DOI：10.1111 / liv.12808

抽象
背景/目标

瞬时弹性（TE）已经成为一种替代肝活检（LB）。这项研究调查了韩国慢性乙型和丙型肝炎（CHB和CHC）采用TE肝脏硬度（LS）测量的诊断性能。
方法：

从2006年4月至2014年6月，916例（567 CHB和349 CHC）谁接受LB和TE在15个中心进行了分析。絮层和路德维希评分系统被用于组织学评估。谷草转氨酶（AST）-to-血小板比率指数（APRI）进行了计算。受试者工作特征曲线（AUROC）下的面积，使用。
结果

年龄中位数，LS值，APRI得分分别为45年来，8.8千帕，和0.61，分别在CHB患者与51年，6.8千帕和0.55，分别在CHC患者。 TE是显著优于APRI慢性乙型肝炎患者（对于≥F2，0.849与0.812 AUROC 0.774与0.72≥F3和0.902 0.707对比为F4，分别; P均<0.05）。此外，TE是显著优于预测≥F3阶段（AUROC 0.865与0.840，P = 0.009），而这是类似的预测≥F2和F4级（AUROC 0.822与0.796; 0.910与0.884;均P> 0.05）在CHC患者。慢性乙型肝炎患者，最佳截断LS值分别为7.8千帕为≥F2，8.2千帕为≥F3和11.6千帕为F4中，相对于6.8千帕，8.6千帕，和14.5千帕，分别在CHC患者。
结论

TE可以准确评估肝脏纤维化程度的韩国患者的CVH。 TE优于APRI预测每个纤维化阶段。