研究人员发现年龄和抗HBV之间的联系

StephenW

Researchers find link between age, HBV resistance
By Stacy Hsu  /  Staff reporter

Age may be a factor in battling the hepatitis B virus (HBV), researchers from National Taiwan University’s College of Medicine said yesterday.

Why a majority of adults infected with the virus are able to fight off the virus, while most infected newborns and toddlers end up developing a chronic hepatitis B infection has long baffled doctors and scientists.

Graduate Institute of Clinical Medicine associate professor Wang Hurng-yi (王弘毅), one of the authors of the research, said nearly 95 percent of adult-acquired hepatitis B infections lead to spontaneous clearance, while more than 90 percent of infected newborns and about 30 percent of infected children aged between one and five years old are unable to fight off the virus and subsequently develop a chronic infection.

“These statistics suggest that a person’s immune clearance of hepatitis B — which has affected nearly 2 billion people worldwide — is heavily age-related. However, as the reason for this remains unknown, our research team has made it its mission to find an answer,” Wang told a press conference in Taipei.

As a baby’s postnatal gut microbiota is not established until a toddler is two or three years old, the researchers presumed that gut commensals might be mainly responsible for preparing the liver’s immune system to fight the hepatitis B virus.

To prove this hypothesis, the researchers injected the virus into mice that ranged from from six-to-12 weeks old. They discovered that adult mice were able to clear the hepatitis B virus within six weeks after the injection, while their young remained hepatitis B virus-positive even after 26 weeks.

“We laced the drinking water of mice aged between five weeks and 12 weeks old with an antibiotic to have them gut-sterilized, resulting in a noticeable reduction in the level of gut bacteria DNA in stools,” Wang said.

Although the amount of stool bacteria in mice given antibiotics returned to normal shortly after antibiotic treatment ended, they were unable to clear the hepatitis B virus after they matured, Wang said.

The researchers also found that mice with the toll-like 4 receptor (TLR4) mutation were able to fight off the hepatitis B virus regardless of their age, offering a potential new treatment for neonates infected with hepatitis B at birth.

Chen Ding-shinn (陳定信), a hepatitis specialist and former head of the university’s College of Medicine, said more than half of the hepatitis B carriers in Taiwan caught the virus from their infected mothers during delivery.

“The link discovered between TLR4 deficiency in mice and the ability to clear HBV could be a giant step forward in finding ways to break the cycle of mother-to-newborn infection,” Chen said.

The research was published in the online version of the US journal Proceedings of the National Academy of Sciences on Monday.

StephenW

研究人员发现年龄抗HBV之间的联系

年龄可能是在对抗乙肝病毒（HBV）的一个因素，研究人员从医学的国立台湾大学学院昨天说。

为什么大部分感染病毒的成年人都能够抵抗病毒，而大多数被感染的新生儿和幼儿最终发展慢性乙肝病毒感染长期以来困惑的医生和科学家。

临床医学副教授王Hurng义（王弘毅），该研究的作者之一研究所表示，近95％的成人获得性乙肝感染导致自发清除，而超过90％的受感染的新生儿约年龄在1至5年的老之间感染的儿童中30％是无法抵御病毒，并随后发展为慢性感染。

“这些统计数据表明，乙肝的人的免疫清除 - 这已经影响到近2十亿全世界人民 - 在很大程度上与年龄有关。然而，由于这种情况的原因尚不清楚，我们的研究团队已经使得它的使命找到一个答案，“王说，在台北举行记者招待会。

由于婴儿的产后肠道菌群尚未建立，直到孩子是两三岁的时候，研究人员推测，肠道共生可能是主要负责准备肝脏的免疫系统来对抗乙肝病毒。

为了证明这一假设，研究人员注射病毒进入小鼠的范围从6到12周龄。他们发现，成年小鼠能够清除注射后6个星期内乙肝病毒，而他们年轻的仍然是乙肝病毒阳性，即使26周之后。

“我们股价五岁周和12周老用抗生素将它们肠道消毒间小鼠的饮用水，从而显着减少了肠道细菌的DNA在大便的水平，”王说。

虽然抗生素治疗结束后不久，大便细菌在给予抗生素治疗小鼠的数量恢复正常，他们无法清除乙肝病毒，他们成熟之后，王先生说。

研究人员还发现，老鼠与toll样受体4（TLR4）的突变能够争取他们的年龄过乙肝病毒不分，用于提供出生时感染乙肝新生儿的潜在新治疗方法。

陈定希恩（陈定信），肝炎专家和医学大学学院的前负责人说，超过一半在台湾乙肝携带者在分娩过程中引起了病毒从被感染的母亲。

“TLR4缺陷小鼠和清除乙肝病毒的能力之间发现的链接可能是一个巨大的进步，想尽办法打破了母亲对新生儿感染周期，”陈先生说。

这项研究发表在美国国家科学院的美国杂志诉讼周一的在线版本。

MP4

好
明显和肠道有关系

王震宇

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