乙肝加强注射可根据医学研究的OU学院是不必要的

StephenW

Hepatitis B booster shots may be unnecessary according to OU College of Medicine study

OU researchers find hepatitis B vaccinations given early in life still provide protection even in the teen years.

Posted: Thursday, July 31, 2014 4:00 pm

by Aaron Howell

An OU researcher found that infants vaccinated for hepatitis B at birth are protected throughout adolescence and may not need the recommended booster shot.

Amy Middleman, chief of adolescent medicine at OU College of Medicine, was the principal investigator in a study funded by the CDC with collaboration from colleagues in Texas.

Hepatitis B is a serious liver infection that is more likely to develop in infants and children. While there is not a cure for hepatitis B, there is a vaccine that can prevent the onset of the disease and is given to children and infants within their first year of life.

As child grows into adolescence the teen typically receives a booster shot of the vaccine because doctors would test antibody levels and find them drastically low prompting a booster shot. However, Middleman's study suggests that adolescents are, in fact, still protected.

The study focused on 420 teenagers who had all received the recommended three doses of the hepatitis B vaccine before the age of one.

Researchers tested the teens’ levels of antibodies, which are Y-shaped protein found in plasma and essential for the immune system to fight off infection, before conducting the research.

Middleton said the majority of the teens, 76 percent, showed antibody levels lower than what is thought necessary to protect against the hepatitis B infection.

Researchers then administered a challenge dose of hepatitis B to test the levels of the patients’ antibodies before and after the challenge to see if there was a change signifying the need for a booster.

“Even among the adolescents who had zero or low levels of hepatitis B antibodies, they were still capable of mounting an immune response,” Middleman said.

Middleton said that after the challenge dose, 92 percent of the teens’ antibody levels; including the 76 percent of participants who were previously not thought to be protected, exceeded the level needed for protection.

“If a patient has been fully vaccinated, they are likely fully protected,” Middleton said.

StephenW

乙肝加强注射可根据医学研究的OU学院是不必要的

OU研究人员发现在生命早期接种乙肝疫苗接种仍即便是在青少年时期提供保障。

发布时间：星期四，2014年7月31日下午4:00

由艾伦·豪厄尔

一个OU研究人员发现，婴儿在出生时接种乙肝保护整个青春期，可能并不需要推荐的加强针。

艾米中间人，青春期医学在医学OU学院院长，是由CDC与同事在得克萨斯州合作资助的一项研究的主要研究者。

B型肝炎是一种严重的肝脏感染，更容易在婴儿和儿童发展。而有不能治愈乙肝，有一种疫苗可以预防疾病的发作和给予儿童和婴儿生命的第一年之内。

随着孩子的成长到青春期的青少年通常会收到一个加强针疫苗，因为医生会检测抗体水平，并找到他们大幅低促使加强针。然而，中间人的研究表明，青少年，其实还是受保护的。

该研究主要集中在谁曾收到的所有建议的三剂乙肝疫苗1岁前420青少年。

研究人员测试了青少年的水平的抗体，这是存在于血浆和必要的免疫系统对抗感染，在进行研究之前，Y形蛋白质。

米德尔顿说，大部分青少年，76％，显示出的抗体水平比被认为是必要的，以防止乙肝病毒感染低。

研究人员随后施用乙型肝炎前和攻击后检测患者的抗体的水平的攻击剂量，以查看是否有一个变化标志着需要一个助推器。

“即使是谁了乙肝抗体的零或低的水平的青少年中，它们仍然能够产生免疫应答的”中间人所述。

米德尔顿说，挑战给药后，92％的青少年的抗体水平;包括谁以前没有想过要保护参与者的76％，超过了所需要的保护水平。

“如果病人已完全接种疫苗，他们很可能会充分保护，”米德尔顿说。