Novel Strategies to Achieve Sustained Virologic Remission

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Novel Strategies to Achieve Sustained Virologic Remission

新的战略，以实现持续病毒学缓解

http://www.medscape.com/viewarticle/829588_6

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Conclusion & Future Perspective  结论与未来展望

Conclusion & Future Perspective

Since sustained virologic remission of HBV does not occur as a result of existing treatment, novel strategies will have to be adopted. A learned approach to achieve this goal is to circumvent the various factors by which HBV establishes chronic infection in humans. Targeting a combination of viral and host factor offers the best possible chance for accomplishing this objective. Safety of a variety of these approaches, especially those targeting host immune responses have not yet been established. If these approaches are safe, they offer a unique perspective to target host immunity against HBV proteins and eventually develop protective immunity and control of HBV replication. A key viral target remains cccDNA, which requires unique approaches, which have shown in vitro effectiveness. The challenges remain on developing successful delivery system that allows every single infected cell to be subjected to disruption of ccDNA. In reality, a combination approach would be the most appropriate, effective and pragmatic technique to achieve sustained virologic remission of most CHB patients (Figure 1 & Table 1 & Table 2).

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结论与未来展望

由于乙肝病毒的持续病毒学缓解并不会出现与现有治疗的结果，新的战略将被采纳。有知识的方式达到实现这一目标是规避各种因素由慢性乙肝病毒感染人类建立。针对病毒和宿主因素的组合提供了最佳机会完成这项目标。各种综合安全方案，尤其是针对宿主的免疫反应尚未建立。如果论文的途径是安全的，他们提供了一个独特的视角来瞄准抗HBV蛋白的宿主免疫和发展保护性免疫，并最终HBV复制的控制权。一个关键的目标病毒的cccDNA仍，这需要独特的方法，从而衍生出体外效力。挑战仍然是在发展中的成功开发提供系统确实可让每一个受感染的细胞受到ccDNA中断。在现实中，组合的方法是最合适的，有效的和务实的技术来实现大部分慢性乙肝患者（图1和表1和表2）业绩持续病毒学缓解

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http://www.medscape.com/viewarticle/829588_7

点击  （Figure 1 & Table 1 & Table 2).值得一看

lgs1

能否详细解释一下?

使命123

看不懂

肝肠欲断

怎么回事？点不进去的。

StephenW

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