患有肝功能衰竭希望 - 人工肝，现在变成了现实

StephenW

                Hope for people with liver failure — artificial livers now become a reality                Editorial Team September 28, 2014 at 1:29 pm                                               
                                                        
      
      
              
                                                                                          
                                                                According to a new research, a bio-artificial liver support system for patients suffering from acute liver failure is on its way, as investigations are done to assess its safety and effectiveness. Steven D. Colquhoun, lead investigator at Cedars-Sinai said that the quest for a device that can fill in for the function of the liver (at least on a temporary basis) temporarily, has been under trial for decades. The bio-artificial liver (BAL) is the one that can achieve this task as it posses the potential to sustain patients with acute liver failure until their own livers start to self-repair.
The majority of the 49 sites currently involved in the investigation are in the United States, but studies are also underway in Europe and Australia and the research involves patients with liver disease caused by acute alcoholic hepatitis, a group with few therapeutic options. In the bio-artificial liver, which is designed by Vital Therapies Inc., blood is drawn from the patient via a central venous line, and then is filtered through a component system featuring four tubes, each about 1 foot long, which are embedded with liver cells.

The external organ support system is designed to perform critical functions of a normal liver, including protein synthesis and the processing and cleaning of a patient’s blood, after which the filtered and treated blood is returned to the patient through the central line. Colquhoun added that if successful, a bioartificial liver could not only allow time for a patient’s own damaged organ to regenerate, but also promote that regeneration and in the case of chronic liver failure, it also potentially could support some patients through the long wait for a liver transplant.
Liver disease – types, causes, symptoms, diagnosis, treatment and prevention
The liver is the largest internal organ of your body. It performs more than 500 different functions including digestion, metabolism, storing nutrients and removing toxins and waste products. Sadly, it is an easy target because everything you eat or drink is metabolised with the help of your liver. That’s one of the reasons why liver disease is now among the top lifestyle disorders or chronic diseases that are spreading like an epidemic in India.
Causes and types of liver disease
There are more than 100 different forms of liver disease caused by various factors ranging from genetic, environmental to lifestyle habits. Here are some common types of liver diseases and theri causes highlighted by Dr Adarsh CK, consultant Gastroenterologist and Hepatologist, St John’s Medical College Hospital, Banglore.
1 Alcoholic liver disease: It is caused by heavy intake of alcohol. Alcohol affects the liver cells and diverts them from their primary function of providing glucose. It can also destroy the liver cells resulting in fat deposits (alcoholic fatty liver disease) and can even cause inflammation of liver (alcoholic hepatitis). Here’s detailed information on alcohlic liver disease.
2. Non alcoholic liver disease: It is excessive fat accumulation around the liver found in people who do not consume alcohol. Here are causes, symptoms and prevention of non-alcoholic fatty liver disease.
3. Hepatitis: It is inflammation of liver, most commonly caused by hepatitis virus. There are different types of hepatitis: hepatitis A, B, C and E caused by different viruses. Read to more about diagnosis, treatment and prevention of liver disease
With inputs from ANI
Image Source: Getty Images

StephenW

希望患有肝功能衰竭 - 人工肝，现在变成了现实
编辑团队2014年9月28日在下午1时29分

肝功能衰竭根据一项新的研究，为患者从急性肝功能衰竭遭受生物人工肝支持系统是在它的途中，因为调查完成后，以评估其安全性和有效性。史蒂芬D.科洪，在雪松 - 西奈首席研究员表示，寻求能填补的肝脏功能的设备（至少是暂时的）是暂时的，一直在试用了几十年。生物人工肝（BAL）是一个可以实现此任务。它由维持治疗急性肝功能衰竭的可能，直到自己的肝脏开始自我修复。

大多数目前参与调查的49个站点都在美国，但研究也正在进行中的欧洲和澳大利亚的研究涉及患者引起的急性酒精性肝炎，一批具有一些治疗方案肝病。在生物人工肝脏，这是由生命治疗公司设计的，血液从病人经由中心静脉线拉伸，然后通过一个组件系统，具有四根管，每约1英尺长，它被嵌入与过滤肝细胞。

外部器官支持系统被设计为执行一个正常的肝脏的重要功能，包括蛋白合成，并且处理和清洗的患者的血液，在此之后，过滤，处理后的血液是通过中央线返回到患者。科洪说，如果成功的话，生物人工肝不仅可以让时间患者自身受损的器官再生，还能促进了再生和慢性肝功能衰竭的情况下，也可能会通过漫长的等待了支持某些患者肝脏移植手术。

肝病 - 类型，病因，症状，诊断，治疗和预防

肝脏是人体最大的内脏器官。它执行超过500个不同的功能，包括消化，代谢，储存的营养物质和清除毒素和废物。可悲的是，这是一个容易的目标，因为一切你吃或喝的代谢与肝脏的帮助。这就是为何肝病是目前顶级的生活方式疾病或慢性疾病的蔓延就像在印度的流行中的一个。

成因和类型肝病
有超过100种不同形式的肝脏疾病引起的各种因素，从遗传，环境到生活习惯。这里有肝病及theri原因的一些常见类型的博士阿达什讷对照，顾问胃肠病和肝病，圣约翰医学院附属医院，班加罗尔突出。

1酒精性肝病：是由酒精引起的重摄取。酒精会影响肝细胞和提供葡萄糖的主要功能转移他们。它也能破坏导致脂肪沉积的肝细胞（酒精性脂肪肝疾病），甚至可引起肝（酒精性肝炎）的炎症。下面是关于含酒精肝病的详细信息。

2，非酒精性肝病：这是人谁不饮酒发现肝脏周围过多的脂肪堆积。以下是原因，症状及预防非酒精性脂肪肝疾病。

3，肝炎：它是肝脏，最常见的由乙型肝炎病毒引起的炎症。有不同类型的肝炎：肝炎A，B，C和E由不同病毒引起。了解更多有关诊断，治疗和预防肝病

从ANI输入

图片来源：盖蒂图片社

一字

从科学角度来讲，人体的任何器官以后都存在替代的可能性。

StephenW

哈哈, 有些人的脑子要更换.

齐欢畅2

以前听说过，不是早有了吗，不过也是个好消息，算是正能量吧。意义重大，至少为患者减轻了肝脏负担。争取了时间。顶上去，让全体战友都看看。

使命123

这个好久以前就有了好像是9几年就有了对急性重症肝炎有用处

StephenW

使命123 发表于 2014-10-6 10:09
这个好久以前就有了好像是9几年就有了对急性重症肝炎有用处

                是的，这是一个新设备.
News Feature                 |   September 25, 2014        
            
   



   

    "Bio-Artificial Liver" Begins Clinical Testing   
        By Chuck Seegert, Ph.D.
           
        Testing on an engineered liver replacement is under way at Cedars-Sinai. Using human cells, the device may provide a solution to the long absent need for artificial liver function.
Patients experiencing kidney failure are able to obtain relief from dialysis treatments, a method of removing wastes from the blood. Cardiac patients can be treated with ventricular assist devices or even artificial hearts. So far, however, there has been no analog for patients undergoing liver failure.
"The quest for a device that can fill in for the function of the liver, at least temporarily, has been underway for decades,” said Steven D. Colquhoun, M.D., the surgical director of liver transplantation at Cedars-Sinai’s Comprehensive Transplant Center, in a recent press release. “A bioartificial liver, also known as a BAL, could potentially sustain patients with acute liver failure until their own livers self-repair."
The functions of the liver are very complex, which has made development of artificial liver function challenging. Normally, the liver governs regulation of glucose levels, protein production, and detoxification. Liver failure can occur for a number of reasons including trauma, viral infections, and chemical poisoning including alcohol abuse.
To mimic this function, a team at a company called Vital Therapies Inc. developed a device they call the ELAD bio-artificial liver, according to the press release. The ELAD device works by withdrawing blood from a central venous line and filtering it through a system that has four, 1-foot long tubes. Each tube contains human liver cells that process the blood, clean the blood, and make proteins — all while performing other critical organ-related processes, according to the press release.
"If successful, a bioartificial liver could not only allow time for a patient’s own damaged organ to regenerate, but also promote that regeneration. In the case of chronic liver failure, it also potentially could support some patients through the long wait for a liver transplant," Colquhoun explained in the press release.
While the technology available to replace liver function is advancing, replacement of kidney function also continues to progress. Recently, a wearable artificial kidney was approved by the FDA for human clinical trials, which are currently underway.
Image Credit: ELAD investigational bio-artificial liver support system, Vital Therapies Inc.