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吉利德许可丙型肝炎药物在印度的低成本制造商 [复制链接]

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发表于 2014-2-7 22:40 |只看该作者 |倒序浏览 |打印
Gilead to license hepatitis C drug to lower-cost manufacturers in India

February 5, 2014 5:58 PM ET



Feb 5 (Reuters) - Gilead Sciences plans to license its breakthrough hepatitis C drug Sovaldi to a number of Indian generic pharmaceutical manufacturers, allowing for lower-priced sales of the medication in that developing nation, according to the company.

Although prices for the drug have not been set, company spokesman Nick Francis said in an emailed statement on Wednesday that Gilead aims to establish "tiered pricing."

For example, the price discussed for 24 weeks of Sovaldi therapy would run about $2,500 for certain patients at public hospitals, community clinics and non-governmental agencies in India, the Hindu Business Line reported earlier this week.

"Providing treatment in resource-limited settings presents complex challenges, and we will work with partners in multiple sectors around the world to ensure our access program reaches as many patients as possible," Francis said.

Gilead said final details of the program in India will be announced in coming months. The company has a similar program in place for lower-cost versions of its HIV/AIDS drugs.

In the United States, where Sovaldi was approved by regulators in December, the drug costs $84,000 for 12 weeks of therapy or $1,000 for a daily pill.

The Foster City, California-based company has said the price is fair because the treatment offers a potential cure for the liver-destroying virus without injections of interferon, which can cause severe side effects that compromise patient outcomes.

Prices in Europe are also lower than in the United States. The cost for treatment in the United Kingdom is about $57,000 while the price in Germany is around $66,000, the company has said.

Analysts have estimated that the drug will eventually generate billions of dollars in annual sales. Sanford Bernstein has forecast sales this year alone of $6.7 billion.

But some have questioned whether that is achievable. Many patients including those in the United States, where more than half of hepatitis C patients are estimated to rely on public funding, could have difficulty securing reimbursement for such a high-priced drug.

Other companies including Johnson & Johnson, AbbVie and Merck & Co are also working to develop new hepatitis C treatments with some in advanced stages of clinical studies.

Gilead, which reported 2013 earnings on Tuesday, declined to include an estimate for hepatitis C sales in its 2014 sales forecast, saying only that Sovaldi sales so far have been strong and broadly based.

Sales of Sovaldi in the last three weeks of 2013 totaled more than $139 million.

The World Health Organization estimates that about three percent of the world's population has been infected with the hepatitis C virus and that more than 170 million chronic carriers are at risk of developing liver cirrhosis, liver cancer or both.

Shares of Gilead fell $3.87, or nearly five percent, to close at $78.15 in Nasdaq trading on Wednesday. Over the past two years, the stock has nearly tripled.

(c) Copyright Thomson Reuters 2014. Click For Restrictions - http://about.reuters.com/fulllegal.asp

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发表于 2014-2-7 22:41 |只看该作者
吉利德许可丙型肝炎药物在印度的低成本制造商

2014年2月5日下午05:58 ET


2月5日(路透社) - Gilead Sciences公司计划授权其突破性的丙型肝炎药物Sovaldi到一些印度仿制药生产商,允许在发展中国家低价格的销售药物,据该公司。

尽管价格对药物尚未确定,公司发言人尼克·弗朗西斯周三在一份电子邮件声明中表示,吉利德旨在建立“分层定价”。

例如,对于Sovaldi治疗24周讨论的价格将在公立医院,社区诊所和印度非政府机构经营的约2,500元对某些病人,印度教业务线在本周早些时候报道。

“在资源有限的环境提供了治疗提出了复杂的挑战,我们将与世界各地的多个部门的伙伴合作,以确保我们的访问程序到达尽可能多的患者可能的,”弗朗西斯说。

吉利德说,印度计划的最终细节将在未来几个月内公布。该公司拥有其艾滋病毒/艾滋病的药物成本较低的版本代替了类似的计划。

在美国,在那里Sovaldi已于十二月监管机构批准,该药物花费$ 84,000 12周治疗,或每日口服避孕药1,000元。

福斯特市,总部位于加州的公司负责人表示,价格是公平的,因为治疗提供了肝脏摧毁病毒潜在治疗无干扰素的注射,这可能会导致严重的副作用,妥协患者的治疗效果。

在欧洲的价格也比在美国低。的治疗费用,在英国是约57,000 ,而在德国的售价约为66,000该公司负责人表示。

分析家们估计,毒品最终会产生数十亿美元的年销售额。桑福德伯恩斯坦仅今年为67十亿已预测销售。

但有人质疑这是否是可以实现的。很多患者包括那些在美国,有超过丙型肝炎患者的一半,估计依靠公共资金,可能难以确保报销这样的高价药。

其他公司,包括强生公司, AbbVie和默克公司也正在努力开发新的丙肝治疗方法有一些在临床研究中的高级阶段。

基列,其中周二报道2013年的盈利,谢绝包括估计在其2014年销售预测丙型肝炎销售,只说Sovaldi销售至今一直坚挺和广泛的基础。

销售Sovaldi在过去三周2013年总额超过1.39亿美元。

据世界卫生组织估计,世界人口的三成左右已经感染了丙型肝炎病毒和170多万慢性携带者是在患肝硬化,肝癌或两者的风险。

基列的股价下跌3.87涨幅近百分之五,收于78.15美元在纳斯达克交易日(星期三) 。在过去的两年中,股票增长了近两倍。

版权所有(C)汤姆森路透2014年。点击对于限制 - http://about.reuters.com/fulllegal.asp
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