在日本正常血清谷丙转氨酶水平的上限

StephenW

http://onlinelibrary.wiley.com/doi/10.1111/hepr.12293/abstract
Original Article

The upper limit of normal serum alanine aminotransferase levels in Japanese
subjects

Kenichi Tanaka1,2,
Hideyuki Hyogo4,
Masafumi Ono5,
Hirokazu Takahashi1,2,*,
Yoichiro Kitajima1,3,
Naofumi Ono1,
Takahisa Eguchi1,
Kazuma Fujimoto2,
Kazuaki Chayama4,
Toshiji Saibara5,
Keizo Anzai2,
Yuichiro Eguchi3,
and the Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD)
DOI: 10.1111/hepr.12293

Abstract

Background

Serum alanine aminotransferase (ALT) is important for screening, diagnosis,
and management of chronic liver diseases. The incidence of non-alcoholic
fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH), which is
considered a hepatic manifestation of lifestyle-related diseases, is
increasing worldwide. However, the upper limit of the normal ALT level has
not yet been established because of not excluding many lifestyle-related
diseases. The aim of this study was to evaluate the upper limit of normal
serum ALT levels in Japanese subjects.

Methods

We analyzed the serum ALT levels of 11 404 Japanese subjects negative for
HBs-antigen and HCV-antibody, and who received health check-ups. Lifestyle
factors related to ALT levels were determined by multivariate analysis.
Subjects with all factors identified by multivariate analysis within the
normal range were defined as “healthy” subjects. The 90th percentile of
ALT levels in “healthy” subjects was defined as the upper limit of
normal ALT.

Results

Whereas alcohol intake was not a significant factor, gender; age; body mass
index (BMI); waist circumference; concentrations of total cholesterol,
high-density lipoprotein cholesterol, triglycerides, and fasting blood
glucose; and fatty liver on ultrasonography were independently associated
with ALT concentration by multivariate analysis. “Healthy” subjects
consisted of 1462 (21.2%) males and 2046 (45.4%) females and the 90th
percentiles of the ALT levels in the two groups were 29 IU/L in males and
23 IU/L in females.

Conclusions

The upper limits of normal ALT when considering lifestyle factors in
Japanese subjects were 29 IU/L in males and 23 IU/L in females.

StephenW

http://onlinelibrary.wiley.com/doi/10.1111/hepr.12293/abstract
原来的文章

在日本正常血清谷丙转氨酶水平的上限
主题

健一Tanaka1 ，2，
秀行Hyogo4 ，
雅文Ono5 ，
弘Takahashi1 ， 2 ， * ，
洋一郎Kitajima1 ， 3 ，
尚史Ono1 ，
贵久Eguchi1 ，
万马Fujimoto2 ，
和明Chayama4 ，
俊儿Saibara5 ，
敬三Anzai2 ，
雄一郎Eguchi3 ，
与非酒精性脂肪性肝病的日本研究小组（ JSG- NAFLD）
DOI ： 10.1111/hepr.12293

摘要

背景

血清丙氨酸转氨酶（ALT）是用于筛查，诊断有重要意义，
以及慢性肝脏疾病管理。非酒精性的发生率
脂肪肝疾病（NAFLD ） /非酒精性脂肪性肝炎（NASH ），这是
考虑的与生活方式有关的疾病的肝表现，是
世界范围内不断增加。然而，正常ALT水平的上限有
尚未建立，因为不排除很多生活方式相关的
疾病。本研究的目的是评估的正常上限
血清ALT水平在日本的科目。

方法

我们分析了11 404日本受试者血清ALT水平为负
乙型肝炎表面抗原和丙肝抗体，谁接受健康检查。生活方式
与ALT水平因素的多因素分析确定。
与内确定多变量分析所有因素主题
正常范围被定义为“健康”的主题。的第90个百分
在“健康”的受试者ALT水平被定义为上限
ALT正常。

结果

而酒精的摄入量是不是一个显著的因素，性别，年龄，体重
指数（BMI） ;腰围;总胆固醇浓度
高密度脂蛋白胆固醇，甘油三酯和空腹血糖
葡萄糖;超声检查和脂肪肝独立相关
由多因素分析ALT浓度。 “健康”科目
包括1462 （ 21.2 ％ ）的男性和2046 （ 45.4 ％ ），女性和90
在两组的ALT水平的百分位数为29 IU / L，男性和
23 IU / L ，女性。

结论

考虑生活方式因素时， ALT正常的上限在
日本受试者为29 IU / L，在男性和23 IU / L ，女性。