咖啡和茶可能有助于降低肝脏炎症的人与丙型肝炎

StephenW

                                                                                Coffee and Tea May Help Reduce Liver Inflammation in People with Hepatitis C                                                               

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                 Details                                                                                Category: HCV Disease Progression                                                                Published on Monday, 23 December 2013 00:00                                                        Written by Liz Highleyman               
                                                                                               

Image: Dreamstime

                                       
               
               
                Chronic hepatitis C patients who drink caffeinated filtered coffee on a daily basis were more likely to have lower alanine aminotransferase (ALT) levels, indicating less liver inflammation, according to a study published in the December 11, 2013, edition of PLoS ONE. Black or oolong tea also appeared to have a beneficial effect.

        Studies looking at the link between coffee, tea, or other caffeine-containing products and liver health have produced mixed results, but several have shown that coffee consumption is associated with reduced liver inflammation or lessened fibrosis. It is not clear whether the association is related to caffeine, plant phytochemicals, or other factors.
        Yachiyo Sasaki and colleagues from Osaka City University in Japan looked at the effect of coffee and tea consumption on serum ALT levels over 12 months among individuals with chronic hepatitis C.
        The analysis included 376 patients with detectable HCV RNA in a hospital-based cohort study recruited between August 2005 and July 2006. The majority (about 60%) were women and the mean age was approximately 65 years. People who started interferon-based therapy were excluded. About 60% had normal ALT (<45 IU/L) at baseline while the rest had elevated ALT. Extent of liver fibrosis or cirrhosis was not reported. About half never drank caffeinated filtered coffee and the remainder were roughly evenly divided between those who drank <1 cup per day and those who drank 1 cup or more daily.
        Results

•                 Among 229 participants with normal ALT at baseline, 81% still had normal ALT levels 12 months after recruitment.
•                 People who drank filtered caffeinated coffee daily were 3 times more likely to maintain normal ALT than those who did not drink filtered coffee (odds ratio [OR] 2.74; p=0.037).
•                 People who drank decaffeinated coffee, however, had a lower likelihood of maintaining normal ALT, though this fell short of statistical significance (OR 0.26; p=0.076).
•                 Among 147 patients with higher ALT levels at baseline, 27% experienced ALT reductions of at least 20 IU/L by 12 months after recruitment.
•                 People who drank filtered coffee had a significantly increased likelihood of ALT reduction (OR 3.79; p=0.034).
•                 No participants who drank decaffeinated experienced ALT reduction.
•                 People who drank 4 or more cups of black or oolong tea had a greater likelihood of having normal ALT than those who drank less.
•                 No significant associations were observed between consumption of unfiltered caffeinated coffee or green tea and ALT changes.
  

        Based on these findings, the study authors concluded, "Among patients with chronic HCV infection, daily consumption of filtered coffee may have a beneficial effect on the stabilization of ALT levels."
        "[F]iltered coffee consumption exerted a consistently beneficial effect during 12 months of follow-up, not only for sustained normal ALT levels among patients with normal baseline ALT levels, but also for ALT reduction among patients with higher baseline ALT levels," they elaborated in their discussion. "The key substances seemed to be included in filtered coffee," rather than unfiltered caffeinated coffee, they added.
        "The results of the present study suggest that consumption of black tea/oolong tea has a beneficial effect on serum ALT level after 12 months, both among patients with normal baseline ALT levels and among those with higher ALT levels," they continued. "To the best of our knowledge, this is the first study to report a favorable association between consumption of black tea/oolong tea and serum ALT level."
        12/23/13
        Reference
        Y Sasaki, S Ohfuji, W Fukushima, et al. Effect of Caffeine-Containing Beverage Consumption on Serum Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C Virus Infection: A Hospital-Based Cohort Study. PLoS ONE 8(12):e83382. December 11, 2013.

       

StephenW

慢性丙型肝炎患者谁喝含咖啡因的过滤咖啡，每天都更可能有降低谷丙转氨酶（ALT ）水平，表明少肝脏炎症，根据发表在12月11日2013年， PLoS ONE的版本进行研究。黑色或乌龙茶也似乎有一个有利的影响。

研究着眼于与咖啡，茶或其他含咖啡因的产品和肝脏健康的链路已经产生不同的结果，但有几个已经表明，饮用咖啡与降低肝脏炎症或纤维化减轻相关联。目前尚不清楚该协会是否与咖啡因，植物的植物化学物质，或其他因素。

八千代佐佐木和大阪市立大学的日本同事们在对血清ALT水平的咖啡和茶消费量的慢性丙型肝炎的个体在12个月内生效

该分析包括376例在2005年8月和2006年7月间招募了医院为基础的队列研究中检测到HCV RNA 。大部分（约60％）为女性，平均年龄为大约65年。人谁开始干扰素为基础的治疗被排除在外。约60 ％有ALT正常（ < 45 IU / L）在基线，而其余有ALT升高。没有报道肝纤维化或肝硬化的程度。大约有一半从未喝含咖啡因的过滤咖啡，而其余那些谁每天喝< 1杯和那些谁喝1杯或更多的日常之间进行了大致平分秋色。

结果

    其中229参与者在基线ALT正常， 81 ％的招聘后，仍然有正常的ALT水平12个月。
    谁的人每天喝过滤含咖啡因的咖啡是3倍更有可能维持正常的ALT谁比那些没有喝过滤咖啡（胜算比[OR] 2.74 ，P = 0.037 ） 。
    人谁喝不含咖啡因的咖啡，然而，有维持正常ALT的可能性较低，虽然这未达统计学意义（OR 0.26 ，P = 0.076 ） 。
    其中147例患者有较高的ALT水平在基线，至少20 IU / L， 27 ％有经验的ALT降低了招聘后的12个月。
    人谁喝过滤咖啡有降低ALT的显著可能性增加（OR 3.79 ，P = 0.034 ） 。
    不参加谁喝不含咖啡因的经验丰富的ALT下降。
    人谁喝4杯或更多黑色或乌龙茶有具有比那些谁喝少ALT正常的可能性更大。
    无显著协会的未经过滤的含咖啡因的咖啡或绿茶和ALT的变化量之间的变化。

基于这些发现，研究人员得出结论：“在治疗慢性丙型肝炎病毒感染，每天食用过滤咖啡可能对ALT水平的稳定产生有利的影响。 ”

“ [F] iltered咖啡消费过程中的随访12个月施加一个持续有利的影响，不仅对中正常的患者基线ALT水平持续正常的ALT水平，同时也为患者中ALT键还原具有较高的基线ALT水平， ”他们阐述了他们的讨论。 “关键物质似乎被包含在过滤咖啡”，而不是未经过滤的含咖啡因的咖啡，他们补充说。

“目前的研究结果表明，红茶/乌龙茶消费既有的患者有正常基线ALT水平和在那些具有较高的ALT水平对血清ALT水平产生有利的影响12个月后， ”他们继续。 “据我们所知，这是第一次研究报告红茶/乌龙茶和血清ALT水平的消费之间的良好关系。 ”

13年12月23日

参考

Ÿ佐佐木，S Ohfuji ，W福岛等。效果的咖啡因饮料含消费对血清谷丙转氨酶水平在慢性丙型肝炎病毒感染：以医院为基础的队列研究。 PLoS ONE的8 （ 12 ） ： e83382 。二○一三年十二月一十一日。