乙型和丙型肝炎肝脏硬度由ARFI （声辐射力脉冲） elastometry的

StephenW

Source: Clin Radiol  |  Posted 8 hours ago
Outcome analysis of liver stiffness by ARFI (acoustic radiation force impulse) elastometry in patients with chronic viral hepatitis B and C; Goertz R, Sturm J, Zopf S, Wildner D, Neurath M, Strobel D; Clinical Radiology (Dec 2013)



AIM To evaluate the association between liver stiffness measured by acoustic radiation force impulse (ARFI) elastometry and the outcome of antiviral treatment in patients with chronic viral hepatitis B and C.

MATERIALS AND METHODS Thirty-eight patients with chronic viral hepatitis B (n = 16) or hepatitis C (n = 22) underwent liver biopsy and ARFI elastometry of the right hepatic lobe. A follow-up assessment using ARFI was performed a mean of 2.3 years after the baseline evaluation. The patients with favourable outcome were classified in group S and those receiving no treatment, showing no response to treatment, or experiencing a relapse were classified in group N.

RESULTS The 38 patients had an initial mean ARFI value of 1.56 ± 0.62 m/s as compared with 1.54 ± 0.64 m/s in the follow-up evaluation. Group S showed a significant decline in ARFI values (1.55 ± 0.60 m/s versus 1.34 ± 0.47 m/s; p < 0.05) and included 16 (64%) patients with lower shear wave velocities at follow-up. In group N, liver stiffness values showed a slight but not significant increase (1.57 ± 0.70 m/s versus 1.93 ± 0.77 m/s).

CONCLUSION Changes in liver stiffness during antiviral therapy can be assessed by ARFI reflecting response or no response. ARFI elastometry is an additional, useful tool for the follow-up assessment of treatment outcome in patients with chronic viral hepatitis B or C infection.

StephenW

来源：临床放射学杂志|帖子8小时前
高尔茨R，斯特姆Ĵ ， Zopf S，威尔德纳D，纽拉特M，斯特罗贝尔D组; ;肝脏硬度由ARFI （声辐射力脉冲） elastometry患者的慢性病毒性肝炎乙型和丙型肝炎的疗效分析临床放射学杂志（ 2013年12月）

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        肝炎

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目的为了评估由声辐射力脉冲（ ARFI ） elastometry和抗病毒治疗的慢性病毒性肝炎B和C的结果测量肝脏硬度之间的关联

材料与方法38例慢性乙型肝炎（N = 16）或丙型肝炎（N = 22 ）进行肝活检和肝右后叶的ARFI elastometry 。一个用ARFI后续评估，进行了平均2.3年后的基线评估。患者有利的结果被分为S组和那些没有接受治疗，显示出对治疗无反应，或遇到复发被归类在N组

结果38例患者为1.56 ±0.62米/秒的初始平均ARFI值与1.54 ±0.64米/秒的随访评估比较。 S组显示， ARFI值显著下降（ 1.55 ±0.60米/秒与1.34 ±0.47米/秒，P < 0.05 ），并包括16名（ 64 ％）患者有较低的剪切波速随访。在N组，肝脏硬度值呈小幅但不显著增加（ 1.57 ±0.70米/秒与1.93 ±0.77米/秒） 。

在抗病毒治疗的结论改变肝脏硬度可以通过ARFI反射反应或无反应进行评估。 ARFI elastometry是用于治疗结果患者的慢性病毒性肝炎乙型或丙型肝炎病毒感染的随访评估一个额外的，有用的工具。