汉族人乙肝病毒感染新易感基因发现

StephenW

汉族人乙肝病毒感染新易感基因发现更新时间：2013-11-11    作者：程守勤 蔡…    文章来源：健康报
　　本报讯 （记者程守勤通讯员蔡心轶）日前，南京医科大学、江苏省疾病预防控制中心、上海交通大学等多家机构的研究人员，通过全基因组关联研究鉴别出了中国汉族人群乙型肝炎病毒感染相关的两个全新易感基因。该研究为乙肝的遗传病因提供了新的见解，相关论文日前发表在国际期刊《自然・遗传学》上。
　　宿主的天然免疫在机体抵抗乙肝病毒感染的过程中非常关键，因而机体遗传因素（即宿主对乙肝病毒的遗传易感性）在乙肝发病和预后等方面起着尤为重要的作用。
　　为了鉴别汉族人群中与乙肝病毒感染相关的遗传位点，研究人员设计了一种三阶段全基因组关联研究。在发现阶段，研究人员对951名慢性乙肝病毒携带者和937名已自然清除乙肝病毒感染的对照个体进行了分析。随后，在第二和第三重复阶段，对来自一般人群的一组2248名慢性乙肝病毒携带者和3051名对照个体，以及另一组1982名慢性乙肝病毒携带者、2622名对照者进行了关联验证。研究人员鉴别出了与乙肝病毒感染相关的两个新位点：6p21.33上的s3130542，靠近HLA-C；以及22q11.21上的rs4821116，定位在UBE2L3中。
　　南京医科大学公共卫生学院沈洪兵教授、胡志斌教授，第二军医大学周伟平教授以及上海交通大学研究所师咏勇研究员是这篇论文的共同通讯作者。

为了小心肝

bigben446

http://www.ncbi.nlm.nih.gov/pubmed/24162738?dopt=Abstract
Nat Genet. 2013 Oct 27. doi: 10.1038/ng.2809. [Epub ahead of print]
New loci associated with chronic hepatitis B virus infection in Han Chinese.
Hu Z, Liu Y, Zhai X, Dai J, Jin G, Wang L, Zhu L, Yang Y, Liu J, Chu M, Wen J, Xie K, Du G, Wang Q, Zhou Y, Cao M, Liu L, He Y, Wang Y, Zhou G, Jia W, Lu J, Li S, Liu J, Yang H, Shi Y, Zhou W, Shen H.
Source
1] Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Department of Epidemiology & Biostatistics, Nanjing Medical University, Nanjing, China. [2] State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China. [3].

Abstract
Chronic hepatitis B virus (HBV) infection is a challenging global health problem. To identify genetic loci involved in chronic HBV infection, we designed a three-phase genome-wide association study in Han Chinese populations. The discovery phase included 951 HBV carriers (cases) and 937 individuals who had naturally cleared HBV infection (controls) and was followed by independent replications with a total of 2,248 cases and 3,051 controls and additional replications with 1,982 HBV carriers and 2,622 controls from the general population. We identified two new loci associated with chronic HBV infection: rs3130542 at 6p21.33 (near HLA-C, odds ratio (OR) = 1.33, P = 9.49 × 10-14) and rs4821116 at 22q11.21 (in UBE2L3, OR = 0.82, P = 1.71 × 10-12). Additionally, we replicated the previously identified associations of HLA-DP and HLA-DQ variants at 6p21.32 with chronic HBV infection. These findings highlight the importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP and HLA-DQ.
PMID: 24162738 [PubMed - as supplied by publisher]