据说扶正化瘀的临床实验结果将在aasld上公布，有消息了吗？

重肝过后

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StephenW

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我找不到. 需要更多的细节：一个名字?

重肝过后

StephenW 发表于 2013-10-11 19:38
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我找不到. 需要更多的细节：一个名字?

不知道名字啊，只是在微博上看到这个消息。我去aasld网站上只看到扶正化瘀的生产商将会参会……

StephenW

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生产商的名字?

重肝过后

StephenW 发表于 2013-10-11 19:48
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ooth: 510

Shanghai Sundise Traditional Chinese Medicine Co., Ltd

StephenW

[tr][/tr]

TITLE: Levistilide A inhibits liver fibrosis and angiogenesis

AUTHORS (FIRST NAME, LAST NAME): Zhimin Zhao1, Ye Tan1, Tao Guo1, Chenghai Liu1, 2

Institutional Author(s):

INSTITUTIONS (ALL): 1. Institute of Liver Disease, ShuGuang Hospital, Shanghai University of Traditional Chinese Medicine, of Shanghai Academy of Traditional Chinese Medicine,  201203, China;, Shanghai, China. 2. E-Institute of Traditional Chinese Medicine Internal Medicine, Shanghai, 201203, China;, Shanghai, China.

ABSTRACT BODY: Background and Aimevistilide A (the molecular weight is 380.48 and the formula is C24H28O4) is derived from Angelica Sinensis which has action of protecting liver injury in our previous works. In this study, we investigated its effects on liver fibrosis and angiogenesis in vivo and in vitro. Methods: Liver fibrosis was induced by hypodermic injection of CCl4 for 6 weeks in rats, and treated with 3 mg/kg and 6 mg/kg of Levistilide A from the 4th week of CCl4 intoxication to the end of experiment. Liver inflammation and fibrosis were observed by H&E and Sirius red staining, liver microvasculature was examined by synchrotron radiation X-ray two-dimensional imaging. Sinusoidal fenestration was detected by scanning electron microscope. SK-HEP-1 cells, a hepatic endothelial cell line, was hypoxia-induced by CoCl2. Cell viability was analyzed by MTT assay. vWF expression was examined by immunofluorescent staining. The levels of NO and NOS were observed by fluorescence probe. Tube formation assay and transgenic Zebrafish model were also performed. Results: Levistilide A attenuated liver inflammation and fibrosis in CCl4 rats. It could reduce hepatic microvessel texture and improve sinusoidal capillarization in vivo. It also could inhibit tube formation and the formation of functional vessels in transgenic zebrafish. It could protect SK-HEP-1 cells from the hypoxia injury, and decrease vWF protein expression but promote NO production in vitro. Conclusion: Levistilide A had potent effects against liver fibrosis and angiogenesis in vivo and in vitro. Keywords: Levistilide A; fibrosis; angiogenesis

(No Table Selected)

Effects of Levistilide A on Liver fibrosis and angiogenesis. (A) Sirius red staining. (B) Synchrotron radiation 2-d imaging. (C) Scanning electron microscope. (D) Transgenic Zebrafish. (E) The structure of Levistilide A.

Co-Author Disclosure Status

The following authors have completed their AASLD 2013 disclosure: Zhimin Zhao: Disclosure completed | Ye Tan: Disclosure completed | Tao Guo: Disclosure completed | Chenghai Liu: Disclosure completed

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[/table][table]

StephenW

标题： Levistilide的A抑制肝纤维化和血管生成
香港（姓氏，名字） ，叶TAN1 ，陶果1 ，2 ，澄海刘志敏Zhao1
机构作者（次） ：
机构（ ALL ） ：1。肝病研究所，曙光医院，上海大学中国传统医药，传统中国医学科学院，上海201203 ，中国，上海，中国。
2。 E-研究院，中国中西医结合内科，上海， 201203 ，中国，上海，中国。
抽象的身体：背景和目的： Levistilide的A（分子量为380.48和计算公式为C24H28O4 ）来自当归具有保护肝损伤的作用在我们以前的作品。在这项研究中，我们调查了其对肝纤维化在体内和体外血管生成的影响。方法：通过皮下注射四氯化碳诱导肝纤维化大鼠6周，并与3毫克/公斤和6毫克/公斤的Levistilide从四氯化碳中毒第四周实验结束处理。由H＆ E和天狼星红染色观察肝脏的炎症和纤维化，肝微血管同步辐射X射线二维成像检查。正弦开窗，通过扫描型电子显微镜检测。 SK - HEP -1细胞，肝内皮细胞株，缺氧诱导的氯化钴。 MTT法检测细胞活力分析。 vWF的表达进行了检查，免疫荧光染色。 NO水平和NOS观察荧光探针。还进行管形成实验和转基因斑马鱼模型。结果四氯化碳大鼠减毒肝脏炎症和纤维化Levistilide 。它可以减少肝微血管纹理的改善肝窦毛细血管在体内。它也可以抑制管的形成和功能的转基因斑马鱼血管形成。它可以保护SK - HEP - 1细胞的缺氧损伤，并降低vWF蛋白表达，促进NO的体外生产。结论： Levistilide有强有力的影响在体内和体外抗肝纤维化和血管生成。关键词： Levistilide A;纤维化;血管生成

（未选择表）

的Levistilide A对肝纤维化和血管生成的影响。 （ A ）天狼星红染色。 （ B ） 2 -D成像同步辐射。 （ C ）扫描电子显微镜。 （四）转基因斑马鱼。 （ E ）的结构Levistilide A.

StephenW

抱歉，找不到:
扶正化瘀（FZHY）
www.clinicaltrials.gov（标识符：NCT00854087）
美国Ⅱ期临床试验是在2009年启动，用于治疗丙型肝炎患者的肝纤维化。

重肝过后

StephenW 发表于 2013-10-11 21:22
抱歉，找不到:
扶正化瘀（FZHY）
www.clinicaltrials.gov（标识符：NCT00854087）

谢谢，还是再等等看吧。