探讨血清维生素D水平和自发乙肝表面抗原（HBsAg）转阴之间

StephenW

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692974/

AIM: To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.

METHODS: Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.

RESULTS: Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA  8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.

CONCLUSION: We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.

StephenW

目的：探讨血清维生素D水平和自发乙肝表面抗原（HBsAg）转阴之间可能有关联。

方法：随访53例确诊为慢性非活动性肝炎B和自发的HBsAg转阴两名以色列肝单位在2007年和2012年之间。这项回顾性研究审查了所有患者的病历，人口，血清学和维生素D的汇率提取血清，以及医疗条件和当前的医疗治疗。自发的HBsAg血清清除定义为血清HBsAg无限期的损失。维生素D水平进行了比较，所有患者进行自发的HBsAg转阴。

结果：53名患者进行乙肝抗原转阴，44例（83％），25  - 羟基维生素D的正常水平相比，9例（17％）低于正常水平。多因素分析显示，年龄（>35岁）OR=1.7（95％CI：1.25-2.8，P =0.05），血清维生素D水平（>20毫微克/毫升）OR=2.6（95％CI：2.4-3.2， P = 0.02），乙肝e抗原阴性OR= 2.1（95％CI：2.2-3.1，P =0.02），低病毒载量（乙肝病毒DNA的8岁）OR= 1.6（95％CI：1.15-2.6， P= 0.04），还伴有自发性HBsAg的转阴。

结论：我们发现有很强的相关性之间的正常的维生素D水平和自发的HBsAg转阴。

StephenW

Vitamin D is essential for strong bones, muscles and overall health. Ultraviolet (UV) radiation from the sun is necessary for the production of vitamin D in the skin and is the best natural source of vitamin D.

UV radiation from the sun is also the main cause of skin cancer. Taking a balanced approach to sun exposure can help make sure you get enough vitamin D while minimising your skin cancer risk.

To boost your vitamin D levels when in the sun, expose at least your face, arms and hands, or equivalent area of skin. For vitamin D to be produced, your skin must not be covered with clothing.

Prolonged sun exposure will not increase vitamin D levels further, but will increase the risk of skin cancer. Solariums should never be used to boost vitamin D, as they emit dangerous levels of UV that increase the risk of skin cancer.

Daily exercise also assists with the body’s production of vitamin D

维生素D是必不可少的强筋骨，肌肉和整体健康。来自太阳的紫外线（UV）辐射在皮肤上用于生产维生素D是必要的，并且是最好的天然来源的维生素D。

来自太阳的紫外线辐射是皮肤癌的主要原因。阳光下暴晒以一种平衡的方法，可以帮助确保你得到足够的维生素D，同时最大限度地降低皮肤癌的风险。

要提高维生素D水平在阳光下的时候，至少你的脸，胳膊和手，或等效面积的皮肤暴露。对于维生素D的产生，你的皮肤不能有衣服。

爆晒不会进一步增加维生素D的水平，但会增加皮肤癌的风险。日光浴不应该被用来提高维生素D，因为他们发出危险程度的紫外线，增加皮肤癌的风险。

日常锻炼也有助于维生素D与人体的生产