维生素D缺乏可能帮助乙肝的传播在整个肝

StephenW

Vitamin D Deficiency May Help Spread Of Hepatitis B Throughout Liver
June 6, 2013
   
   

Researchers from Germany have found that low levels of vitamin D are associated with high levels of hepatitis B virus (HBV) replication. Findings published online in Hepatology, a journal of the American Association for the Study of Liver Diseases, suggest seasonal fluctuations in vitamin D and HBV levels point to a link in these variables among patients with chronic HBV.

While highly effective vaccines are available, HBV still remains one of the most significant infectious diseases worldwide. In fact, the World Health Organization (WHO) states that HBV is 50 to 100 times more infectious than human immunodeficiency virus (HIV). Furthermore WHO reports that two billion individuals have been infected with HBV, which is responsible for nearly 600,000 deaths each year. In the U.S. the Centers for Disease Control and Prevention (CDC) estimates that up to 1.4 million Americans are living with chronic HBV.

“Vitamin D helps maintain a healthy immune system and there is evidence of its role in inflammatory and metabolic liver disease, including infection with hepatitis C virus (HCV),” explains lead investigator Dr. Christian Lange from Johann Wolfgang Goethe University Hospital in Frankfurt. “However, the relationship between vitamin D metabolism and chronic HBV infection remains unknown and is the focus of our present study.”

Between January 2009 and December 2010, the team recruited 203 patients with chronic HBV who had not previously received treatment for their infection. Levels of 25-hydroxyvitamin D were measured from each participant. Patients co-infected with HCV, HIV, or hepatitis D; those with excessive alcohol use; and those with liver cancer or other malignancies were excluded.

Results show that 34% of participants had severe vitamin D deficiency (less than 10 ng/mL), 47% with vitamin D insufficiency (between 10-20 ng/mL) and 19% had normal levels of vitamin D (greater than 20 ng/mL). Further analyses indicate that the concentration of HBV in the blood, known as viral load, was a strong indicator of low vitamin D levels. In patients with HBV DNA less than 2000 IU/mL versus 2000 IU/mL or more, the levels of vitamin D were 17 and 11 ng/mL, respectively.

Researchers also determined that patients with the hepatitis B antigen (HBeAg) had lower levels of vitamin D than HBeAg negative participants. Inverse seasonal fluctuations between vitamin D and HBV levels were noted, which further suggests a relationship between the two variables.

“Our data confirm an association between low levels of vitamin D and high concentrations of HBV in the blood,” concludes Dr. Lange. “These findings differ from previous research of patients with chronic hepatitis C, which found no connection between vitamin D levels and concentration of HCV in the blood.” The authors propose further investigation of vitamin D as a therapeutic intervention for controlling HBV.

StephenW

来自德国的研究人员发现，维生素D水平低都与高水平的乙肝病毒（HBV）复制。肝脏病杂志，一本杂志的美国肝病研究协会在网上公布的调查结果，表明维生素D和HBV水平在慢性乙肝患者中的链接，这些变量的季节性波动。

虽然高度有效的疫苗是可用的，乙肝病毒仍然是世界的最显着的感染性疾病之一。事实上，世界卫生组织（WHO）指出，乙肝病毒比人类免疫缺陷病毒（HIV）感染的50到100倍以上。此外，世卫组织报告说，20亿个人已经感染了乙肝病毒，这是负责近60万，每年死亡人数。在美国疾病控制和预防中心（CDC）估计，多达140万美国人的生活与慢性乙肝。

“维生素D有助于保持一个健康的免疫系统，并解释说：”有证据显示它的作用，炎症，代谢和肝脏疾病，包括感染丙型肝炎病毒（HCV），首席研究员约翰·沃尔夫冈·歌德大学医院在法兰克福基督教兰格博士。然而，维生素D代谢和慢性HBV感染者之间的关系仍然不明，是我们目前研究的重点。“

2009年1月至2010年12月，球队招募了203名慢性乙肝患者以前没有接受治疗的感染。从每个参与者的25  - 羟基维生素D的水平。感染丙型肝炎病毒，艾滋病毒，丁型肝炎的患者，那些过量饮酒以及那些与肝癌或者其他恶性肿瘤被排除在外。

结果表明，34％的参与者有严重的维生素D缺乏（低于10毫微克/毫升），与维生素D不足（10-20毫微克/毫升）的47％和19％的维生素D的正常水平（大于20毫微克/毫升）。进一步的分析表明，乙肝病毒的浓度，被称为病毒载量，血液中的维生素D水平低的一个重要标志。维生素D水平与HBV DNA小于2000 IU / mL对2000 IU /毫升或更多的患者，分别为17和11毫微克/毫升，分别。

研究人员还确定，与B型肝炎抗原（HBeAg）的患者HBeAg阴性的参与者相比，维生素D水平较低。则逆季节性的波动之间的维生素D和HBV水平，这进一步表明两个变量之间的关系。

“我们的数据证实低水平的维生素D和乙肝病毒在血液中的高浓度之间的关联，”兰格博士的结论。 “这些发现患者的慢性丙型肝炎，没有发现维生素D水平和丙型肝炎病毒在血液中的浓度之间的连接从以往的研究不同。”作者建议进一步研究维生素D控制乙肝的治疗干预。