APALS2013 维生素D水平调查非活动乙肝病毒携带者

StephenW

Abstract
   
Investigation of Vitamin D Levels in Patients with Inactive Hepatitis B Virus Carrier   
     
Sedat Motor1, Vicdan Koksaldi Motor2, Cumali Gokce3, Ihsan Ustun3, Omer Evirgen2, Nigar Yilmaz1, Yusuf Onlen2
1Department of Biochemistry, 2Department of Infectious Disease and Clinical Microbiology, 3Department of Endocrinology and Metabolism, Mustafa Kemal University Medical School, Hatay, Turkey

Introduction: Vitamin D is a pluripotent secosteroid hormone that is well-known classical actions in calcium homeostasis and bone metabolism. The spectrum of nonclassic actions to vitamin D was including effects of vitamin D on the immune system. The aim of the present study was to investigate vitamin D levels in inactive HBV carriers in case of why the disorder is the mildest form of the chronic hepatitis B infection.
Materials and methods: A total of 81 patients with inactive hepatitis B virus carrier state were enrolled at the study. Serum calcium (Ca++), phosphorus (PO4), total protein, albumin, parathormone (PTH) and 25-hydroxy vitamin D (25OHD) were determined. Serum vitamin D concentration was categorized as deficient when it was less than 50 nmol/l (20 ng/ml), insufficient when it was 52.5-72.5 nmol/l (21-29 ng/ml), and sufficient when it was more than 75 nmol/l (30-100 ng/ml)
Results: The mean 25OHD level was found to be 131.7±50.0 nmol/l. Deficiency and insufficiency was seen in one (1.2%) and nine (11.1%) inactive hepatitis B virus carriers, respectively. All the patients have normal, serum PTH and albumin levels. Total Ca++ and PO4 were low in ten and eight patients, respectively. Vitamin D, Ca++ and albumin levels in the male group were found significantly higher than female group (p˂0.05).
Conclusion: The interactivity between the HBV and host immune response determines the final consequent of the infection. Vitamin D may cause the stimulation of antiviral immune response and a preventive effect on necroinflammation and liver fibrosis. Therefore, it may affect course of HBV infection. Further studies are needed to clarify this association. Also, studies with larger sample are needed to investigate the role of vitamin D in the course of chronic HBV infection, liver failure, cirrhosis and hepatocellular carcinoma.


Assigned speakers:
Dr. Vicdan Koksaldi Motor, Mustafa Kemal University Medical School , Hatay , Turkey

Assigned in sessions:
07.06.2013, 08:30-17:30, PT

StephenW

简介：维生素D是一个多能的开环​​甾类化合物是著名的古典行动钙平衡和骨代谢的激素。对维生素D的非经典动作的频谱，包括维生素D对免疫系统的影响。本研究的目的是探讨在非活动性HBV携带者的情况下为什么疾病是慢性乙肝感染的最温和的形式的维生素D水平。
就读于研究材料和方法：一共有81例无效乙肝病毒携带者状态。血清钙（Ca + +），磷（PO 4），总蛋白，白蛋白，甲状旁腺激素（PTH）和25  - 羟基维生素D（25OHD）进行了测定。血清维生素D浓度归类为缺陷，当它是小于50 nmol / L的（20毫微克/毫升），没有足够的，当它是52.5-72.5 nmol / L的（21-29毫微克/毫升），和足够的，当它是超过75 nmol / L的（30-100毫微克/毫升）
结果：25OHD的平均水平为131.7±50.0 nmol / L的。一（1.2％）和9例（11.1％），无效的乙肝病毒携带者，分别被视为缺乏和不足。所有患者具有正常血清PTH和白蛋白水平。总的Ca + +和PO4低十个八个患者，分别。维生素D，钙离子和白蛋白水平在男性组显着高于女性组（P˂0.05）。
结论：乙肝病毒和宿主的免疫反应之间的互动，确定感染的最终结果。维生素D可能会导致抗病毒免疫应答的刺激和坏死性炎症和肝纤维化的预防作用。因此，它可能会影响HBV感染的过程。还需要进一步研究，以澄清该协会。此外，需要较大的样本研究调查的作用的维生素D在慢性HBV感染，肝功能衰竭，肝硬化和肝癌的过程中。