APASL2013 比较肝组织ALT轻度升高HBeAg阳性和阴性的患者

StephenW

Comparison of Liver Histopathology between HBeAg-positive and HBeAg-negative Chronic Hepatitis B Patients with Mildly Elevated ALT   
  比较肝组织病理学之间的HBeAg阳性和HBeAg阴性慢性乙型肝炎患者ALT轻度升高   
Yue-Qiu Gao1, Xue-Hua Sun1, Xiao-Jun Zhu1, Man Li2, Lu Li3
1Department of Hepatopathy, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 2Laboratory of Cellular Immunology, Shuguang Hospital Attached with Shanghai Chinese Medicine University, 3Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

Objective: To study the histopathological features of chronic hepatitis B (CHB) with mildly elevated ALT (1×ULN£ALT£2×ULN).
Methods: 516 CHB patients with mildly elevated ALT were enrolled in this study, and they were categorized into HBeAg(+) group and HBeAg(-) group, and the results of serology and liver biopsy were analyzed.
Results:
(1) Compared with HBeAg(+) group, serum HBV-DNA and HBsAg levels were significantly decreased and α2- macroglobulin level was significantly increased in HBeAg(-) group (P< 0.001, P < 0.01).
(2) There were no significant differences in liver inflammation grade and fibrosis stage between HBeAg (+) group and HBeAg (-) group (P>0.05).
(3) Serum HBVDNA level was positively correlated with liver inflammation grade and fibrosis stage (r=0.248, r=0. 277, P < 0.05) in HBeAg(-)group.
(4) Serum HBsAg level was negatively correlated with liver inflammation grade and fibrosis stage (r=-0.239, r=-0.224, P< 0.001) and serum HBeAg level was negatively correlated with liver inflammation grade and fibrosis stage (r=-0.278, r=-0.272, P< 0.001) in HBeAg (+) group.
(5) Serum HA level was positively correlated with liver inflammation grade and fibrosis stage (r=0.270, r=0.228, P< 0.001) and serum α2- macroglobulin level was positively correlated with liver inflammation grade and fibrosis stage (r=0.170, r=0.131, P< 0.05) in HBeAg (+) group.
Conclusion: In HBeAg(+) patients, serum HBsAg and HBeAg levels were negatively correlated with liver pathology stage, and serum HA andα2- macroglobulin levels were positively correlated with liver pathology stage. In HBeAg (-) patients, serum HBV-DNA level was positively correlated with liver pathology stage.


Assigned speakers:
Prof. Yue-Qiu Gao, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine , Shanghai , China

Assigned in sessions:
07.06.2013, 08:30-17:30, PT-4, HEP B Clinical, Exhibition Hall

StephenW

目的：研究组织病理学特征的慢性乙型肝炎（CHB）ALT轻度升高（1×ULN<ALT<2×ULN）。
方法：516 ALT轻度升高的慢性乙肝患者参加了这项研究，他们被分为HBeAg阳性组和HBeAg（ - ）组，血清学和肝活检的结果进行了分析。
结果：
（1）组，血清HBV-DNA和HBsAg水平显着下降，α2-巨球蛋白水平显着增加，大三阳与HBeAg（+）（ - ）组（P <0.01，P <0.01）。
（2）在肝脏炎症分级，纤维化分期之间无显着差异e抗原（+）组和HBeAg（ - ）组（P> 0.05）。
（3）血清HBVDNA水平呈正相关，与肝脏炎症分级，纤维化分期（R = 0.248，R = 0。277，P <0.05），HBeAg阴性（ - ）组。
（4）血清HBsAg水平呈负相关，与肝脏炎症分级和纤维化分期（R = -0.239，R = -0.224，P <0.001）和血清HBeAg水平呈负相关，与肝脏炎症分级和纤维化分期相关（r = -0.278 ，R = -0.272，P <0.001），e抗原（+）组。
（5）血清HA水平呈正相关，与肝脏炎症分级和纤维化分期（0.270，R = 0.228，P <0.001）和血清α2-巨球蛋白水平呈正相关，与肝脏炎症分级和纤维化分期相关（r = 0.170， ŗ= 0.131，P <0.05），e抗原（+）组。
结论：对于HBeAg（+）患者中，血清HBsAg和HBeAg水平与肝脏病理分期呈负相关，与肝脏病理分期和血清HA和α2-巨球蛋白水平呈正相关。在HBeAg（ - ）患者，血清HBV-DNA水平呈正相关，与肝脏病理分期。

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