HLA-DP和IL28B宿主基因组多态性影响慢性乙型肝炎的乙型肝炎表

StephenW

HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B                                                

• Wai-Kay Seto1,a,
• Danny Ka-Ho Wong1,2,a,
• Malgorzata Kopaniszen1,
• Petroula Proitsi3,
• Pak-Chung Sham3,
• Ivan Fan-Ngai Hung1,
• James Fung1,2,
• Ching-Lung Lai1,2, and
• Man-Fung Yuen1,2
  

+ Author Affiliations

                  

• 1Department of Medicine
• 2State Key Laboratory for Liver Research, The University of Hong Kong, Queen Mary Hospital                        
• 3Center for Genomic Sciences, The University of Hong Kong                        
  

                  

• Correspondence: Man-Fung Yuen, MD, Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Pokfulam Rd,                        Hong Kong ([email protected]).
  

                  

•                         

  ↵a W. K. S. and D. K.-H. W. contributed equally to this work.                        

  
  

               
                                 Abstract                                    

Background. The roles of single-nucleotide polymorphisms (SNPs) at HLA-DP and IL28B loci on hepatitis B surface antigen (HBsAg) seroclearance in chronic hepatitis B (CHB) infection are unknown.                  

                                    

Methods. We compared the HLA-DP (rs3077, rs9277378, rs3128917) and IL28B (rs12979860, rs8099917) polymorphisms of 203 CHB patients achieving spontaneous HBsAg seroclearance with 203 age- and sex-matched                     CHB patients without HBsAg seroclearance (controls).                  

                                    

Results. The distribution of all 5 polymorphisms was in Hardy-Weinberg equilibrium. HLA-DP rs3077 was associated with HBsAg seroclearance in terms of allelic frequency (minor allele A vs major allele G, P = .035; odds ratio [OR], 0.699; 95% confidence interval [CI], .501–.976) and genotypic frequency (AA vs GG/GA, P = .014; OR, 0.295; 95% CI, .106–.822). Haplotype analysis of HLA-DP polymorphisms showed haplotype block GAT (rs3077/rs9277378/rs3128917) to be associated with HBsAg seroclearance (OR, 2.17;                     95% CI, 1.06–4.45, P = .034). Influence of HLA-DP polymorphisms on HBsAg seroclearance was more pronounced in younger patients, with the OR for rs3077 minor allele A and haplotype                     block GAT being 0.560 and 2.68, respectively, among patients aged <50 years (P = .027 and P = .047, respectively). IL28B haplotype block CG (rs12979860/rs8099917) was associated with HBsAg seroclearance (OR, 10.5, P = .026). None of the 5 polymorphisms influenced anti-HBs positivity among patients achieving HBsAg seroclearance, or serum                     HBV DNA and HBsAg titers among controls (P > .05).                  

                                    

Conclusions. Specific SNPs in HLA-DP and IL28B locus, through individual and haplotype analysis, were associated with a higher chance of HBsAg seroclearance in CHB infection.                     The associations were more prominent in patients with HBsAg seroclearance at a younger age.                  

                                 
               Key words

StephenW

背景。乙肝表面抗原（HBsAg）转阴，慢性乙型肝炎（CHB）感染的HLA-DP和IL28B基因座的单核苷酸多态性（SNPs）的角色是未知的。

方法。我们比较了HLA-DP（rs3077，rs9277378，rs3128917）和IL28B（了rs12979860，rs8099917）多态性实现203年龄和性别匹配的CHB患者无自发的HBsAg转阴，乙肝表面抗原转阴（对照组）203例慢性乙型肝炎患者。

的结果。所有5多态性分布Hardy-Weinberg平衡。 HLA-DP rs3077伴有乙肝表面抗原转阴的等位基因频率（次要等位基因A对主要等位基因G，P = 0.035，比值比[OR]为0.699; 95％信心区间[CI]，.501  -  .976）和基因型频率（AA与GG / GA，P = 0.014; OR，0.295; 95％CI，0.106  -  .822）。 HLA-DP基因多态性的单倍型分析显示，单倍型块GAT（rs3077/rs9277378/rs3128917）是与乙肝表面抗原转阴（OR，2.17，95％CI，1.06-4.45，P = .034）。 HLA-DP基因多态性对乙肝表面抗原转阴的影响更为明显，在年轻患者或rs3077次要等位基因A和单倍型块GAT分别为0.560和2.68，其中年龄<50岁的患者（P = 0.027和P =。 047，分别）。 IL28B单倍型块CG（rs12979860/rs8099917）是与乙肝表面抗原转阴（OR = 10.5，P = .026）。没有5多态性影响抗-HBs阳性的患者中，达到乙肝表面抗原转阴或血清HBV DNA和HBsAg滴度之间的对照组（P> 0.05）。

结论。特定的SNP位点，通过个人和单倍型分析，相关HLA-DP和IL28B基因在慢性乙型肝炎感染乙肝表面抗原转阴的机会较高。该协会在与乙肝表面抗原转阴的患者有年轻化更加突出。

MP4

与干扰素的关系是？

StephenW

MP4 发表于 2013-5-21 00:27
与干扰素的关系是？

我不知道. 对于HCV，更好的干扰素响应.