我也来发个肝硬化治疗进展的新闻~~

flying_dutchman

之前看到论坛里有什么西伯利亚科学家发现治疗肝硬化新药的消息，还小小的兴奋了一下，在网上搜了些相关信息，感觉有点忽悠的成分，俄罗斯的医学水平也不见得高，之前查clinicaltrials.gov里面看到俄罗斯关于肝病研究还没中国做得多 ，那个什么西伯利亚的新闻 除了自己的宣传之外 没有其他权威医学媒体的报道。

flying_dutchman

刚看到有个新闻 ，感觉还可以 发来大家一起看一下 ，鼓励一下自己 也鼓励下别人，科学在进步，说不定什么时候肝硬化就可以治好，大家统统加油！！

flying_dutchman

http://www.sciencedaily.com/releases/2013/04/130425160125.htm

Sunshine Hormone, Vitamin D, May Offer Hope for Treating Liver Fibrosis

Apr. 25, 2013 — Liver fibrosis results from an excessive accumulation of tough, fibrous scar tissue and occurs in most types of chronic liver diseases. In industrialized countries, the main causes of liver injury leading to fibrosis include chronic hepatitis virus infection, excess alcohol consumption and, increasingly, nonalcoholic steatohepatitis (NASH).

Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form of vitamin D, calcipotriol (a drug already approved by the FDA for the treatment of psoriasis), deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.

"Because there are currently no effective drugs for liver fibrosis, we believe our findings would open a new door for treatment," says senior author Ronald M. Evans, a professor in Salk's Gene Expression Laboratory and lead researcher in the Institute's new Helmsley Center for Genomic Medicine.

flying_dutchman

我也不是学医的，试着翻译一下，大家可以一起探讨下看对不对

Sunshine 荷尔蒙，维生素D，可能提供治疗肝纤维化的希望

2013年4月25日
肝纤维化是肝脏的过度损伤不断累积，纤维组织不断增生的结果，是较多发的慢性肝病。在工业化国家，肝损伤导致的肝纤维化的主要原因包括慢性肝炎病毒感染，过量饮酒，以及越来越多的非酒精性脂肪性肝炎。
现在，在《cell 》期刊上面刊登了一项新的研究，Salk研究院的科学家发现一种维他命D合成物calcipotriol （此药已经用于治疗牛皮癣）抵消了小鼠肝脏细胞的纤维化响应，提出了一条治疗人类纤维化疾病的潜在途径。


“因为目前对肝纤维化还没有有效的药物，我们相信，我们的研究结果将打开一扇新的大门，””Salk学院生物基因表达实验室教授，新赫尔姆斯利组医学中心的首席研究员罗纳德M.伊万斯说。

flying_dutchman

The Salk study focused on a star-shaped "stellate" cell in the liver that serves as a beacon for damage. When called into action, stellate cells produce fibrotic proteins in an attempt to heal an injury. Under chronic stress, however, localized fibrosis expands, eventually leading to cirrhosis, increased risk of liver cancer, and the need for a liver transplant in advanced cases.
The Evans lab discovered a genetic switch through which vitamin D-related ligands such as calcitriol, a hormonally active form of the vitamin, can put the brakes on fibrosis. "Preclinical results suggest the 'vitamin D brake' is highly efficacious and led us to believe that the time is right to consider a trial in the context of chronic liver disease," says Evans, a Howard Hughes Medical Institute Investigator and holder of the March of Dimes Chair in Molecular and Developmental Biology.
Previous studies have shown a physiologic role for vitamin D in liver function, but "it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis," says lead author Ning Ding, a research associate in the Gene Expression Laboratory.
"Current therapeutic approaches, which treat the symptoms of liver disease, don't stop liver fibrosis from progressing," says Michael Downes, a senior staff scientist in the Gene Expression Laboratory and co-corresponding author on the paper. "In liver diseases where the underlying cause cannot be cured, progression to cirrhosis is currently inevitable in some people. What we have discovered is that by acting on the genome, VDR can simultaneously defend against multiple fibrotic activators. This is important because many different pro-fibrotic signaling pathways converge on the genome to affect their fibrotic response."

flying_dutchman

The Salk discovery that calcipotriol counters the fibrotic response in stellate cells illuminates a potentially safer, more effective strategy capable of neutralizing multiple convergent fibrotic triggers.
The Salk scientists say that clinical trials of the vitamin D analog for the treatment of liver fibrosis are being planned. The synthetic vitamin D analog is better than natural vitamin D, they say, for a couple of reasons. First, natural vitamin D, which is found in small amounts in a few foods and produced in the body by exposure to sunlight, degrades quickly, while synthetic versions of vitamin D are less susceptible to breakdown. Second, too much natural vitamin D can cause hypercalcemia, or elevated calcium in the blood, which can lead to nausea and vomiting, frequent urination, muscle weakness and joint aches and pain. The synthetic vitamin D analog, on the other hand, produces a strong response without adding calcium to the blood.
In addition, the researchers say this new model for treating liver fibrosis may also be helpful in treating other diseases with a fibrotic component, including those of the lung, kidney and pancreas.
Other researchers on the study were Ruth T. Yu, Mara H. Sherman, Mathias Leblanc, Mingxiao He, Annette R. Atkins and Grant D. Barish, from the Salk Institute; Nanthakumar Subramaniam, Caroline Wilson, Renuka Rao, Sally Coulter and Christopher Liddle, of the University of Sydney (Australia); and Sue L. Lau , Christopher Scott and Jenny E. Gunton, of the Garvan Insitute for Medical Research (Australia).
The work was supported by grants from the National Institutes of Health, the Howard Hughes Medical Institute, the National Health and Medical Research Council of Australia, the Genentech Foundation, the Leona M. and Harry B. Helmsley Charitable Trust, the Samuel Waxman Cancer Research Foundation, Stand Up to Cancer and Ipsen/Biomeasure.

flying_dutchman

这个是science daily上面的新闻 ，总归是要可靠些， 说的是达力士软膏 可能能治肝硬化，就是不晓得要怎么用， 不知道挤一支夹火腿肠面包吃 管不管用~~

40更坚强

:有消息总比没消息好

xmobe

有希望就好