儿童乙型肝炎病毒基因型变化是密切相关e抗原/抗HBe血清转

StephenW

Source: J Pediatr Gastroenterol Nutri  |  Posted 4 days ago
Hepatitis B Virus Genotype Change In Children Is Closely Related to HBeAg/anti-HBe Seroconversion; Wirth S, Bortolotti F, Brunert C, Postberg J, Hensel K, Jenke A; Journal of Pediatric Gastroenterology and Nutrition (Apr 2013)


OBJECTIVES:: Genotype changes have been observed during long-term follow-up in adults with chronic hepatitis B virus (HBV) infection. The aim of this study was to assess the frequency and distribution of HBV genotype shifts in treated and untreated European children during the different phases of chronic hepatitis B. PATIENTS AND METHODS:: The initial population consisted of 85 HBeAg positive children who were sequentially investigated for HBV genotypes over a mean time period of 7.1 years. During the survey 65 patients seroconverted to anti-HBe and 24 received antiviral treatment. Genotyping was done by restriction fragment length polymorphism. RESULTS:: Genotypes at enrolment were distributed as follows: D (n = 67), A (n = 11), B (n = 4), C and mixed (n = 3). A genotype change was observed in 16 (19%) participants at last visit of whom 1/20 (5%) remained persistently HBeAg positive and 15/65 (23%) children had seroconverted to anti-HBe (p < 0.001). Genotype shift was: D to A or B in 9 individuals, A to D in 5, and A to B in one. Genotype changes were more frequent in untreated than in treated subjects; however, the difference was not statistically significant. CONCLUSION:: The results of this study suggest that genotype change is a relatively frequent event in children with chronic hepatitis B after anti-HBe seroconversion and independent of treatment. The reasons why only some patients will experience this event remain to be clarified.

StephenW

消息来源：J小儿胃肠营养|发表于4天前
儿童乙型肝炎病毒基因型变化是密切相关的e抗原/抗HBe血清转换;维尔特ŞF博尔托洛蒂，ÇBrunert，亨泽尔Postberg J，K表，Jenkeà儿科胃肠病学和营养学杂志（2013年4月）


目标::基因型变化已经在长期随访观察成人慢性乙型肝炎病毒（HBV）感染。这项研究的目的是评估的频率和分布处理和未处理的欧洲儿童乙肝病毒基因型的转变过程中不同阶段的慢性乙型肝炎患者和方法::初始种群包括HBeAg阳性儿童85人依次调查HBV基因型超过平均时间为7.1年。在调查过程中抗-HBe血清转换的患者65例，24接受抗病毒药物治疗。限制性片段长度多态性进行基因分型。结果显示：在入学的基因型分布如下：D组（n =67），A（N =11），B组（n =4），C和混合组（n =3）。 A基因型的变化中观察到16（19％）的参与者，在最后的访问时间，其中1/20（5％）持续HBeAg的血清阳转阳性和15/65（23％）的孩子们抗HBe（P <0.001）。基因型转变为：D为A或B在9个人中，A至D5，A到B的一个。在治疗的受试者比未经处理的基因型变化更频繁，但差异无统计学意义。结论：本研究结果表明，基因型变化是一个相对频繁的事件后抗-HBe血清转换和独立的治疗慢性乙型肝炎的儿童。有些病人会遇到此事件的原因仍有待澄清。