聚乙二醇干扰素治疗非活动性HBsAg携带者获得HBsAg清除者的CD4`

sddp1

还有一个问题是：hbv+hdv 毋庸置疑是加重的，hbv+hcv也应该是加重的，hbv+反复感冒病毒呢？

StephenW

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在这项研究中,最高的HBsAg水平约200 IU / ml. (86 +- 120 iu/ml)

sddp1

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如果200IU，那这个实验似乎是多余的了。
http://www.haodf.com/wenda/wangzhenyudoctor_g_695338054.htm?p=1
希望大家都是朋友，学习精髓。

sddp1

一共有1068台湾肝炎乙e抗原（HBeAg）阴性乙肝病毒携带者血清HBV DNA水平<2000 IU / mL的基线，随访的平均时间为13.0年。病人被分为HBsAg水平的基础上，HBsAg水平和发展HBeAg阴性肝炎，肝炎爆发，和肝硬化之间的关系进行了研究。
结果：1068低病毒载量的患者中，有280 HBeAg阴性肝炎，每年的发病率为2.0％。
http://www.hbvhbv.info/forum/thread-1204248-1-1.html

StephenW

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"如果200IU，那这个实验似乎是多余的了。" - 如果200IU, 许多人预测表面抗原（HBsAg）将清除, 但在什么时候？

StephenW

sddp1 发表于 2013-3-9 22:03
一共有1068台湾肝炎乙e抗原（HBeAg）阴性乙肝病毒携带者血清HBV DNA水平

请阅读以下:
J Dig Dis. 2013 Feb 21. doi: 10.1111/1751-2980.12051. [Epub ahead of print]
Hepatitis B "inactive carriers": Clinical course and outcomes.
Tong MJ, Trieu J.
Source

Liver Center, Huntington Medical Research Institutes, Pasadena; Pfleger Liver Institute and the Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Abstract
OBJECTIVE:

Hepatitis B "inactive carriers" are HBeAg-negative patients with normal alanine aminotransferase (ALT) values and undetectable to low levels of hepatitis B virus (HBV) DNA. We sought to determine the clinical impact of ALT and HBV DNA elevations which were observed during the course of HBV infection in these patients.
METHODS:

From January 1989 to January 2012, 146 HBsAg-positive "inactive carriers" were prospectively followed up in a community hospital clinic. Laboratory tests including ALT and HBV DNA measurements and hepatocellular carcinoma (HCC) surveillance were performed every 6-12 months.
RESULTS:

During a mean follow-up of 8.0 ± 6.3 years, 56 (38.3%) of 146 patients maintained ALT ≤40 U/L and HBV DNA ≤ 10 000 copies/mL. However, 39 (26.7%) had rises of ALT >40-80 U/L and 4 (2.7%) had ALT >80 U/L, all of which subsequently reverted to baseline values, except for one patient whose ALT and HBV DNA simultaneously elevated to 467 U/L and 15 400 000 copies/mL, respectively. Also, during follow-up, 69 (47.3%) "inactive carriers" had increases in HBV DNA >10 000-999 999 copies/mL. At the last follow-up visit, 38 of these patients' HBV DNA values had returned to baseline levels, while the remaining 31 patients had levels of HBV DNA between >10 000-999 999 copies/mL; in these latter patients, the corresponding ALT values were ≤40 U/L. Four liver-related outcomes were noted: 129 (88.3%) remained "inactive carriers", 13 (8.9%) had loss of HBsAg, 1 (0.7%) had spontaneous reactivation of HBV requiring antiviral therapy, and 2 (1.4%) developed HCC.
CONCLUSIONS:

Although the prognosis is favorable in "inactive carrier" patients, transient ALT and HBV DNA elevations may be observed during its clinical course but appears to have minimal significance. Also, continual surveillance remains necessary since the risk for HCC still exists.

1989年1月至2012年1月146例HBsAg阳性的“非活动性携带者”进行了前瞻性随访在社区医院诊所。实验室检查包括ALT和HBV DNA测定和肝细胞肝癌（HCC）监视每6-12个月进行。
结果：

在平均随访8.0±6.3年，146例中有56例（38.3％）保持ALT≤40 U / L，HBV DNA≤10 000拷贝/毫升。然而，有39例（26.7％）的ALT升高> 40〜80 U / L和4（2.7％）ALT> 80 U / L，随后恢复至基线值，除一名患者的ALT和HBV DNA同时升高到467 U / L和15 400 000拷贝/毫升，分别。另外，在随访过程中，69（47.3％），“非活动性携带者”的提高，在HBV DNA> 10 000-999 999拷贝/ ml。在最后的随访，这些患者的HBV DNA值38已恢复至基线水平，而余下的31例患者的HBV DNA水平在10 000-999 999拷贝/ ml之间，后者的患者，相应的ALT值分别为≤40 U / L。四肝脏相关的结果指出：129（88.3％）仍然是“非活动性携带者”，13（8.9％）损失的乙型肝炎表面抗原（HBsAg），1（0.7％），HBV自发激活需要抗病毒治疗，2（1.4％） HCC。
结论：

虽然预后良好，可观察到在“惰性载体”的病人，一过性ALT和HBV DNA升高其临床过程，但似乎有最小的意义。此外，持续的监测仍然是必要的，因为肝癌的风险仍然存在。

sddp1

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看来dna下降到阴性，肝功正常的小三是稳定的，风险较小的乙携。谢谢你的资料

sddp1

持续的监测仍然是必要的，因为肝癌的风险仍然存在。

StephenW

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" 在这项研究中,最高的HBsAg水平约200 IU / ml. " - 对不起，这是错误的. 120是标准偏差
(86 +- 120 iu/ml). 最高的HBsAg水平约未知.

sddp1

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非常感谢！如果能耐受ifn的副作用，我也想参加类似的实验。