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J Hepatol. <http://www.ncbi.nlm.nih.gov/pubmed/> 2013 Jan 29. pii: S0168-8278(13)00076-7. doi: 10.1016/j.jhep.2013.01.029. [Epub ahead of print]
Serum Levels Of Interferon Gamma-Inducible Protein-10 And Response To Peginterferon Therapy In Hbeag-Positive Chronic Hepatitis B.
Sonneveld MJ, Arends P, Boonstra A, Hansen BE, Janssen HL
Source
Departments of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Abstract
BACKGROUND & AIMS:
Serum levels of interferon-gamma inducible protein 10 (IP-10) are a marker for immune activity, and may predict response to peginterferon (PEG-IFN) therapy in chronic hepatitis B.
METHODS:
IP-10 was measured at baseline and on-treatment week 12 in 210 HBeAg- positive patients treated with PEG-IFN for 52 weeks. Response to treatment was assessed at 6 months post-treatment and defined as HBeAg loss, combined response (HBeAg loss with HBV DNA<10,000c/mL) or HBsAg loss.
RESULTS:
Median baseline IP-10 levels were 158 pg/mL. Higher baseline IP-10 was associated with more HBV DNA, HBeAg and HBsAg decline from week 4 onwards, and IP-10 was higher in patients who achieved HBeAg loss(p=0.001) and combined response (p=0.052). A combination of high IP-10 (>150pg/mL) with absence of precore (PC) and core promoter (BCP) mutants strongly predicted combined response and HBsAg loss: 48% of patients with high IP-10 and no detectable mutants achieved a combined response (p<0.001). A minimal non-significant decline from baseline was observed to week 12 (0.015 log pg/mL,p=0.52 compared to baseline), but decline was somewhat more pronounced in patients who achieved HBeAg loss (0.05 log pg/mL, versus an increase of 0.05 in patients without HBeAg loss,p=0.04).
CONCLUSIONS:
Higher pre-treatment IP-10 levels are associated with an increased probability of HBeAg loss after PEG-IFN therapy. A combination of high baseline IP-10 and absence of PC and BCP mutants identified patients with the highest probability of combined response and HBsAg loss. There appears little use for on-treatment quantification of IP-10 for prediction of response to PEG-IFN.
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