B肝炎C基因型增加肝癌风险

StephenW

Hepatitis B genotype C linked to increased hepatoma risk

Last Updated: 2013-01-25 17:25:09 -0400 (Reuters Health)

By Will Boggs, MD

NEW YORK (Reuters Health) - Of all the major hepatitis B virus (HBV) genotypes, genotype C carries the highest risk for hepatocellular carcinoma (HCC), Chinese researchers say.

"These findings are useful when we decide the need of antiviral therapy and intensity of HCC surveillance," Dr. Grace L.-H. Wong from The Chinese University of Hong Kong told Reuters Health. "The treatment threshold for patients infected by genotype C HBV should be probably lower than (for) those infected by other genotypes. Also patients infected by genotype C HBV should have more frequent HCC screening tests."

As reported online January 10 in Alimentary Pharmacology and Therapeutics, Dr. Wong and colleagues used a meta-analysis of 43 studies involving 14,545 patients to investigate the relative risk of HCC among the four major HBV genotypes (A, B, C, and D).

In the 33 studies with data on patients with genotypes B and C, HCC occurred about twice as often with genotype C HBV as with genotype B HBV (25% vs 13%; p<0.001).

HCC rates did not differ significantly between genotypes A and D (14% vs 11%; p=0.71), in the 12 studies that compared them.

Ten studies included patients with genotypes A and/or D and genotype C. In these, HCC rates were significantly higher with genotype C (30% vs 7%; p<0.001).

In eight studies, there was no significant difference in HCC risk between subgenotypes Ce and Cs (41% vs 28%; p =0.54).

StephenW

最后更新：2013年1月25日17点25分09秒-0400（路透社医学新闻）

由Will博格斯，MD

NEW YORK（路透社医学新闻） - 所有主要的乙肝病毒（HBV）基因型，C基因型进行肝细胞肝癌（HCC）的风险最高，中国的研究人员说。

“这些发现非常有用，当我们决定需要抗病毒治疗和强度的HCC监测，”格蕾丝博士林丽华黄从香港大学中国对路透社记者说。 “C基因型HBV感染患者的治疗阈值应低于（）其他基因型感染者的可能。C基因型HBV感染的患者也应该有更频繁的肝癌筛查试验。”

据报道1月10日在网上消化系统药理学和治疗学，王博士和他的同事使用了荟萃分析的43项研究进行了分析，涉及14,545的相对危险性肝癌患者进行调查，在四个主要的HBV基因型（A，B，C，D） 。

B和C基因型的患者在33项研究的数据，HCC发生的两倍，经常与C基因型HBV B基因型（25％比13％，P<0.001）。

HCC率不基因型A和D（14％对11％，P =0.71）之间，在12项研究，比较他们。

10个研究包括患者基因型A和/或在这些D和C基因型，HCC率显着高于C基因型（30％对7％，P <0.001）。

在8个研究中，有肝癌风险之间的亚型CE和CS（41％对28％，P = 0.54）无显着差异。

疯一点好

中国可能是c型的多呢，国内哪里可以检测乙肝基因型，不过即使检测出不好了又有什么办法呢？

sddp1

感染hbv就已经是高危人群了，再讨论基因型意义不大了，及时检查才是关键。依稀记得台湾的高金素梅就是及时发现hcc治愈的

MP4

疯一点好 发表于 2013-2-3 23:19
中国可能是c型的多呢，国内哪里可以检测乙肝基因型，不过即使检测出不好了又有什么办法呢？ ...

中国B和C型比较多。
有些耐药检测会顺道写上基因型。
这意味着查出是C基因型的治疗上要更积极点。

疯一点好

哎，就现在这样子都难控抑郁焦虑心态，每天惶惶不可终日的，查出来是C型也没办法啊，反正该抗的也抗了，该查的也查了，听天由命吧。