乙肝病毒表面抗原（HBsAg）阳性和HBsAg阴性B型肝炎病毒感染的

StephenW

http://cvi.asm.org/content/20/2/269.abstract?etoc
Hepatitis B Virus Surface Antigen (HBsAg)-Positive and HBsAg-Negative Hepatitis B Virus Infection among Mother-Teenager Pairs 13 Years after Neonatal Hepatitis B Virus Vaccination

    Qing-Qing Yao a,
    Xiao-Lian Dong b,
    Xue-Cai Wang b,
    Sheng-Xiang Ge c,
    An-Qun Hu d,
    Hai-Yan Liu d,
    Yueping Alex Wang e,
    Quan Yuan c
    Ying-Jie Zheng a

+ Author Affiliations

    a Department of Epidemiology, School of Public Health, the Key Laboratory on Public Health Safety, Ministry of Education, Fudan University, Shanghai, China
    b Center for Disease Control and Prevention of Deqing County, Huzhou, Zhejiang Province, China
    c National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian Province, China
    d Anqing City Hospital, Anqing, Anhui Province, China
    e Perinatal & Reproductive Epidemiology Research Unit, School of Women's and Children's Health, the University of New South Wales, Sydney, Australia

ABSTRACT

It is unclear whether a mother who is negative for hepatitis B virus surface antigen (HBsAg) but positive for hepatitis B virus (HBV) is at potential risk for mother-to-child transmission of HBV. This study, using a paired mother-teenager population, aimed to assess whether maternal HBsAg-negative HBV infection (hnHBI) is a significant source of child HBV infection (HBI). A follow-up study with blood collection has been conducted on the 93 mother-teenager pairs from the initial 135 pregnant woman-newborn pairs 13 years after neonatal HBV vaccination. Serological and viral markers of HBV have been tested, and phylogenetic analysis of HBV isolates has been done. The HBI prevalence was 1.9% (1 hnHBI/53) for teenage children of non-HBI mothers, compared with 16.7% (1 hnHBI/6) for those of hnHBI mothers and 2.9% (1 HBsAg-positive HBV infection [hpHBI]/34) for those of hpHBI mothers. Similar viral sequences have been found in one pair of whom both the mother and teenager have had hnHBI. In comparison with the hpHBI cases, those with hnHBI had a lower level of HBV load and a higher proportion of genotype-C strains, which were accompanied by differentiated mutations (Q129R, K141E, and Y161N) of the “a” determinant of the HBV surface gene. Our findings suggest that mother-to-teenager transmission of hnHBI can occur among those in the neonatal HBV vaccination program.

StephenW

摘要

目前还不清楚谁是B型肝炎病毒表面抗原（HBsAg）阴性，但B型肝炎病毒（HBV）阳性的母亲是在母亲对HBV母婴传播的潜在风险。这项研究中，使用配对的母亲小将人口的，目的是评估是否产妇HBsAg阴性HBV感染（hnHBI）的儿童乙肝病毒感染（HBI）是一个重要的来源。采血的后续研究，已进行13年后，从最初的135个孕妇，新生儿对母亲小将的93对新生儿乙肝疫苗接种。 HBV血清学和病毒标志物已经过测试，已经做了和乙肝病毒分离株的系统发育分析。 HBI患病率为1.9％，为十几岁的孩子非HBI的母亲（1 hnHBI/53），相比（1/6 hnHBI）对于那些hnHBI母亲的16.7％和2.9％（1乙肝表面抗原阳性的乙肝病毒感染hpHBI] / 34）对于那些hpHBI母亲的。类似的病毒序列已经发现了一种对人的母亲和十几岁的已经有hnHBI的。以比较，与hpHBI例的，那些有hnHBI的一个较低的水平的HBV负荷和基因型C型菌株的比例较高，这是伴随着区别的突变（Q129R，K141E，Y161N）的“a”决定的HBV表面基因。我们的研究结果表明，母亲小将的hnHBI传输可以发生在新生儿乙肝疫苗接种程序中。