平均血小板体积确定在慢性乙型肝炎患者的肝纤维化或炎症

StephenW

http://www.docguide.com/can-mean-platelet-volume-determine-severity-liver-fibrosis-or-inflammation-patients-chronic-hepatiti?hash=c8431e6c&eid=30702&alrhash=2f4244-e14fac0ff7ef1d5b0c78458126191858
Source: Eur J Gastroenterol Hepatol  |  Posted 3 days ago
Can mean platelet volume determine the severity of liver fibrosis or inflammation in patients with chronic hepatitis B?
Ceylan B, Fincanci M, Yardimci C, Eren G, Tözalgan U, Müderrisoglu C, Pasaoglu E; European Journal of Gastroenterology and Hepatology (Jan 2013)

  
AIMS: We aimed to determine whether mean platelet volume (MPV) is one of the variables that determine the severity of liver fibrosis and inflammation. MATERIALS AND METHODS: Patients with chronic hepatitis B virus (HBV) infection were divided into two groups: patients with fibrosis scores of 0-3 and 4-6 and patients with histologic activity index scores of 0-9 and 10-18 (according to the Ishak Scoring System). The independent variables determining the severity of liver fibrosis and inflammation were investigated. RESULTS: Two hundred and thirty-eight patients were included in this retrospective study. The fibrosis scores of 29 patients (12.2%) were higher than 3. The independent variables that determined the severity of the fibrosis score were a high level of serum γ-glutamyl transferase and a low blood platelet count (odds ratio and P values were 1.016 and 0.004 for γ-glutamyl transferase, and 0.986 and 0.002 for blood platelet count). The histologic activity indexes of 38 patients (16%) were higher than 9. The independent variables determining the severity of liver inflammation were serum HBV DNA, γ-glutamyl transferase, and globulin levels and the MPV [odds ratio and P values were, respectively, 0.1001 and 0.046 for HBV DNA (×10); 1.016 and 0.004 for γ-glutamyl transferase; 2.247 and 0.039 for globulin; and 1.488 and 0.004 for the MPV]. The sensitivity, specificity, and positive predictive value and negative predictive value of the model predicting the severity of liver inflammation were 60.5, 83, 40.3, and 91.7%, respectively (area under the receiver-operating characteristic curve=0.775, P=0.0001). CONCLUSION: MPV may provide useful information to predict the degree of liver inflammation along with other markers.

StephenW

目的：我们的目的，以确定平均血小板体积（MPV）是否是确定肝纤维化和炎症的严重程度的变量之一。材料与方法：慢性乙型肝炎病毒（HBV）感染的患者分为两组：纤维化评分为0-3和4-6的患者和患者组织学活动性指数评分（0-9和10-18伊沙克评分系统）。独立的变量，确定肝纤维化和炎症的严重程度进行了调查。结果：两百年和38例患者被纳入这项回顾性研究。纤维化评分为29例（12.2％）均高于3。的独立变量，确定的严重程度的纤维化评分分别为高血清γ-谷氨酰转移酶水平的和一个低的血小板计数（比值比和P值分别为γ-谷氨酰转移酶1.016和0.004，0.986和0.002血小板计）。 38例（16％）的组织学活动性指标均高于9。独立变量，确定肝脏炎症的严重程度，血清HBV DNA，γ-谷氨酰转移酶，球蛋白水平和MPV [比值比，P值，分别为0.1001和0.046 HBV DNA（×10）; 1.016和0.004 γ-谷氨酰转移酶，2.247和0.039球蛋白; 1.488和0.004的MPV。的敏感性，特异性，阳性预测值和阴性预测值的模型预测肝脏炎症的严重程度分别为60.5，83，40.3，和91.7％，分别为（接收器工作特性曲线下面积= 0.775，P = 0.0001） 。结论：MPV可以提供有用的信息来预测以及与其他标志物，肝组织炎症程度。

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斯蒂芬很勤奋，但是文章翻译太差，无法看懂，感慨