宿主遗传因素影响慢性乙型肝炎患者的自发性HBsAg血清清除

StephenW

PLoS One. <http://www.ncbi.nlm.nih.gov/pubmed/&gt; 2013;8(1):e53008. doi: 10.1371/journal.pone.0053008. Epub 2013 Jan 11.

Host Genetic Factors Affecting Spontaneous HBsAg Seroclearance in Chronic Hepatitis B Patients.

Cheng HR, Liu CJ, Tseng TC, Su TH, Yang HI, Chen CJ, Kao JH

Source

Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan.

Abstract

Spontaneous clearance of hepatitis B surface antigen (HBsAg) in chronic hepatitis B (CHB) patients usually indicates a remission of hepatitis activity and a favorable outcome. Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection. However, little is known about the impact of these 2 SNPs on spontaneous HBsAg clearance in CHB patients. In this case-control study, a total of 100 male HBeAg-negative chronic HBV carriers who cleared HBsAg spontaneously (case group) and 100 age-matched HBeAg-negative male patients with persistent HBsAg positivity (control group) were enrolled. We investigated the relationship between these 2 SNPs and HBsAg clearance. There was a higher frequency of rs9277535 non-GG genotype in the case group (57% vs. 42%). Patients with rs9277535 non-GG genotype had a higher chance to clear HBsAg [Odds ratio (OR): 1.83, 95% confidence interval (CI): 1.04?3.21, P = 0.034]. Compared to GG haplotype of rs3077 and rs9277535, GA haplotype had a higher chance of achieving spontaneous HBsAg loss (OR: 2.17, 95% CI: 1.14?4.16, P = 0.030). In conclusion, rs9277535 non-GG genotype is associated with a higher likelihood of spontaneous HBsAg seroclearance in CHB patients.

StephenW

临床医学研究所，国立台湾大学，台北，台湾。


B型肝炎表面抗原（HBsAg）在慢性乙型肝炎（CHB）患者自发清除通常表示一个缓解肝炎活动和有利的结果。两个单核苷酸多态性（SNP），rs3077附近HLA-DPA1地区和附近HLA-DPB1地区的rs9277535，已被证明是与HBV持久性急性HBV感染后。然而，鲜为人知的是，这2个单核苷酸多态性对慢性乙型肝炎患者的自发HBsAg清除的影响。在这种情况下，对照研究，共招收100名HBeAg阴性慢性乙肝病毒携带者的乙肝表面抗原自发清除（病例组）和100例年龄匹配的HBeAg阴性的男性患者，持续性乙肝表面抗原阳性（对照组）。我们研究了这2个SNP位点和HBsAg清除之间的关系。有rs9277535非GG基因型在病例组（57％对42％）更高的频率。与rs9277535非GG基因型的患者有较高的机会，以清除乙肝表面抗原[比值比（OR）：1.83，95％可信区间（CI）：1.04 3.21，P = 0.034]。 rs3077和rs9277535的GG单体型相比，GA单倍型有较高的机会，实现自发HBsAg消失（OR：2.17，95％CI：1.14？4.16，P = 0.030）。总之，rs9277535非GG基因型与自发的慢性乙型肝炎患者乙肝表面抗原转阴的可能性更高。

MP4

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