垂直传播免疫预防失败的风险因素

StephenW

J Infect. 2012 Dec 31. pii: S0163-4453(12)00389-1. doi:
10.1016/j.jinf.2012.12.008. [Epub ahead of print]

Identification of risk factors associated with immunoprophylaxis failure to
prevent the vertical transmission of hepatitis B virus.

有关的风险因素的识别与免疫预防失败
预防B型肝炎病毒的垂直传播。
Yin Y, Wu L, Zhang J, Zhou J, Zhang P, Hou H.

Source

Department of Obstetrics and Gynaecology, the Third Affiliated Hospital of
Sun Yat-Sen University, Guangzhou, China. Electronic address:
[email protected].

Abstract

OBJECTIVE:

To determine the potential risk factors associated with the
immunoprophylaxis failure to prevent hepatitis B virus (HBV) vertical
transmission.

METHODS:

A total of 1360 newborn infants from HBsAg(+) women were included. Some
pregnant women were vaccinated with anti-HBs immunoglobulins (HBIG) monthly
for three months beginning at 7 months post pregnancy. All newborns
received HBIG injection immediately after birth and were vaccinated with
recombinant hepatitis B vaccine. Neonates were followed up for one year and
their HBV-related parameters were tested longitudinally.

RESULTS:

There were 21 cases (1.54%) with immunoprophylaxis failure (HBsAg(+) and/or
HBV DNA(+) in 12-month old). Infants with immunoprophylaxis failure were
associated with HBeAg(+) or HBV DNA(+) in their mother, particularly for
those with high titers (≥10(7) IU/ml) of HBV DNA. The HBV vertical
transmission rates in those infants were associated with feeding modes, but
not with the HBIG vaccination in their mothers or delivery method of these
babies. Serum HBeAg(+) (RR, 31.740; 95%CI, 3.884-259.381; p < 0.001) and
HBV DNA ≥10(7) IU/ml in pregnant women (RR, 22.583; 95%CI, 4.749-107.397;
p < 0.000) after adjusted other tested factors were independent risk
factors of the immunoprophylaxis failure in infants.

CONCLUSIONS:

Our results suggest that maternal serum HBeAg(+) and high HBV load are
potential predictors of immunoprophylaxis failure to prevent HBV vertical
transmission.

StephenW

Ĵ感染。 2012年12月31日。 PII：S0163-4453（12）00389-1。 DOI：
10.1016/j.jinf.2012.12.008。 [EPUB的提前打印]

有关的风险因素的识别与免疫预防失败
预防B型肝炎病毒的垂直传播。

吴尹Y，L，张健，周军，张P，侯H.

源

附属第三医院妇产科，
孙中山大学，广州，中国。电子地址：
[email protected]。

抽象

目的：

为了确定潜在的风险因素与
预防乙型肝炎病毒（HBV）垂直的免疫预防失败
传输。

方法：

新生儿乙肝表面抗原（+），共有1360名妇女。一些
孕妇接种了疫苗的抗-HBs免疫球蛋白（HBIG）每月
三个月，开始在7个月后怀孕。所有新生儿
收到出生后立即注射HBIG和接种疫苗
重组乙肝疫苗。新生儿随访一年，
纵向HBV相关参数进行了测试。

结果：

有21例（1.54％），与免疫预防故障（HBsAg的（+）和/或
HBV DNA（+），12个月大）。婴幼儿免疫预防失败
与HBeAg（+）或HBV DNA（+），他们的母亲，特别是对
那些具有高滴度（≥10（7）IU/毫升）的HBV DNA。 HBV垂直
传输速率在这些婴儿的喂养方式，但
不与他们的母亲或交付方法，这些乙肝免疫球蛋白接种疫苗
婴儿。血清HBeAg（+）（RR，31.740，95％CI，3.884-259.381，P <0.001）和
HBV DNA≥10 IU / ml的孕妇（7）（RR，22.583，95％CI，4.749-107.397;
P <0.000），其他测试因素调整后的独立危险
在婴儿的免疫预防失败的因素。

结论：

我们的研究结果表明，母体血清HBeAg（+）和高病毒负荷
免疫预防失败，以防止乙肝病毒垂直的潜在预测
传输。

咬牙硬挺

母乳喂养不要紧喽？

MP4

咬牙硬挺 发表于 2013-1-23 08:53
母乳喂养不要紧喽？

母乳喂养可以的