慢性乙肝病毒感染的孕妇和她们的婴儿在中国沉阳

StephenW

http://www.virologyj.com/content/10/1/17/abstract
Chronic HBV infection among pregnant women and their infants in Shenyang, China                              

Yang Ding, Qiuju Sheng, Li Ma and Xiaoguang Dou        

Virology Journal 2013, 10:17 doi:10.1186/1743-422X-10-17
Published: 7 January 2013                        
Abstract (provisional)Background

The main transmission route of the hepatitis B virus (HBV) is mother to child transmission   and contributes significantly to chronic HBV infection. Even though immunoprophylaxis   with hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine is administrated to   neonates whose mothers are hepatitis B surface antigen (HBsAg) positive, about 10%   of the neonates suffer from HBV infection in their early life.

Objectives

To survey chronic HBV infection among pregnant women and their infants and analyze   the reason for immunoprophylaxis failure.

Methods

Serum HBsAg was tested in all pregnant women. HBVDNA and other serum HBV markers including   hepatitis B e antigen (HBeAg), hepatitis B core antibody (anti-HBc) and hepatitis   B surface antibody (anti-HBs) were tested among HBsAg positive pregnant women. All   infants whose mothers were HBsAg positive were vaccinated with a standard immunoprophylaxis.   Serum HBV markers and HBVDNA were tested among these infants at 7 months of age. HBV   genotypes were analyzed among the infants and pregnant women who were HBVDNA positive.

Results

The prevalence of HBsAg, anti-HBc and anti-HBs among 4,536 pregnant women was 5.49%,   29.65% and 58.55%, respectively. The prevalence of HBsAg, anti-HBc and anti-HBs among   pregnant women older than 20 years of age was significantly different compared to   pregnant women younger than 20 years of age (4.54, 5.69 and 0.61 times, prevalence   older vs. younger, respectively. P<0.05, 0.01, 0.05, respectively).Among 249 HBsAg   positive pregnant women, 167 (67.07%) were HBeAg positive, 204 (81.93%) were HBVDNA   positive and only 37 (14.86%) had HBVDNA >107 IU/ml. Among the infants whose mothers   were HBsAg positive, 214 (85.94%) infants were anti-HBs positive. There were 12 (4.82%)   infants who were HBsAg and HBVDNA positive, and all 12 of these infants mothers were   HBeAg positive and had HBVDNA >107 IU/ml. Genotypes B and C were present among 165   pregnant women and genotype C was present in 85 pregnant women. There were 12 infants   who were HBsAg positive and had the same HBV genotypes as their mothers. There was   a significant difference in genotypes between the pregnant women whose infants were   infected with HBV compared to those without HBV infection (P < 0.05).

Conclusions

There was a significant decline in HBsAg prevalence among pregnant women and their  infants in Shenyang. Genotype C might be a risk factor for mother to child transmission   of HBV.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.         

StephenW

慢性乙肝病毒感染的孕妇和她们的婴儿在中国沉阳

秋菊盛，杨丁，李马,晓光窦

2013年病毒学杂志，10:17 DOI：10.1186/1743-422X-10-17
发布时间：2013年1月7日
摘要（临时）
背景

B型肝炎病毒（HBV）的主要传播途径是母婴传播，并有助于显着的慢性HBV感染。即使乙肝免疫球蛋白（HBIG）和乙肝疫苗的免疫预防给药给新生儿的母亲是乙肝表面抗原（HBsAg）阳性的新生儿中，约有10％在其早期生活中遭受乙肝病毒感染。
目标

调查慢性乙肝病毒感染的孕妇和她们的婴儿和分析免疫预防故障的原因。
方法

在所有孕妇血清HBsAg进行了测试。 HBVDNA和血清HBV标志物，包括B型肝炎e抗原（HBeAg），乙肝核心抗体（抗-HBc）和乙肝表面抗体（抗​​-HBs）之间HBsAg阳性孕妇进行了测试。所有婴儿的母亲HBsAg阳性标准的免疫预防接种。在这些婴儿在7个月的年龄，血清HBV标志物和HBVDNA进行了测试。谁是HBVDNA阳性的婴儿和孕妇中HBV基因型进行了分析。
结果

在4536个孕妇HBsAg，抗-HBc和抗-HBs的患病率分别为5.49％，29.65％和58.55％。年龄20岁以上的孕妇中是显着不同的HBsAg，抗-HBc和抗-HBs的患病率相比，怀孕的妇女年龄小于20岁（4.54，5.69和0.61倍，患病率分别为年长与年轻，。 P <0.05，0.01，0.05，分别），其中249例HBsAg阳性的孕妇中，有167人（67.07％）为HBeAg阳性，204（81.93％），HBVDNA阳性，只有37（14.86％），HBVDNA> 107 IU /毫升。在HBsAg阳性的婴儿的母亲中，有214（85.94％），婴儿抗-HBs阳性。有12个（4.82％）的婴儿HBsAg和HBVDNA阳性，所有12个这些婴儿的母亲HBeAg阳性，HBVDNA> 107 IU / ml的。基因型B和C在165个怀孕妇女和C基因型为85名孕妇在。有12名HBsAg阳性的婴儿和他们的母亲有同样的HBV基因型。有一个显着的差异基因型之间的孕妇，其婴儿感染HBV较无HBV感染者（P <0.05）。
结论

在HBsAg流行率的孕妇和她们的婴儿在沈阳是一个显着的下降。 C基因型可能是一个母亲HBV母婴传播的危险因素。
完整的文章可以作为一个临时的PDF。在生产中完全格式化的PDF和HTML版本。