重度饮酒会增加肝癌的发病率在乙肝病毒相关性肝硬化患者

StephenW

重度饮酒会增加肝癌的发病率在乙肝病毒相关性肝硬化
Source: J Hepatol  |  Posted 4 days ago
Heavy alcohol consumption increases the incidence of hepatocellular carcinoma in hepatitis B virus-related cirrhosis; Lin CW, Lin CC, Mo LR, Chang CY, Perng DS, Hsu CC, Lo GH, Chen YS, Yen YC, Hu JT, Yu ML, Lee PH, Lin JT, Yang SS; Journal of Hepatology (Dec 2012)


BACKGROUND&AIMS: Taiwan has a high prevalence of hepatitis B viral(HBV)infection and hepatocellular carcinoma (HCC) with increasing consumption of alcohol. We investigated the impact of heavy alcohol consumption and HBV infection on HCC in cirrhotic patients. METHODS: 966 cirrhotic patients (132 patients with HBV infection and alcoholism, 632 patients with HBV infection, and 202 patients with alcoholism) between 2000 and 2009 were enrolled and followed until 2011. The primary end-point was newly developed HCC. RESULTS: Within the three patient groups respectively-cirrhotic patients with HBV infection and alcoholism, HBV infection, and alcoholism-38 (28.8%), 100 (15.8%), and 21 (10.4%) showed newly developed HCC. The 10-year cumulative incidence (52.8% vs. 39.8% vs. 25.6%, P<0.001) and annual incidence (9.9%, 4.1%, and 2.1%) of HCC were significantly higher in cirrhotic patients with HBV infection and alcoholism than those with HBV infection or those with alcoholism. For patients with HBV infection and alcoholism, baseline serum HBV DNA (OR = 16.8, P=0.025), antiviral nucleos(t)ides analogues (NUCs) therapy (OR=0.01, P=0.035), and serum α-fetoprotein (OR=1.18, P=0.045) were risk predictors for HCC by multivariate logistic regression models. The cumulative incidence of HCC was higher in patients with higher baseline serum HBV DNA. Antiviral NUCs therapy reduced the incidence of HCC.
CONCLUSIONS: Heavy alcohol consumption significantly increased the risk of HCC in HBV-related cirrhotic patients. Elevated baseline serum HBV DNA was a strong risk predictor of HCC and antiviral NUCs therapy reduced the incidence of HCC in cirrhotic patients with HBV infection and alcoholism.

StephenW

资料来源：J肝脏病杂志|发表于4天前
重度饮酒会增加肝癌的发病率在乙肝病毒相关性肝硬化
林，陈，许鹏DS张CY，莫LR，林CC，CC，罗GH YS，YC日元，胡JT，于ML CW，李PH，林JT，杨SS中华肝脏病杂志（2012年12月）

   
背景与目的：台湾具有较高的乙肝病毒（HBV）感染与肝细胞癌（HCC）的发生率增加酒精的消费。我们调查的影响，重度饮酒与HBV感染对肝癌的肝硬化患者。方法：966例肝硬化患者（132例HBV感染，酗酒，与HBV感染632例，202例酗酒）进行了登记，并在2000年和2009年之后，直到2011年。主要终点是新开发的HCC。结果：在三个病人组分别肝硬化患者HBV感染，酗酒，HBV感染，酒精中毒38例（28.8％），100人（15.8％），和21（10.4％），表明新开发的HCC。 10年累计发生率（52.8％比39.8％比25.6％，P <0.001）和年度的HCC发生率（9.9％，4.1％和2.1％），显着高于肝硬化患者的HBV感染与酗酒比与HBV感染或那些有酗酒。与乙肝病毒感染，酗酒，基线血清HBV DNA（OR = 16.8，P = 0.025），抗病毒核苷（酸）集成开发环境的类似物（NUCs）治疗的患者（OR = 0.01，P = 0.035）和血清α-胎儿蛋白（OR = 1.18，P = 0.045），多因素logistic回归模型的预测为HCC的危险。累计肝癌的发病率较高，具有较高的基线血清HBV DNA的患者。抗病毒NUCs治疗肝癌的发病率降低。结论：在HBV相关的肝硬化患者，酗酒消费显着增加肝癌的危险。升高的基线血清HBV DNA是一个强大的风险预测的HCC和抗病毒药物NUCs的治疗肝癌的发病率降低肝硬化患者的HBV感染与酗酒。

重肝过后

我靠，10年累计发生率52％