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[感谢恭 Christine Kukka提供参考]
Int J Infect Dis. 2012 Nov 12. pii: S1201-9712(12)01248-9. doi: 10.1016/j.ijid.2012.09.002. [Epub ahead of print]
Is hepatitis B virus transmitted via the male germ line? A seroepidemiological study in fetuses.
Cai QX, Zhu YY.
Source
Department of Obstetrics and Gynecology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai City, China.
Abstract
OBJECTIVES:
To detect father-to-fetus transmission of hepatitis B virus (HBV) in utero.
METHODS:
We conducted a study at the prenatal diagnosis center of Taizhou City. Fetuses with one or both parents carrying the hepatitis B surface antigen (HBsAg) were identified before genetic testing during the period 2008-2010. Intrauterine samples were obtained by amniocentesis or cordocentesis and tested for serological markers and by quantitative DNA assays. All neonates received combined hepatitis B immunoprophylaxis after delivery, and serological follow-up tests were performed at 1 year of age.
RESULTS:
Of the 407 couples enrolled in the study, HBV was carried by fathers only in 164, and none of their fetuses were found to be HBV DNA-positive in utero. All fetal serological markers were found to be of maternal but not paternal origin. The response rate to postnatal vaccination was 98.6%, and none of the children who failed immunoprophylaxis were the offspring of the HBV carrier fathers.
CONCLUSIONS:
The infection of fetuses with HBV from the spermatozoa of carrier fathers seems unlikely, especially in an area where pre-conception hepatitis B vaccination is routinely provided.
Copyright © 2012 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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