维生素D有益的作用在病毒性肝炎的理论基础

StephenW

http://www.ncbi.nlm.nih.gov/pubmed/23082050
World J Gastroenterol. 2012 Oct 14;18(38):5338-50. doi: 10.3748/wjg.v18.i38.5338.
Theoretical basis of a beneficial role for vitamin D in viral hepatitis.L Ng KV, Nguyễn LT.
SourceKhanh vinh quốc Lương, Lan Thi Hoàng Nguyễn, Vietnamese American Medical Research Foundation, Westminster, CA 92683, United States.

AbstractAbnormal bone metabolism and dysfunction of the calcium-parathyroid hormone-vitamin D axis have been reported in patients with viral hepatitis. Some studies suggested a relationship between vitamin D and viral hepatitis. Genetic studies have provided an opportunity to identify the proteins that link vitamin D to the pathology of viral hepatitis (i.e., the major histocompatibility complex class II molecules, the vitamin D receptor, cytochrome P(450), the renin-angiotensin system, apolipoprotein E, liver X receptor, toll-like receptor, and the proteins regulated by the Sp1 promoter gene). Vitamin D also exerts its effects on viral hepatitis via non-genomic factors, i.e., matrix metalloproteinase, endothelial vascular growth factor, prostaglandins, cyclooxygenase-2, and oxidative stress. In conclusion, vitamin D could have a beneficial role in viral hepatitis. Calcitriol is best used for viral hepatitis because it is the active form of the vitamin D(3) metabolite.


   世界胃肠病学杂志。2012年10月14日，18（38）:5338-50。 DOI：10.3748/wjg.v18.i38.5338。
维生素D有益的作用在病毒性肝炎的理论基础。
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富国良庆永兰，阮氏晃，越南美国医学研究基金会，威斯敏斯特，CA 92683，美国。



钙的甲状旁腺激素，维生素D轴的骨代谢异常和功能障碍已报道病毒性肝炎患者。一些研究表明维生素D和病毒性肝炎之间的关系。遗传研究提供了一个机会来确定蛋白质的链接维生素D的病理肝炎病毒（即主要组织相容性复合体Ⅱ类分子，维生素D受体，细胞色素P（450），肾素 - 血管紧张素系统，载脂蛋白E ，肝脏X受体，Toll样受体和SP1基因启动子调控的蛋白质）。维生素D还发挥其对病毒性肝炎通过非基因组的因素，即，基质金属蛋白酶，血管内皮细胞生长因子，前列腺素，环氧合酶-2，和氧化应激。总之，维生素D可能会产生有益的作用在病毒性肝炎。骨化三醇是最好的，因为它是用于病毒性肝炎的维生素D（3）代谢物的活性形式。

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