由于最近接种疫苗 B型肝炎表面抗原检查阳性

StephenW

http://sciencealerts.com/stories/2014046/Positive_hepatitis_B_surface_antigen_tests_due_to_recent_vaccination_a_persistent_problem.html#.UG0OnaDpURN
Positive hepatitis B surface antigen tests due to recent vaccination: a persistent problem
由于最近接种疫苗B型肝炎表面抗原检查阳性
Hepatitis B virus (HBV) is a common cause of viral hepatitis with significant health complications including cirrhosis and hepatocellular carcinoma. Assays for hepatitis B surface antigen (HBsAg) are the most frequently used tests to detect HBV infection. Vaccination for HBV can produce transiently detectable levels of HBsAg in patients. However, the time course and duration of this effect is unclear. The objective of this retrospective study was to clarify the frequency and duration of transient HBsAg positivity following vaccination against HBV. The electronic medical record at an academic tertiary care medical center was searched to identify all orders for HBsAg within a 17 month time period. Detailed chart review was performed to identify all patients who were administered HBV vaccine within 180 days prior to HBsAg testing and also to ascertain likely cause of weakly positive (grayzone) results. During the 17 month study period, 11,719 HBsAg tests were ordered on 9,930 patients. There were 34 tests performed on 34 patients who received HBV vaccine 14 days or less prior to HBsAg testing. Of these 34 patients, 11 had grayzone results for HBsAg that could be attributed to recent vaccination. Ten of the 11 patients were renal dialysis patients who were receiving HBsAg testing as part of routine and ongoing monitoring. Beyond 14 days, there were no reactive or grayzone HBsAg tests that could be attributed to recent HBV vaccination. HBsAg results reached a peak COI two to three days following vaccination before decaying. Further analysis of all the grayzone results within the 17 month study period (43 results out of 11,719 tests) revealed that only 4 of 43 were the result of true HBV infection as verified by confirmatory testing. Our study confirms that transient HBsAg positivity can occur in patients following HBV vaccination. The results suggest this positivity is unlikely to persist beyond 14 days post-vaccination. Our study also demonstrates that weakly positive HBsAg results often do not reflect actual HBV infection, underscoring the importance of confirmatory testing. This study also emphasizes that vaccination-induced HBsAg positives occur most commonly in hemodialysis patients.                       

StephenW

阳性B型肝炎表面抗原检查，由于最近疫苗接种
显着的健康并发症，包括肝硬化和肝癌的乙型肝炎病毒（HBV）是一种常见的病毒性肝炎的原因。 B型肝炎表面抗原（HBsAg）的测定是使用最频繁的测试，以检测HBV感染。对HBV的免疫接种可产生瞬时的患者中乙型肝炎表面抗原的检测水平。然而，目前还不清楚这种效应的时间过程和持续时间。这项回顾性研究的目的是要澄清的频率和持续时间短暂的乙肝表面抗原阳性对HBV疫苗接种后。在学术三级保健医疗中心的电子病历检索，乙肝表面抗原在17个月的时间内，找出所有的订单。详细图审查，以确定所有谁管理乙肝疫苗后的180天内乙肝表面抗原检测之前，也的弱阳性（grayzone）的结果，以确定可能的原因的患者。在17个月的研究期间，11,719乙肝表面抗原测试，下令对9930例患者。有34例乙肝疫苗乙肝表面抗原检测前14天或34进行测试。在这34例患者中，11例为乙肝表面抗原，可能是由于最近疫苗接种的grayzone结果。 10个11例患者的肾透析患者接受乙肝表面抗原检测作为常规和持续的监测。超过14天，有没有反应或grayzone的乙肝表面抗原测试，可能是由于最近的乙肝疫苗接种。乙肝表面抗原结果达到了一个高峰，COI两到三天后接种疫苗之前衰减。的所有grayzone的结果在17个月的研究期间（43 11,719测试结果出来）的进一步分析显示，只有43真正的HBV感染的结果验证测试验证。我们的研究证实，短暂的乙肝表面抗原阳性患者乙肝疫苗接种后可能会出现。结果表明，这种积极性是不可能持续超过14天接种后。我们的研究还表明，弱HBsAg阳性结果往往不能反映实际的HBV感染，强调验证测试的重要性。这项研究还强调，疫苗接种引起的乙肝表面抗原阳性血液透析患者发生的最常见的。

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把握当下

接种疫苗之后，14天以内，表面抗原最高能到多少？

StephenW

回复 把握当下 的帖子

不知道. 但不会高，只给出了灰色地带(grey zone)的结果.