[美国]在接受护理慢性病毒性肝炎的人 - 基线特征和死亡率

肝胆速递

http://cid.oxfordjournals.org/content/early/2012/09/17/cid.cis815.abstract
BASELINE CHARACTERISTICS AND MORTALITY AMONG PEOPLE IN CARE FOR CHRONIC VIRAL HEPATITIS: THE CHRONIC HEPATITIS COHORT STUDY (CHeCS)

    Anne C. Moorman1,
    Stuart C. Gordon2,
    Loralee B. Rupp2,
    Philip R. Spradling1,
    Eyasu H. Teshale1,
    Mei Lu2,
    David R. Nerenz2,
    Cynthia C. Nakasato3,
    Joseph A. Boscarino4,
    Emily M. Henkle2,
    Nancy J. Oja-Tebbe2,
    Jian Xing1,
    John W. Ward1,
    Scott D. Holmberg5, and
    for the Chronic Hepatitis Cohort Study (CHeCS) Investigators*

+ Author Affiliations

    1Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA
    2Henry Ford Health System, Detroit, MI
    3Kaiser Permanente- Hawaii
    4Geisinger Health System
    5The Center for Health Research, Kaiser Permanente Northwest, Portland OR

    Please address correspondence to: Anne C. Moorman, Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Mailstop G37, 1600 Clifton Road, N.E., Atlanta, GA 30333. PHONE: (404) 718-8567; FAX (404) 718-8585, email: [email protected]

    Alternate corresponding author: Philip R. Spradling, MD, Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Mailstop G37, 1600 Clifton Road, N.E., Atlanta, GA 30333. PHONE: (404) 718-8566; FAX (404) 718-8585, email: [email protected]

    ↵* The CHeCS Investigators are listed in the Appendix.

Abstract

Background. The Chronic Hepatitis Cohort Study (CHeCS), a dynamic prospective, longitudinal, observational cohort study, was created to assess the clinical impact of chronic viral hepatitis in the United States. This report describes the cohort selection process and baseline demographics, insurance, biopsy, hospitalization and mortality rates.

Methods. Electronic health records (EHR) of over 1.6 million adult patients seen January 2006 - December 2010 at four integrated health care systems in Detroit, MI, Danville, PA, Portland, OR, and Honolulu, HI were collected and analyzed.

Results. Of 2202 patients with chronic hepatitis B virus (HBV) infection: 50% were aged 44-63; 57% male; 58% Asian/Pacific Islanders (API), and 13% Black; and 5.1% were on Medicaid, 16.5% had Medicare, and 76.3% private insurance. During 2001-2010, 22.3% had a liver biopsy and 37.9% were hospitalized. For the 8810 patients with chronic hepatitis C virus (HCV) infection: 75% were aged 44-63 years; 60% male; 23% Black; and 12% were on Medicaid, 23% Medicare, and 62% had private insurance. During 2001-2010, 38.4% had a liver biopsy and 44.3% were hospitalized. Among persons in care, 9.0% of persons with HBV and 14.0% of persons with HCV infection, mainly those born 1945-1964, died during the 2006-10 five-year period.

Conclusions. Baseline demographic, hospitalization, and mortality data from CHeCS highlight the substantial US health burden from chronic viral hepatitis, particularly among persons born 1945-1964.

肝胆速递

基线特征和死亡率的慢性病毒性肝炎CARE FOR PEOPLE IN：慢性肝炎COHORT，研究（生态学理事会）

    安C. Moorman1，
    斯图尔特C. Gordon2，
    Loralee B. Rupp2，
    菲利普R. Spradling1，
    Eyasu H. Teshale1
    美LU2，
    大卫R. Nerenz2，
    辛西娅三Nakasato3，
    约瑟夫A. Boscarino4，
    艾米莉·Henkle2，
    南希J.欧雅-Tebbe2，
    建Xing1，
    约翰W. Ward1，
    的斯科特D. Holmberg5，，和
    慢性肝炎队列研究（生态学理事会）的研究人员*

+作者背景

    1区的病毒性肝炎国家中心HIV，肝炎，性病和结核病预防，疾病控制和预防中心，美国佐治亚州亚特兰大
    2Henry福特卫生系统，底特律，MI
    3Kaiser Permanente的夏威夷
    4Geisinger卫生系统
    5The，Kaiser Permanente的健康研究中心的西北地区俄勒冈州波特兰

    通讯作者地址：安妮C.穆尔曼，甲型病毒性肝炎部，国家中心的艾滋病毒，肝炎，性病和结核病预防，疾病控制和预防中心，Mailstop G37，1600克利夫顿路，NE，亚特兰大，GA 30333。电话：（404）718-8567，传真：（404）718-8585，电子邮件：[email protected]

    备用通讯作者：菲利普R. Spradling，MD，甲型病毒性肝炎部，国家中心的艾滋病毒，肝炎，性病和结核病预防，疾病控制和预防中心，Mailstop G37，1600克利夫顿路，NE，亚特兰大，GA 30333。电话：（404）718-8566，传真：（404）718-8585，电子邮件：[email protected]

    ↵*的生态学理事会调查人员在附录中列出。

抽象

背景。在美国，慢性肝炎队列研究（生态学理事会），一个充满活力的前瞻性，纵向，观察性队列研究，以评估慢性病毒性肝炎的临床影响。本报告描述的队列选择和基线人口统计学，保险，活检，住院率和死亡率。

方法。电子健康记录（EHR）超过160万成年患者出现2006年1月 -  2010年12月在底特律，MI，丹维尔，宾夕法尼亚州，波特兰，OR，和檀香山的四位一体的卫生保健系统，HI收集和分析。

结果。 2202例慢性乙型肝炎病毒（HBV）感染：50％年龄44-63; 57％为男性，58％的亚洲/太平洋岛民（API），和13％的黑人和医疗5.1％，16.5％医疗保险，76.3％，私人保险。在2001-2010年期间，22.3％的人肝活检，37.9％的人住院治疗。 8810例慢性丙型肝炎病毒（HCV）感染：75％的人年龄44-63岁，60％为男性，23％为黑人和12％的医疗补助，23％的医疗保险，62％有私人保险。在2001年至2010年期间，38.4％有肝活检和44.3％，住院治疗。在护理中，9.0％的人与HBV和丙型肝炎病毒感染者的14.0％，主要是那些生于1945年至1964年，在2006-2010五年期间死亡。

结论。基线人口统计学，住院和死亡的数据从生态学理事会强调美国庞大的医疗负担慢性病毒性肝炎，尤其是在出生的人，1945年至1964年。

咬牙硬挺

寿命不算长啊平均五十来岁

StephenW

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50% were aged 44-63 (50％的人年龄44-63)
9.0% of persons with HBV and 14.0% of persons with HCV infection, mainly those born 1945-1964, died during the 2006-10 five-year period.(9.0％的人,主要是那些生于1945年至1964年，在2006-2010五年期间死亡。)